2008
DOI: 10.1258/acb.2007.007133
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C-reactive protein and procalcitonin concentrations in bronchoalveolar lavage fluid as a predictor of ventilator-associated pneumonia

Abstract: Background: Diagnosis of ventilator-associated pneumonia (VAP) is difficult. The usefulness of high-sensitivity procalcitonin (ProCa-S) and high-sensitivity C-reactive protein (CRPH) in bronchoalveolar lavage (BAL) fluid and serum in the prediction of VAP was determined. Methods: The study was conducted over a 28-month period (November 1999-June 2002 at the University Hospital Maastricht. BAL fluid samples were collected from patients admitted to the intensive care unit. Differential cell count and quantitativ… Show more

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Cited by 41 publications
(38 citation statements)
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“…A good correlation has been found between PCT in serum and BALF [40, 41]. Studies focusing on PCT in BALF samples only, however, have led to disappointing results.…”
Section: Discussionmentioning
confidence: 99%
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“…A good correlation has been found between PCT in serum and BALF [40, 41]. Studies focusing on PCT in BALF samples only, however, have led to disappointing results.…”
Section: Discussionmentioning
confidence: 99%
“…Studies focusing on PCT in BALF samples only, however, have led to disappointing results. In some cases, very low concentrations were found in the alveolar space making it impossible to use PCT in the differentiation of pulmonary disease [4044]. Low sensitivity of methods of detection and the dilution effect of BALF may have been the reasons for this [40, 43].…”
Section: Discussionmentioning
confidence: 99%
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“…In those patients with PCP the median values for BG in serum and BAL were 406 pg/mL and 500 pg/mL, respectively. When BG has been measured in BAL 17,18 the data appear to indicate that it does not add to the diagnostic accuracy of serum levels alone. Of note, both studies involved ventilator-associated pneumonia patients, not HIV patients with acute pulmonary infiltrates.…”
Section: Introductionmentioning
confidence: 94%
“…The rationale is to identify and, if necessary, to dose specific markers of alveolar infection (not of bron-chial colonization): either endogenous mediators released locally by alveolar macrophages activated by microbial products or direct products of parenchymal destruction [9]. A number of biomarkers - including soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) [10], procalcitonin (PCT) [11], copeptin [12], C-reactive protein (CRP) [13], interleukin-1-beta, granulocyte colony-stimulating factor, macrophage inflammatory protein-1-alpha [14], plasminogen activation inhibitor-1 [15], surfactant protein D, receptor of advanced glycation end-products [16], midregional proatrial natriuretic peptide [17], and endotoxin [18] or elastin [19] fibers - have been tested recently for use in determining the diagnosis and prognosis for patients with suspected or confirmed VAP. Globally, the results of studies evaluating the value of biomarkers in diagnosing VAP are contradictory.…”
mentioning
confidence: 99%