C-Reactive Protein and Its Role in Preeclampsia

Mohaupt, Markus

doi:10.1161/hypertensionaha.114.04531

Cited by 13 publications

(12 citation statements)

References 5 publications

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“…In literature review, there were many studies regarding the role of CRP in PE and its association with disease severity, but there were few studies for PCT. [ 7 8 9 10 11 14 15 16 ]…”

Section: Discussionmentioning

confidence: 99%

“…[ 19 ] Similarly many studies have confirmed the association. [ 7 8 9 10 11 20 ] There were also studies which did not support the association. [ 21 22 23 ]…”

Section: Discussionmentioning

confidence: 99%

“…The reminder studies have indicated that CRP was higher in severe PE and mild PE, and it has a predicative value for determination of severity of the disease. [ 7 8 9 10 11 ]…”

Section: Discussionmentioning

confidence: 99%

“…Though most of the studies demonstrated high level of CRP in pregnant women with PE, the predictive role of CRP for occurrence of PE is controversial. [ 7 8 9 10 11 ]…”

Section: Introductionmentioning

confidence: 99%

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Level of High Sensitive C-reactive Protein and Procalcitonin in Pregnant Women with Mild and Severe Preeclampsia

Jannesari

Kazemi

2017

Adv Biomed Res

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Background:In this study, we compare the level of two inflammatory markers, high sensitive C-reactive protein (hs-CRP) and procalcitonin (PCT), in pregnant women with mild and severe preeclampsia (PE) and women with normal pregnancy.Materials and Methods:In this case–control study, normal pregnant women and pregnant women with PE were enrolled. Pregnant women with diagnosed PE were selected as case group and classified into two groups with mild and severe PE. Serum samples for measurement of hs-CRP and PCT were obtained and compared in studied groups.Results:In this study, 50 normal pregnant women and 59 pregnant women with PE, 26 (44.1%) mild, and 33 (55.9%) severe were studied. Mean of hs-CRP and PCT was higher in pregnant women with PE than normal pregnant women (7.71 ± 6.19 vs. 5.44 ± 3.94, P = 0.02 for hs-CRP and 0.05 ± 0.03 vs. 0.04 ± 0.01, P = 0.001 for PCT). Area under curve for hs-CRP and PCT was 0.611 and 0.646, respectively. The optimal cut-off point for hs-CRP was 5.24 with a sensitivity of 62.7% and a specificity of 56%. The optimal cut-off point for PCT was 0.042 with a sensitivity of 71% and a specificity of 54%.Conclusion:The findings of this study indicated that higher level of hs-CRP and PCT in pregnant women with PE than those with normal pregnancy could potentially explain the exaggerated inflammation in PE. Regarding significantly increased level of hs-CRP in severe PE than mild PE, we could suggest that hs-CRP is more appropriate marker for investigating pregnant women with severe PE, and its clinical usefulness is superior to PCT in this regard.

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“…In literature review, there were many studies regarding the role of CRP in PE and its association with disease severity, but there were few studies for PCT. [ 7 8 9 10 11 14 15 16 ]…”

Section: Discussionmentioning

confidence: 99%

“…[ 19 ] Similarly many studies have confirmed the association. [ 7 8 9 10 11 20 ] There were also studies which did not support the association. [ 21 22 23 ]…”

Section: Discussionmentioning

confidence: 99%

“…The reminder studies have indicated that CRP was higher in severe PE and mild PE, and it has a predicative value for determination of severity of the disease. [ 7 8 9 10 11 ]…”

Section: Discussionmentioning

confidence: 99%

“…Though most of the studies demonstrated high level of CRP in pregnant women with PE, the predictive role of CRP for occurrence of PE is controversial. [ 7 8 9 10 11 ]…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Level of High Sensitive C-reactive Protein and Procalcitonin in Pregnant Women with Mild and Severe Preeclampsia

