C-reactive protein and disease outcome in Nigerian sickle cell disease patients

Okocha, CE; Manafa, PO; Jo, Ozomba; To, Ulasi; Chukwuma, George O; Aneke, JC

doi:10.4103/2141-9248.141523

Cited by 27 publications

(34 citation statements)

References 19 publications

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“…Our results call attention to indirectly protective role of us-CRP in sickle cell trait leading to increase level in serum. Regardless of age, our results were in line with the report of Krishnan et al 16 whose report included children with chest pain; further, these results were coincided with the results of Okocha et al 17 despite they conducted only Hb SS.…”

Section: Discussionsupporting

confidence: 83%

Evaluation of cardiac function tests in Sudanese adult patients with sickle cell trait

Abdelsalam

2016

Med J Indones

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Background: Cardiac dysfunctions have been recognized as a common complication of sickle cell anaemia (SCA), and together with pulmonary disorder accounts for many deaths in these patients. However, sickle cell traits appear clinically normal, although they have genetic abnormality. The aim of this study was to assess the effect of sickle cell trait on cardiac prognostic markers by measuring high density lipoprotein (HDL-C), low density lipoprotein (LDL-C), cardiac creatine kinase (CK-MB), ultra-sensitive C reactive protein (us-CRP), total homocysteine (Hyc), and N-terminal pro-brain natriuretic peptide (NT-pro BNP) tests in adult Sudanese patients with sickle cell trait.Methods: A cross-sectional study was performed in 200 healthy volunteers as a control group and 200 diagnosed patients with sickle cell trait. It was carried out in Khartoum Specialized Hospital, Al-Bayan Hospital, Obayed Clinical Center and Dr. Nadir Specialized Hospital, Sudan between January 2015 and January 2016. All participants were between 20-32 years old. LDL-C, HDL-C, CK-MB, NT-proBNP and hs-CRP concentrations were measured by Hitachi 912 full-automated Chemistry Analyzer (Roche Diagnostics, Germany) as manufacturer procedure, while homocysteine level was measured by ELISA technique using special kit.Results: When compared to control group, the levels of LDL-C, hs-CRP and NT-proBNP revealed significant increase in patients’ sera (p<0.001), while Hyc and CK-MB levels were increased insignificantly in patients with SCT (p=0.069, p=0.054 respectively). On the other hand, comparison to control group, HDL-C showed insignificant reduction in patients (p=0.099).Conclusion: The results suggest that sickle cell trait increased the risk of patient-related complication secondary to cardiac dysfunction.

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Section: Discussionsupporting

confidence: 83%

Evaluation of cardiac function tests in Sudanese adult patients with sickle cell trait

Abdelsalam

2016

Med J Indones

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“…This finding is consistent with other previous studies which linked white cell and platelet counts with disease severity in sickle cell disease [40,41]. Current patho-physiologic mechanism of vaso-occlusion in sickle cell disease has been found to involve the white cells and platelets as well as the expression of their intercellular adhesion molecules [42,43]. A high platelet count was observed to positively correlate with a tendency to develop avascular necrosis (AVN).…”

Section: Discussionsupporting

confidence: 82%

Correlation between Body Mass Index and Hematological Indices in Young Adult Nigerians with Different Hemoglobin Genotypes

Ajayi¹,

Akinbo²,

Okafor³

2017

Am. J. Biomed. Sci.

