C-reactive protein and procalcitonin during febril attacks in PFAPA syndrome

Periodic Fever, Aphthosis, Pharyngitis, and Adenitis Syndrome: Analysis of Patients From Two Geographic Areas

“…There is no specific laboratory test that can confirm a diagnosis of PFAPA syndrome. PFAPA syndrome patients usually present with leukocytosis and elevated ESR and CRP levels during febrile attacks while procalcitonin levels are usually within normal limits . Our findings were consistent with those of previous studies.…”

Review of autoinflammatory diseases, with a special focus on periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome

“…Several small studies have suggested that procalcitonin, a marker associated with infection, is not markedly elevated during febrile episodes of PFAPA . These results parallel the findings in FMF, in which a slight but significant increase in procalcitonin levels was observed during inflammatory episodes .…”

Is colchicine more effective to prevent periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis episodes in Mediterranean fever gene variants?

“…Erythrocyte sedimentation rate, SAA and CRP were raised during febrile attacks, similar to previous studies. 11,[23][24][25] Procalcitonin concentration does not increase with the increase of other acute-phase reactants during attacks, which identifies this protein as a possible useful marker for differentiating PFAPA syndrome from infection. During the PFAPA episodes, 97.3% in 296 evaluated patients of the present patients had normal serum procalcitonin (data not shown).…”