C-reactive protein as a biomarker of response to inhaled corticosteroids among patients with COPD

Oshagbemi, Olorunfemi A.; Franssen, Frits M.E.; Wouters, Emiel F.M.; Zee, Anke‐Hilse Maitland‐van der; Driessen, Johanna H M; Boer, Anthonius de; Vries, Frank de

doi:10.1016/j.pupt.2019.101870

Cited by 1 publication

(1 citation statement)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In patients with acute exacerbations, CRP levels tend to increase, a conclusion reached after testing about 36 biomarkers, with good diagnostic accuracy, increased levels correlating with raised white blood cell count, and a purulent expectorate because of bacterial infection [ 6 ]. Studies have proposed that serial measurements of plasma CRP can lead to favorable outcomes of COPD when treated with inhaled corticosteroids and antibiotics [ 7 , 8 ]. Furthermore, CRP is also thought to be a contributing factor in determining the prognosis of COPD, as such increased levels are not only seen in acute exacerbations but also chronic, stable disease, indicating an ongoing low-level, underlying inflammatory activity, even when compared to smokers without the disease [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

C-reactive Protein as a Predictor of Severity in Chronic Obstructive Pulmonary Disease: An Experience From a Tertiary Care Hospital

Hassan¹,

Jabbar²

2022

Cureus

View full text Add to dashboard Cite

Background In this study, we aimed to determine the frequency of raised C-reactive protein (CRP) levels and their association with the severity of the disease. Methodology This descriptive cross-sectional study was conducted at the Shifa International Hospital, Islamabad, from June 2018 to December 2018 in the Department of Medicine. Patients attending the respiratory outpatient clinic in the Department of Medicine, Shifa International Hospital, Islamabad, with chronic obstructive pulmonary disease, meeting the sample selection criteria, were included in our study. A total of 104 patients were enrolled. All patients had plasma CRP levels measured, and forced expiratory volume in one second to forced vital capacity ratio was calculated to quantify the severity of the disease. We used SPSS version 26.0 (IBM Corp., Armonk, NY, USA) for data analysis. Results All patients with levels of hs-CRP greater than 3 mg/L had stage 3 or 4 chronic obstructive pulmonary disease (COPD) according to Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria, which accounted for 16.4% of the sample, while 81.7% of all patients suffering from COPD had levels greater than 1 mg/L. Only a small minority of patients, 1.9%, had normal high-sensitivity (hs)-CRP levels. The relationship between high levels of hs-CRP levels and advanced stages of COPD was statistically significant (p < 0.001). Conclusions The severity of COPD is directly related to the raised CRP levels, which can help in identifying these patients and managing them subsequently. It can be a useful indicator and a basis for high suspicion index and close follow-up for patients with high levels.

show abstract

Section: Introductionmentioning

confidence: 99%