C-reactive protein and mortality in mild to moderate chronic obstructive pulmonary disease

Man, S. F. Paul; Connett, John E.; Anthonisen, N. R.; Wise, Robert A.; Tashkin, Donald P.; Sin, Don D.

doi:10.1136/thx.2006.059808

Cited by 342 publications

(253 citation statements)

References 33 publications

Supporting

Mentioning

229

Contrasting

Unclassified

Order By: Relevance

“…However, it is not clear at this time whether CRP is more than just a barometer of the intensity of the inflammatory process, or an actual participant in the pathogenesis of the disease. Importantly, levels of CRP in the blood correlate well with future risk of morbidity and mortality in COPD (79,80).…”

Section: Biomarkers For the Evaluation Of Diseasementioning

confidence: 99%

New Concepts in the Pathobiology of Chronic Obstructive Pulmonary Disease

Kim¹,

Rogers²,

Criner³

2008

Proceedings of the American Thoracic Society

175

120

View full text Add to dashboard Cite

Chronic obstructive pulmonary disease (COPD) is characterized by an abnormal persistent inflammatory response to cigarette smoke. This noxious insult leads to emphysema and airway remodeling, manifested by squamous and mucous metaplasia of the epithelium, smooth muscle hypertrophy, and airway wall fibrosis. These pathologic abnormalities interact synergistically to cause progressive airflow obstruction. Although it has been accepted that the spectrum of COPD is vast, the reasons for the development of different phenotypes from the same exposure to cigarette smoke have not been determined. Furthermore, it is becoming increasingly clear that airways disease and emphysema often coexist in many patients, even with a clear clinical phenotype of either emphysema or chronic bronchitis. Recent studies have focused on the nature of the inflammatory response to cigarette smoke, the inflammatory cell lines responsible for COPD pathogenesis, and new biomarkers for disease activity and progression. New cytokines are being discovered, and the complex interactions among them are being unraveled. The inflammatory biomarker that has received the most attention is Creactive protein, but new ones that have caught our attention are interleukin (IL)-6, tumor necrosis factor-a, IL-8, and IL-10. Further research should focus on how these new concepts in lung inflammation interact to cause the various aspects of COPD pathology.

show abstract

Section: Biomarkers For the Evaluation Of Diseasementioning

confidence: 99%

New Concepts in the Pathobiology of Chronic Obstructive Pulmonary Disease

Kim¹,

Rogers²,

Criner³

2008

Proceedings of the American Thoracic Society

175

120

View full text Add to dashboard Cite

show abstract

“…A leakage of inflammatory mediators into the capillaries of the lungs results in a systemic inflammatory response [9,10]. Thus, raised levels of systemic inflammatory markers, such as the C-reactive protein (CRP), are associated with increased all-cause mortality, cancer, and cardiovascular death [13]. …”

Section: Introductionmentioning

confidence: 99%

Oxidant status, iron homeostasis, and carotenoid levels of COPD patients with advanced disease and LTOT

Kentson

Leanderson

Jacobson

et al. 2018

European Clinical Respiratory Journal

View full text Add to dashboard Cite

Background: The pathogenesis of chronic obstructive pulmonary disease (COPD) is associated with oxidative stress. Both iron (Fe) and oxygen are involved in the chemical reactions that lead to increased formation of reactive oxygen species. Oxidative reactions are prevented by antioxidants such as carotenoids. Objective: To study the differences in Fe status, carotenoid levels, healthy eating habits, and markers of inflammation and oxidative damage on proteins in subjects with severe COPD ± long-term oxygen therapy (LTOT) and lung-healthy control subjects. Methods: Sixty-six Caucasians with advanced COPD (28 with LTOT) and 47 control subjects were included. Questionnaires about general health, lifestyle, and dietary habits were answered. Lung function tests and blood sampling were performed. Results: COPD subjects (±LTOT) did not demonstrate increased oxidative damage, assessed by protein carbonylation (PC), while levels of soluble transferrin receptors (sTfRs) were slightly elevated. Soluble TfRs, which is inversely related to Fe status, was negatively associated with PC. Levels of carotenoids, total and β-cryptoxanthin, α- and β-carotenes, were significantly lower in COPD subjects, and their diet contained significantly less fruits and vegetables. Lutein correlated inversely with IL-6, lycopene correlated inversely with SAT, while β-carotene was positively associated with a Mediterranean-like diet. Conclusions: Fe could favor oxidative stress in COPD patients, suggesting a cautious use of Fe prescription to these patients. COPD subjects ate a less healthy diet than control subjects did and would, therefore, benefit by dietary counseling. COPD patients with hypoxemia are probably in particular need of a lycopene-enriched diet.

show abstract

“…The circulating CRP levels are associated with an increased mortality Biochemistry Section Anup n. nillAWAr, KedAr B. JoShi, SAndip BhArAt pAtil, JAyShree S. BArdApurKAr, SuhAS J. BArdApurKAr in COPD. CRP is found to be inversely associated with the FEV1 %, which is predicted in stable COPD [4,11]. High sensitive C-Reactive Protein (HS-CRP) is considered as a marker of systemic inflammation and this is also assessed for the primary stratification of the general population for the risk of CVD [12].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of HS-CRP and Lipid Profile in COPD

Nillawar¹

2013

JCDR

View full text Add to dashboard Cite

Introduction: COPD is a major public health problem. More than 50 % of the patients of COPD die because of some cardiovascular event. Traditionally, the risk of CVD is assessed by the presence of dyslipidaemia. Recently, HS-CRP has emerged as a novel risk factor for the CVD assessment. In this study, we assessed the patients of COPD for CVD with HS-CRP and lipid indicators. Material and Methods:Forty Five diagnosed patients of COPD and 45 age, sex, and BMI matched healthy controls were enrolled for the study after the institutional ethical committee's clearance was obtained. The fasting serum samples of the study subjects were evaluated for the lipid profile and HS-CRP. Results:There was no statistical difference in the lipid profile in the two groups, while HS-CRP was significantly raised in the COPD patients. On applying kappa statistics, we found a poor agreement between the lipid parameters and HS-CRP in estimating the risk for CVD. This underlines the independent importance of HS-CRP in the CVD assessment of COPD patients. Discussion: GOLD has described COPD as a systemic chronic inflammatory disease which involves the lung and the distant organs by the emissary of the systemic inflammation, which is also an antecedent to cardiovascular diseases. COPD is a systemic inflammatory disease which is underlined by this study. But the derangement of the lipid indicators is not statistically significant. This suggests the addition of HS-CRP in the assessment of the COPD patients for CVD. This further needs to be ascertained in a large prospective model. Conclusion:COPD is systemic inflammatory disease, but there is hardly any derangement of the lipid indicators.

show abstract

C-reactive protein and mortality in mild to moderate chronic obstructive pulmonary disease

Cited by 342 publications

References 33 publications

New Concepts in the Pathobiology of Chronic Obstructive Pulmonary Disease

New Concepts in the Pathobiology of Chronic Obstructive Pulmonary Disease

Oxidant status, iron homeostasis, and carotenoid levels of COPD patients with advanced disease and LTOT

Evaluation of HS-CRP and Lipid Profile in COPD

Contact Info

Product

Resources

About