C-reactive protein and risk of heart failure. The Rotterdam Study

Kardys, Isabella; Knetsch, A; Bleumink, Gysèle S.; Deckers, Jaap W.; Hofman, Albert; Stricker, Bruno H. Ch.; Witteman, Jacqueline C. M.

doi:10.1016/j.ahj.2006.02.023

Cited by 99 publications

(55 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Production, regulation of the production and plasma/serum levels of CRP CRP, a part of an acute phase reaction, previously considered to be a marker of underlying infection or tissue injury, was later found also as a marker of chronic low-grade non-infectious systemic inflammation. Associations between increased levels of CRP and clinical course of the acute MI and other acute coronary syndrome were found (Berk et al, 1990;De Beer et al, 1982;Kardys et al, 2006;Pepys  Hirschfield, 2003). It was confirmed that CRP is a better risk predictor of the cardiovascular events then LDL levels (Ridker, 2003).…”

Section: Nonspecific Inflammatory Markers and Cardiovascular Diseasessupporting

confidence: 56%

“…Increased levels of IL-6 were found in patients with unstable angina, where inflammatory reaction may promote conversion of a stable atherosclerotic plaque to an unstable one (Biasucci et al, 1996). It was also found that plasma CRP level can predict future cardiovascular events or mortality due to coronary heart disease even in healthy individuals (Dvorakova & Poledne, 2004;Kardys et al, 2006;Koenig et al, 2006). CRP predicts cardiovascular risk even in Japanese, who generally have lover levels (Saito et al, 2007).…”

Section: Crp and Proinflammatory Cytokines -The Cause And The Results mentioning

confidence: 99%

See 1 more Smart Citation

Inflammation and Genetics of Inflammation in Cardiovascular Diseases

Bucová¹

2011

Angina Pectoris

View full text Add to dashboard Cite

Section: Nonspecific Inflammatory Markers and Cardiovascular Diseasessupporting

confidence: 56%

Section: Crp and Proinflammatory Cytokines -The Cause And The Results mentioning

confidence: 99%

Inflammation and Genetics of Inflammation in Cardiovascular Diseases

Bucová¹

2011

Angina Pectoris

View full text Add to dashboard Cite

“…CRP and CHF: hsCRP is generated by the liver in response to various inflammatory stimuli and is a potent risk factor for coronary artery disease including acute myocardial infarction, 18,19) and for a poor prognosis for cardiovascular diseases, [20][21][22] dilated cardiomyopathy 23) and heart failure. 1,2) In a prospective cohort study of 6437 Dutch outpatients, CRP was found to predict incident heart failure in men, even after adjustment for traditional cardiovascular risk factors and comorbid coronary heart diseases. 6) In the Valsartan Heart Failure Trial (Val-Heft), CRP was an independent predictor of mortality and morbidity in patients with established heart failure (CRP > 3.23 mg/L, HR 1.23, 95% CI: 1.05-1.44, P = 0.009).…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, circulating levels of inflammatory biomarkers increase with advancing severity of heart failure. 1,2) Among biomarkers of inflammatory status, C-reactive protein (CRP) is the most widely used predictor of worse clinical outcomes. [3][4][5][6] Cardiac resynchronization therapy (CRT) is a well established treatment for patients with severe heart failure despite optimal medical treatment.…”

mentioning

confidence: 99%

High Sensitivity C-Reactive Protein Predicts Nonresponders and Cardiac Deaths in Severe Heart Failure Patients After CRT Implantation

et al. 2012

View full text Add to dashboard Cite

SummaryThe purpose of this study was to determine whether high sensitivity C-reactive protein (hsCRP) before cardiac resynchronization therapy (CRT) implantation was able to predict the response to CRT and cardiac deaths in severe heart failure patients. The study population consisted of 65 heart failure patients (46 males, mean age 65.0 ± 11.8 years, NYHA class III/IV) with CRT implantation. Levels of hsCRP and B-type natriuretic peptide (BNP) were measured before CRT implantation. Left ventricular end-diastolic volume index (LVEDVI), left ventricular end-systolic volume index (LVESVI), and left ventricular ejection fraction (LVEF) were assessed by echocardiography at the same time. At 6 months after device implantation follow-up, echocardiography was performed and reverse remodeling was defined as > 15% reduction in LVESV. Of the 61 patients (4 patients died within 6 months), 41 patients (67%) and 20 patients (33%) were classified as responders (group-R) and nonresponders (group-NR), respectively. Cardiac deaths occurred more frequently in group-NR than in group-R (29% versus 5%, P < 0.05). Hs-CRP level was significantly higher in group-NR than in group-R (P < 0.01). Multivariate logistic regression analysis showed an independent relationship between hsCRP and the incidence of nonresponders (odds ratio: 1.499, P = 0.011). Stepwise multivariate Cox proportional hazard analysis identified the hsCRP level as the strongest predictive factor for cardiac death (hazard ratio: 1.337, P = 0.001). Receiver operating characteristic (ROC) analysis revealed hsCRP levels of 3.0 mg/L as the cut-off value for cardiac mortality. The hsCRP level may provide a new insight into CRT implantation for severe heart failure by predicting responses to CRT and cardiac death. (Int Heart J 2012; 53: 306-312)

show abstract

“…The severity of OSAS, as shown in most studies, is independently associated with elevated markers of systemic inflammation, including CRP. CRP is directly associated with an increased atrial fibrillation burden [30] and strongly and independently associated with occurrence of heart failure [31,32] . Furthermore, serum levels of CRP were significantly increased in patients with OSAS and an acute cardiovascular event [33] .…”

Section: Is Crp Part Of the Link Between Cvd And Osas?mentioning

confidence: 99%

Obstructive sleep apnea syndrome and cardiovascular disease: The influence of C-reactive protein

Bouloukaki¹,

Mermigkis²,

Kallergis³

et al. 2015

WJEM

View full text Add to dashboard Cite

Obstructive sleep apnea syndrome (OSAS) is a common medical condition, associated with atherosclerosis and cardiovascular disease (CVD). The underlying pathophysiologic mechanisms of this association have not been completely understood and may be multifactorial in origin. A number of studies suggest that inflammatory processes have emerged critical in the pathogenesis of CVD in OSAS. A range of circulating inflammatory molecules has been identified and measured, with a view to assess inflammation and predict vascular damage risk, such as plasma cytokines, adhesion molecules, and C-reactive protein (CRP). CRP is a relevant marker worthy of further study, because not only is elevated in patients with OSAS, but also is rapidly becoming a risk factor for cardiac disease. Furthermore, in selected OSAS patients, aggressive treatment of the disorder may lead to retarding or even improvement of CVD progression. However, still there is a debate on the true correlation between CRP and OSAS, as well as the clinical effect of any reduction after OSAS treatment. Further research is required to define those OSAS patients who will have a considerable reduction with treatment, as well as to understand the significance of the interaction between cardiovascular risk factor and CRP reduction in patients with OSAS.

show abstract

C-reactive protein and risk of heart failure. The Rotterdam Study

Cited by 99 publications

References 18 publications

Inflammation and Genetics of Inflammation in Cardiovascular Diseases

Inflammation and Genetics of Inflammation in Cardiovascular Diseases

High Sensitivity C-Reactive Protein Predicts Nonresponders and Cardiac Deaths in Severe Heart Failure Patients After CRT Implantation

Obstructive sleep apnea syndrome and cardiovascular disease: The influence of C-reactive protein

Contact Info

Product

Resources

About