C-Reactive Protein and the 10-Year Incidence of Coronary Heart Disease in Older Men and Women

Cushman, Mary; Arnold, Anita; Psaty, BM

doi:10.1016/j.accreview.2005.10.017

Cited by 66 publications

(83 citation statements)

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“…Subgroup analysis was defined according to FRS categories (15 studies † †), categories of other factors (16 studies ‡ ‡), or a combination (7 studies 16,40,45,48,54,62,69 ). Improved prediction in one subgroup vs others was claimed in 25 Overall, 63 articles ¶ ¶ (80%) claimed improved prediction for at least 1 predictor and 1 outcome.…”

Section: Subgroup Analysesmentioning

confidence: 99%

Assessment of Claims of Improved Prediction Beyond the Framingham Risk Score

Tzoulaki

Liberopoulos

Ioannidis

2009

JAMA

248

201

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Section: Subgroup Analysesmentioning

confidence: 99%

Assessment of Claims of Improved Prediction Beyond the Framingham Risk Score

Tzoulaki

Liberopoulos

Ioannidis

2009

JAMA

248

201

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“…Higher levels of interleukin (IL)-6 (Pickup et al 2000;Pradhan et al 2001), leptin (HaVner et al 1999, plasminogen activator inhibitor (PAI)-1 (Festa et al 2002;Kanaya et al 2006a), tumor necrosis factor (TNF)- (Pickup et al 2000;Winkler et al 1998), C-reactive protein (CRP) (Pradhan et al 2001;Yuan et al 2006) and lower levels of adiponectin (Weyer et al 2001) are associated with increasing insulin resistance and type 2 diabetes. Higher levels of CRP (Cesari et al 2003;Cushman et al 2005;Tuomisto et al 2006), TNF- (Cesari et al 2003;Tuomisto et al 2006), PAI-1 (Kohler and Grant 2000;Agirbalsi 2005), and IL-6 (Cesari et al 2003;Tuomisto et al 2006), and lower adiponectin (Pischon et al 2004) are associated with increased risk of cardiovascular events.…”

Section: Introductionmentioning

confidence: 97%

Genetic admixture, adipocytokines, and adiposity in Black Americans: the Health, Aging, and Body Composition study

et al. 2007

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Adipocytokines are a subset of cytokines produced by adipose tissue and are associated with risk of type II diabetes and atherosclerosis. Levels of adipocytokines differ between Black and White Americans, even after adjustment for differences in adiposity, diseases associated with adipocytokines including type 2 diabetes and cardiovascular disease, and general socioeconomic status indicators such as income. We used a series of ancestry informative markers to estimate genetic ancestry in a population-based study of older Black Americans, and examined the association between genetic ancestry and adipocytokines and soluble receptors to help determine which of these may be most amenable to admixture mapping. We typed 35 ancestry informative markers in 1,241 self-reported Black Americans with available DNA from the Health, Aging, and Body Composition (Health ABC) study with available DNA and used a maximum likelihood approach to estimate percent European ancestry. We used linear regression models to determine the association between these adipocytokines and percent ancestry, and staged models to examine whether adiposity or other measures affected the associations of genetic ancestry and adipocytokines. Mean European ancestry was 22.3+/-15.9%. In multivariate adjusted models, the strongest associations observed were between higher European ancestry and interleukin-6 soluble receptor (IL-6 SR), C-reactive protein (CRP), and adiponectin levels, with interleukin-2 soluble receptor (IL-2 SR) and soluble tumor necrosis factor receptor II (TNF-alpha SR II) also showing more modest but significant associations. The association with adiponectin became stronger after adjustment for adiposity. These novel findings suggest that admixture mapping may identify genetic factors influencing the levels of IL-6 SR, CRP, IL-2 SR, and adiponectin.

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“…Van Exel et al [16] found that elderly men with a history of stroke had elevated levels of C-reactive protein (CRP). In a recent prospective study of elderly men and women over age 65, Cushman et al [17] found that a single CRP measurement improved the Framingham Risk Score. The measured level of CRP was positively associated with 10-year risk of CHD.…”

Section: Introductionmentioning

confidence: 97%

Association between tobacco smoke exposure and levels of C-reactive protein in the Oslo II Study

et al. 2007

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It is well known that tobacco smoke exposure is related to the risk of developing cardiovascular diseases and events. One mechanism could be that tobacco smoke acts on the cardiovascular system by altering the autonomic function and/or inducing inflammatory responses. We used data from 3 744 men aged 67-77 years from the city of Oslo that participated in the health screening for the Oslo II Health Study in 2000, to explore associations between C-reactive protein and environmental exposures including exposure to tobacco smoke products. Levels of C-reactive protein were higher in current smokers (2.05 mg/l, IQR, 1.11-4.17 mg/l), compared to former-smokers (1.58 mg/l, IQR, 0.83-3.03 mg/l) and non-smokers (1.26 mg/l, IQR, 0.65-2.40 mg/l). The risk of elevated C-reactive protein increased with both numbers of current cigarettes smoked per day and numbers of pack-years of smoking, when other factors were adjusted for (P < 0.001). We found a positive dose-response relationship between amount of current cigarette smoking and elevated C-reactive protein levels. These findings support the idea that the induction or exacerbation of inflammation could be a mechanism by which smoking promotes atherosclerotic cardiovascular diseases.

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C-Reactive Protein and the 10-Year Incidence of Coronary Heart Disease in Older Men and Women

Cited by 66 publications

References 0 publications

Assessment of Claims of Improved Prediction Beyond the Framingham Risk Score

Assessment of Claims of Improved Prediction Beyond the Framingham Risk Score

Genetic admixture, adipocytokines, and adiposity in Black Americans: the Health, Aging, and Body Composition study

Association between tobacco smoke exposure and levels of C-reactive protein in the Oslo II Study

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