C‐reactive protein and coronary composition in patients with percutaneous revascularization

Pucci, Angela; Brscic, Elvis; Tessitore, Elena; Celeste, Angela; Crudelini, M.; Bernardi, Alberto De; Alberti, Alessandro; Biondi‐Zoccai, Giuseppe; Sheiban, Imad

doi:10.1111/j.1365-2362.2008.01944.x

Cited by 9 publications

(4 citation statements)

References 39 publications

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“…hs-CRP levels have previously been shown to be associated with atherothrombotic coronary plaques [43]. In addition, results from clinical trials have suggested serum hs-CRP as being a reliable parameter to monitor the efficacy of statin therapy in patients suffering from ST-elevation myocardial infarction [44].…”

Section: Discussionmentioning

confidence: 99%

Intraplaque Expression of C-Reactive Protein Predicts Cardiovascular Events in Patients with Severe Atherosclerotic Carotid Artery Stenosis

Bonaventura

Mach

Roth

et al. 2016

Mediators of Inflammation

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Serum c-reactive protein (CRP) was suggested for the assessment of intermediate cardiovascular (CV) risk. Here, systemic or intraplaque CRP levels were investigated as predictors of major adverse cardiovascular events (MACEs) in patients with severe carotid stenosis. CRP levels were assessed in the serum and within different portions (upstream and downstream) of carotid plaques of 217 patients undergoing endarterectomy. The association between CRP and intraplaque lipids, collagen, neutrophils, smooth muscle cells (SMC), and macrophage subsets was determined. No correlation between serum CRP and intraplaque biomarkers was observed. In upstream portions, CRP content was directly correlated with intraplaque neutrophils, total macrophages, and M1 macrophages and inversely correlated with SMC content. In downstream portions, intraplaque CRP correlated with M1 and M2 macrophages. According to the cut-off point (CRP > 2.9%) identified by ROC analysis in upstream portions, Kaplan-Meier analysis showed that patients with high CRP levels had a greater rate of MACEs. This risk of MACEs increased independently of age, male gender, serum CRP, and statin use. In conclusion, in patients with severe carotid artery stenosis, high CRP levels within upstream portions of carotid plaques directly and positively correlate with intraplaque inflammatory cells and predict MACEs at an 18-month follow-up period.

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Section: Discussionmentioning

confidence: 99%

Intraplaque Expression of C-Reactive Protein Predicts Cardiovascular Events in Patients with Severe Atherosclerotic Carotid Artery Stenosis

Bonaventura

Mach

Roth

et al. 2016

Mediators of Inflammation

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“…Inflammation plays a key role in the development of atherosclerosis [15,16]. The complement system was reported to be significantly associated with vascular disease and inflammatory processes.…”

Section: Discussionmentioning

confidence: 99%

Polymorphism of the complement 5 gene and cardiovascular outcome in patients with atherosclerosis

Hoke¹,

Speidl²,

Schillinger³

et al. 2012

Eur J Clin Investigation

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“…C-reactive protein is secreted from liver and coronary plaques accompanied by stent implantation. 5,14 A plaque which contains a large necrotic core component has been pathologically reported to include a greater amount of CRP 3,15 The plaque CRP level has been reported to be correlated with a systemic CRP level. 16 A study indicated that systemic and local CRP levels after coronary stent implantation were higher in unstable angina than in stable angina.…”

Section: Discussionmentioning

confidence: 99%

“…1 High-sensitivity C-reactive protein (hsCRP) is a biomarker for low-grade inflammation and has been implicated in several aspects of coronary atherogenesis and plaque vulnerability. [2][3][4][5][6][7] Medial injury and necrotic core penetration by stenting has been reported to elevate hsCRP after stent implantation, the so-called mechanical plaque rupture, in a small number of participants. 2,5 Coronary plaque which is penetrated by stenting varies from lipid-rich to fibrous-rich.…”

mentioning

confidence: 99%

Differential Characteristics of Inflammatory Responses to Stent Implantation Between De Novo and Intrastent Restenosis Lesion in Patients With Stable Angina

et al. 2011

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Mechanical plaque rupture of coronary atherosclerotic plaque during stent implantation can increase serum levels of high-sensitivity C-reactive protein (hsCRP). Patients with stable angina pectoris were divided into 2 groups: one group included 186 patients with de novo lesion who underwent stent implantation (de novo group); the other group included 40 patients with intrastent restenosis (ISR) undergoing stent implantation (ISR group). The de novo group had a significant increase in hsCRP levels post stenting, while the ISR group showed no increase in hsCRP post stenting. Intravascular ultrasound with radiofrequency data analysis showed that the de novo group had larger percentage of both necrotic core area and fibrofatty area at the target lesion than the ISR group, while the ISR group had a larger percentage of fibrous area. Differential inflammatory response to stent implantation between the de novo plaque and in ISR lesion is related to lesion morphology.

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C‐reactive protein and coronary composition in patients with percutaneous revascularization

Abstract: We observed a positive correlation between increased serum CRP levels and typical pathological features of complex atherothrombotic coronary disease, confirming in vivo the mechanistic role of CRP in coronary atherothrombosis.

Cited by 9 publications

References 39 publications

Intraplaque Expression of C-Reactive Protein Predicts Cardiovascular Events in Patients with Severe Atherosclerotic Carotid Artery Stenosis

Intraplaque Expression of C-Reactive Protein Predicts Cardiovascular Events in Patients with Severe Atherosclerotic Carotid Artery Stenosis

Polymorphism of the complement 5 gene and cardiovascular outcome in patients with atherosclerosis

Differential Characteristics of Inflammatory Responses to Stent Implantation Between De Novo and Intrastent Restenosis Lesion in Patients With Stable Angina

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