C-reactive protein and implications in rheumatoid arthritis and associated comorbidities

Pope, Janet; Choy, Ernest

doi:10.1016/j.semarthrit.2020.11.005

Cited by 169 publications

(123 citation statements)

References 196 publications

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“… 1 Thus, chronic inflammation in synovial joint leads to systemic complication and destruction of joints. 2 The disease activity score in RA patients can be measured using both C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). 3 The binding of CRP to Fc portion of immunoglobulin activates the synthesis of pro-inflammatory cytokines, which contribute to the pathogenesis of chronic inflammation.…”

Section: Introductionmentioning

confidence: 99%

“… 3 The binding of CRP to Fc portion of immunoglobulin activates the synthesis of pro-inflammatory cytokines, which contribute to the pathogenesis of chronic inflammation. 2 The disease activity score (DAS) has been associated with multi-biochemical marker, including CRP level. 4 Disease activity score-28 (DAS-28) utilizes both CRP and ESR to measure disease activity in RA patients.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of C-Reactive Protein and Associated Factors Among Patients Suffering from Rheumatoid Arthritis at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia

Dessie

Tadesse

Demelash

et al. 2021

OARRR

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of C-Reactive Protein and Associated Factors Among Patients Suffering from Rheumatoid Arthritis at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia

Dessie

Tadesse

Demelash

et al. 2021

OARRR

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“…Our findings are consistent with previous studies showing that elevated CD24 levels are associated with inflammation and autoimmune diseases such as inflammatory bowel disease, rheumatoid arthritis, and multiple sclerosis [ 33 , 34 , 35 , 36 ]. These chronic inflammatory diseases are also characterized by, among other clinical measures, high CRP levels [ 37 , 38 , 39 , 40 , 41 , 42 ]. Multiple lines of evidence have found correlations between autoimmune and inflammatory diseases and elevated risk of cancer: IBD was associated with an increased risk of developing colon cancer [ 43 , 44 ], and rheumatoid arthritis was associated with an elevated risk of developing lymphoma [ 45 , 46 ].…”

Section: Discussionmentioning

confidence: 99%

Predictors of the CD24/CD11b Biomarker among Healthy Subjects

Shapira

Aiger

Ohayon

et al. 2021

JPM

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The CD24 gene has raised considerable interest in tumor biology as a new prognostic factor and a biomarker for the early detection of cancer. There are currently no studies that assess predictors of CD24 in blood tests among healthy individuals. Our aims were (1) to evaluate predictors of the CD24/CD11b biomarker among healthy subjects and (2) to assess CD24/CD11b levels of participants with and without benign tumors. Our cohort included 1640 healthy subjects, aged 20–85, recruited at the Health Promotion and Integrated Cancer Prevention Center (ICPC) in the Tel Aviv Medical Center. Eligible subjects completed a detailed questionnaire on medical history and other epidemiologic information. CD24/CD11b expression in peripheral blood leukocytes (PBLs) obtained from blood samples of participants was analyzed by flow cytometry. Our results showed that the average levels of CD24/CD11b in healthy patients (22.8 ± 9.3) was statistically significant lower compared to subjects with benign cancers (26.1 ± 10.5, p < 0.001). Our multivariable analysis demonstrated that elevated levels of CRP (coefficient β: 1.98, p = 0.011) were significantly associated with high levels of CD24/CD11b expression among healthy participants. Other risk factors of cancer were not associated with elevated CD24 levels among healthy subjects. In conclusion, our findings may assist in further development and optimization of the CD24/CD11b biomarker to serve as a cancer screening test for early detection of cancer among the healthy population.

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“…In addition, also in some viral infections CRP and PCT can be increased, as observed in enteroviral or respiratory syncytial virus infections, as well as in severe SARS-CoV-2 infections with concomitant inflammation (39)(40)(41)(42). Irrespective of age, both CRP and PCT concentrations rise in response to both bacterial infection and non-infectious inflammation (43)(44)(45). Although potentially useful for disease-monitoring purposes (46)(47)(48), these two biomarkers may be sensitive but not specific to correctly discriminate early on between the type of infection or inflammation in a febrile patient.…”

Section: Crp and Pct As Current Biomarkers In The Clinicmentioning

confidence: 99%

Future Biomarkers for Infection and Inflammation in Febrile Children

2021

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Febrile patients, suffering from an infection, inflammatory disease or autoimmunity may present with similar or overlapping clinical symptoms, which makes early diagnosis difficult. Therefore, biomarkers are needed to help physicians form a correct diagnosis and initiate the right treatment to improve patient outcomes following first presentation or admittance to hospital. Here, we review the landscape of novel biomarkers and approaches of biomarker discovery. We first discuss the use of current plasma parameters and whole blood biomarkers, including results obtained by RNA profiling and mass spectrometry, to discriminate between bacterial and viral infections. Next we expand upon the use of biomarkers to distinguish between infectious and non-infectious disease. Finally, we discuss the strengths as well as the potential pitfalls of current developments. We conclude that the use of combination tests, using either protein markers or transcriptomic analysis, have advanced considerably and should be further explored to improve current diagnostics regarding febrile infections and inflammation. If proven effective when combined, these biomarker signatures will greatly accelerate early and tailored treatment decisions.

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C-reactive protein and implications in rheumatoid arthritis and associated comorbidities

Cited by 169 publications

References 196 publications

Evaluation of C-Reactive Protein and Associated Factors Among Patients Suffering from Rheumatoid Arthritis at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia

Evaluation of C-Reactive Protein and Associated Factors Among Patients Suffering from Rheumatoid Arthritis at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia

Predictors of the CD24/CD11b Biomarker among Healthy Subjects

Future Biomarkers for Infection and Inflammation in Febrile Children

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