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In view of the association of various haemoglobin electrophoretic patterns with different pathological conditions and obesity with its attendant risk factors for cardiac and pulmonary disorders, the present study evaluated the relationship between body mass index and haematological indices by randomly selecting young adult Nigerians with different haemoglobin electrophoretic patterns within the age group of 17-45 years and mean age of ±31 years old. 215 participants were enlisted for this study with their BMI and other anthropometric indices measured and grouped into different BMI categories as recommended by the World Health Organization. Haematological indices such as packed cell volume, total and differential white blood cell count, and platelets as well as haemoglobin (Hb) electrophoresis were assessed in relation to their anthropometric measurements using standard methods. We observed a significantly increased neutrophil and platelet counts in the subjects with BMI > 25 kg/m 2 . BMI was also observed to be positively correlated with the neutrophil, monocyte counts and MCV of haemoglobin AS and SS genotype groups in this study. This study showed a higher percentage of overweight and obesity among females, and haematological dyscrasias in mostly the HbSS subjects. Knowledge of the relationship between BMI and hematological indices of apparently healthy individuals within any population is therefore essential in healthcare planning, as a justification for early prognosis and genetic counselling policy strategically reducing the incidence of obesity, its attendant conditions and haemoglobinopathies in Nigeria.

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“…Thirty were homozygous SCD (HbSS) patients in steady state. Steady state was defined as subjects who had been free from blood transfusion, crisis and fever for at least 3 months, one month and two weeks respectively [4].…”

Section: Methodsmentioning

confidence: 99%

“…Disease severity was determined by calculating an objective score based on scoring five parameters, pain crisis, anaemia, white cell count, SCD complications and blood transfusion. Scores of ≤3, 3-7 and ≥7 were considered mild, moderate and severe disease respectively, as described by Okocha et al [4]. Pain crisis was defined as pain that necessitated the administration of an oral or parenteral analgesic with or without visit to a chemist shop or medical facility.…”

Section: Disease Severity In Hb Ss Patientsmentioning

confidence: 99%

“…Though SCD patients have exactly the same genetic mutation, they present with a wide range of phenotypes; the reason why this happens is not completely understood. Finding biomarkers that predict these phenotypes has become very important for individualized therapy [4,5,6] some of these biomarkers may also become useful as therapeutic tools.…”

Section: Introductionmentioning

confidence: 99%

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GDF -15 and Severity Scores in Sickle Cell Disease Patients Attending Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria

Okocha¹,

Manafa²,

Anowi³

et al. 2020

JAMMR

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Aim: Granulocyte differentiation factor 15 (GDF15) is a growth factor and biomarker for many disorders where Ischaemia Reperfusion Injury (IRI) is pathophysiologically relevant. Hence the need to evaluate GDF-15 as a biomarker in Sickle Cell Disease (SCD). Study Design: This is a cross sectional study. Place and Duration of Study: Department of Haematology, Nnamdi University Teaching Hospital, Nnewi, Anambra state, Nigeria, between January and December 2018. Methods: Ninety subjects were randomly recruited with haemoglobin (Hb) phenotypes SS (test), AS and AA (controls); numbering 30, 28 and 32 respectively. Disease severity was determined by calculating an objective score. 5 mls of blood was collected and used to determine Full Blood Count (FBC), haemoglobin Phenotype and GDF-15 levels (by Enzyme Linked Immunosorbent assay). Data collected was analysed using Statistical Package for Social Sciences software version 20 (SPSS Inc., IL, Chicago, USA). P< 0.05 was considered as significant. Results: GDF-15 level was found to be significantly different in the different HB phenotypes p= 0.005 and correlated negatively with sickle cell disease severity (r= -0.307, p= 0.098). The difference between median GDF-15 levels of HBSS subjects with mild and moderate disease was statistically significant at p= 0.01. Conclusion: We hypothesize that GDF-15 may be a potential therapeutic target for intervention against ischaemia/reperfusion induced micro- vascular injury. Natural GDF-15 mimetics may be useful in taking advantage of this potential therapeutic target.

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C-reactive protein and disease outcome in Nigerian sickle cell disease patients

Cited by 27 publications

References 19 publications

Evaluation of cardiac function tests in Sudanese adult patients with sickle cell trait

Evaluation of cardiac function tests in Sudanese adult patients with sickle cell trait

Correlation between Body Mass Index and Hematological Indices in Young Adult Nigerians with Different Hemoglobin Genotypes

GDF -15 and Severity Scores in Sickle Cell Disease Patients Attending Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria

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