Jannesari

Kazemi

2017

Adv Biomed Res

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“…Inflammation is a risk factor for chronic diseases, and is also associated with several adverse reproductive outcomes. Indeed, high‐sensitivity C‐reactive protein (hsCRP), a commonly used measure of inflammation, is associated with an increased risk of recurrent pregnancy loss, recurrent in‐vitro fertilization failure, preeclampsia, gestational diabetes, preterm birth, and foetal growth restriction . Better understanding the role of low‐grade inflammation in reproduction may have significant value, given the potential for therapeutic use of widely available and effective anti‐inflammatory treatments, for example aspirin or statins, which are successfully used to prevent cardiovascular events in middle‐aged adults with higher hsCRP .…”

mentioning

confidence: 99%

Prevalence and Contributors to Low‐grade Inflammation in Three U.S. Populations of Reproductive Age Women

Sjaarda

Radin

Swanson

et al. 2017

Paediatric Perinatal Epid

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Background: Inflammation, measured by high-sensitivity C-reactive protein (hsCRP), is linked to adverse reproductive outcomes. However, prevalence and predictors of low-grade inflammation are poorly understood among reproductive age women. Therefore, the current aim was to characterize: (i) the prevalence of elevated hsCRP and (ii) whether the association of various demographic, anthropometric, life style, and metabolic characteristics with higher hsCRP varies across populations of reproductive age women with varying risk profiles for adverse reproductive outcomes. Methods: Bivariate analysis of characteristics among women ages 18-40 having hsCRP <2.0 vs. ≥2.0 mg/L in the BioCycle Study (N = 259), the Effects of Aspirin in Gestation and Reproduction Trial (EAGeR) (N = 1228), and the National Health and Nutrition Examination Survey (NHANES; N = 2173) were conducted. Multivariable regression analysis estimated the association of all characteristics to hsCRP within each cohort. Results: Prevalence of hsCRP≥2 mg/L ranged from 20 to 40%. Age, BMI, waist circumference, blood pressure, lipids, glucose, and insulin were frequently higher in women with hsCRP ≥2 mg/L. In multivariable models, however, only adiposity (BMI, waist circumference) was independently associated with hsCRP within all three cohorts. Some variables showed cohort-specific associations with higher hsCRP: white race (EAGeR), higher fasting glucose (BioCycle), and lesser education and employment (NHANES). The total characteristics explained 28-46% of the variation in hsCRP across the three cohorts. Conclusions: Low-grade inflammation was common, including among predominantly non-obese women, affecting from 20 to 40% of reproductive age women. Given the potential to reduce inflammation through inexpensive, widely available therapies, examination of the impact of chronic inflammation on reproductive and pregnancy outcomes, as well as preventive interventions, are now needed.

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Association Between Hypertensive Disorders of Pregnancy and Neurodevelopmental Outcomes Among Offspring

et al. 2021

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Key Points Question Are hypertensive disorders of pregnancy (HDP) associated with poorer neurodevelopmental outcomes in offspring independently of shared familial confounding factors? Findings In this cohort study, offspring of HDP-complicated pregnancies had a somewhat higher incidence of autism spectrum disorders (ASDs), attention-deficit/hyperactivity disorder (ADHD), and intellectual disability (ID) and slightly lower overall cognitive performance. Analyses comparing siblings had less statistical power and indicated associations of a similar magnitude with ASDs and possibly ADHD only. Meaning This study suggests that HDP are associated with modestly increased risks of ASDs and possibly ADHD in offspring, whereas associations with ID and cognitive performance are likely the result of confounding by shared familial characteristics.

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C-Reactive Protein and Its Role in Preeclampsia

Cited by 13 publications

References 5 publications

Level of High Sensitive C-reactive Protein and Procalcitonin in Pregnant Women with Mild and Severe Preeclampsia

Level of High Sensitive C-reactive Protein and Procalcitonin in Pregnant Women with Mild and Severe Preeclampsia

Prevalence and Contributors to Low‐grade Inflammation in Three U.S. Populations of Reproductive Age Women

Association Between Hypertensive Disorders of Pregnancy and Neurodevelopmental Outcomes Among Offspring

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