C-reactive protein and procalcitonin for the early detection of anastomotic leakage after elective colorectal surgery: Pilot study in 100 patients

Abstract

Procalcitonin is neither earlier nor more accurate than CRP for the detection of anastomotic leakage after elective colorectal surgery.

The value of biomarkers in early diagnosis of anastomotic leak following colorectal tumor resection: a review of the literature between 2012 and 2017

“…Raised PCT serum concentration on postoperative days 3 to 5 renders necessary a careful evaluation of the patient before discharge [9]. Similar conclusions had been got in other researches [7,10,14,18]. There are also studies to determine whether PCT in drain fluid can serve as screening tool for AL [19].…”

“…The cut-off value of 140 mg/L on POD3 maximized the sensitivity (78%) and specificity (86%) of serum CRP in assessing the risk of leakage [6]. Serum CRP has been evaluated in other 11 studies [7][8][9][10][11][12][13][14][15][16][17]. In general, the CRP level was raised significantly days before the diagnosis of AL.…”

Sarcopenia is associated with an increased inflammatory response to surgery in colorectal cancer

“…However, an increased inflammatory response following surgery has not yet been investigated. After colorectal surgery, prolonged elevation of inflammatory markers is associated with severe complications such as anastomotic leakage and sepsis [21,22], which provides an interesting relationship between sarcopenia and development of complications. Indeed, low muscle mass is associated with postoperative infective complications after colorectal surgery as recently found by Lieffers et al [5].…”

Procalcitonin Reveals Early Dehiscence in Colorectal Surgery

“…20 There is also a review investigating the usefulness of PCT for bacterial peritonitis diagnosis in patients with decompensated liver cirrhosis or under peritoneal dialysis. 21 After analyzing the 18 studies published on the field, the authors conclude that PCT is a sensitive and specific test for diagnosis of bacterial peritonitis, with a better predictive capacity than CRP. 15 Lagoutte et al published the first study comparing PCT and CRP after colorectal surgery.…”