2020
DOI: 10.3389/fimmu.2020.595835
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C-Reactive Protein and Cancer—Diagnostic and Therapeutic Insights

Abstract: Cancer disease describes any pathology involving uncontrolled cell growth. As cells duplicate, they can remain localized in defined tissues, forming tumor masses and altering their microenvironmental niche, or they can disseminate throughout the body in a metastatic process affecting multiple tissues and organs. As tumors grow and metastasize, they affect normal tissue integrity and homeostasis which signals the body to trigger the acute phase inflammatory response. C-reactive protein (CRP) is a predominant pr… Show more

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Cited by 158 publications
(122 citation statements)
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References 179 publications
(96 reference statements)
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“…Similar to deregulated and persistent inflammation, that is, normophysiological inflammatory processes without successful resolution, this increased immune involvement may, on the other hand, confer progressive and potentially fulminant disease [ 95 ]. Thus, the balance between an anti- or pro-inflammatory immune milieu may determine the outcome of disease progression [ 96 ], and this apparent dichotomy in the role of the immune system in tumorigenesis remains an intensive focus of research.…”
Section: Discussionmentioning
confidence: 99%
“…Similar to deregulated and persistent inflammation, that is, normophysiological inflammatory processes without successful resolution, this increased immune involvement may, on the other hand, confer progressive and potentially fulminant disease [ 95 ]. Thus, the balance between an anti- or pro-inflammatory immune milieu may determine the outcome of disease progression [ 96 ], and this apparent dichotomy in the role of the immune system in tumorigenesis remains an intensive focus of research.…”
Section: Discussionmentioning
confidence: 99%
“…As recently summarized by Hart et al (6), cancer patients are known to have elevated levels of blood CRP. Furthermore, patients with malignant disease have much higher levels of CRP than patients with benign disease, and the higher the CRP level (e.g., > 50-100 µg/ml), the worse the prognosis.…”
Section: Differentially Interpreting the Effects Of Pcrp And Mcrp In Models Of Cancermentioning
confidence: 98%
“…As with any medical condition involving a host defense response to tissue damaging pathologies, blood levels of CRP are used to monitor the presence and extent of inflammation in cancer patients ( 6 ). Most generally, blood values reflect on the pCRP isoform, which is serum soluble and easily measured using nephelometric and turbidimetric assays.…”
Section: Diagnostic Relevance Of Crp Measurement In Cancermentioning
confidence: 99%
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