C-Reactive Protein, Chemerin, Fetuin-A and Osteopontin as Predictors of Cardiovascular Risks in Persons With Psoriasis Vulgaris

Borský, Pavel; Fiala, Zdeněk; Andrýs, Ctirad; Beránek, M.; Hamáková, Květoslava; Kremláček, Jan; Málková, Andrea; Švadláková, Tereza; Krejsek, Jan; Palička, Vladimír; Řeháček, Vít; Kotingová, Lenka; Borská, Lenka

doi:10.33549/physiolres.934654

Cited by 9 publications

(8 citation statements)

References 45 publications

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“…25 , 57 A substantial body of data found that people with psoriasis had significantly lower levels of fetuin-A than healthy controls. 58–62 This result is in accordance with the findings of another study that reported significantly lower mean serum values of fetuin‑A in patients with psoriasis compared to the healthy control groups. 63 The systemic levels of fetuin‑A are down regulated in patients with psoriasis, most likely due to psoriasis-related inflammation (negative acute phase reactant).…”

Section: Introductionsupporting

confidence: 92%

“… [ 57 ] Uyar et al 2015 136 (70 patients and 66 controls) A significantly lowered fetuin-A levels were found in patients with psoriasis compared with healthy controls. But there were no observed significant correlations between fetuin-A and PASI scores [ 69 ] Borsky et al 2021 50 (28 patients and 22 controls) In the group of persons with psoriasis, there was a significantly decreased serum level of fetuin-A compare to healthy controls [ 58 ] Genc et al 2016 80 (40 Patients and 40 healthy volunteers) Fetuin-A levels in psoriasis patients were found to be low; however, they did not find any association between levels of fetuin-A and disease severity. [ 59 ] Uysal et al 2014 88 participants (58 patients and 30 controls) There was a significantly higher level of fetuin-A in patients with psoriasis than the control group.…”

Section: Introductionmentioning

confidence: 99%

“… 79 A study by Borsky et al assessed the suitability of fetuin A for detection of the early stages of CVD in people with psoriasis and implied that this biomarker could be considered as an appropriate marker in detecting cardiac risk and early stages of CVDs. 58 However, the variable nature of the correlation of fetuin-A in the early and advanced stages of atherosclerosis as well as the biphasic association of fetuin-A with the occurrence of CVD depending on the stage of atherosclerosis may limit its clinical usefulness as a diagnostic biomarker. 79 In order to use fetuin-A in routine clinical practice, additional rigorous and extensive research is needed to provide supporting evidence harmonizing the contradictory results and prove the diagnostic importance of fetuin-A in CVD.…”

Section: Introductionmentioning

confidence: 99%

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Role of Fetuin-A in the Pathogenesis of Psoriasis and Its Potential Clinical Applications

Abebe

Muche

T/Mariam

et al. 2022

CCID

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Fetuin-A is a plasma glycoprotein exhibiting multifaceted physiological and pathological functions. It has been determined to be involved in various essential biological functions, such as regulation of calcium metabolism, osteogenesis, and insulin signaling pathway. It also plays a crucial role in the pathogenesis of several disorders, including psoriasis. Psoriasis is a chronic systemic inflammatory disorder caused by a constellation of environmental, immunogenic, and genetic factors. It has been shown that dysregulation of cytokines mediated immune response is responsible for the development of psoriasis. Several recent publications suggest that dysregulation of fetuin-A correlates with psoriasis disease activities, revealing its putative role in the development of psoriasis. Furthermore, clinical application of fetuin-A as a diagnostic marker, prognostic predictor, and therapeutic target for different clinical conditions is in progress, and some are showing promising outcomes. This review primarily focuses on the current understanding of the role of fetuin-A in the pathogenesis of psoriasis and its potential clinical applications, with a brief highlight of psoriasis epidemiology and burden. The information was gathered systematically from various journals via electronic searches using various search engines: PubMed, Google Scholar, HINARI, and Cochrane Library from inception to 2022. The studies involved were restricted to English language. Conversely, articles written in other languages, studies done on fetuin B, or studies conducted on other dermatological diseases were excluded from the review article.

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Section: Introductionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Role of Fetuin-A in the Pathogenesis of Psoriasis and Its Potential Clinical Applications

Abebe

Muche

T/Mariam

et al. 2022

CCID

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“…Fetuin-A has also been found as a positive acute phase reactant that increases in blood circulation in response to inflammation (Mukhopadhyay et al, 2014). This is supported by the study showing a significant positive relationship between fetuin-A and CRP, indicating the inflammatory activity of fetuin-A (Borsky et al, 2021). Different clinical studies revealed the proinflammatory effects of fetuin-A by demonstrating increased levels of fetuin-A in patients with metabolic syndrome, IR, T2DM, obesity, early-stage atherosclerosis, CVD such as coronary artery disease and peripheral artery disease, and NAFLD (Mathews et al, 2002;Stefan et al, 2006a;Mori et al, 2006;Sardana et al, 2021).…”

Section: Inflammatory and Anti-inflammatory Roles Of Fetuin-amentioning

confidence: 85%

The structure, biosynthesis, and biological roles of fetuin-A: A review

Abebe

Muche

T/Mariam

et al. 2022

Front. Cell Dev. Biol.

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Fetuin-A is a heterodimeric plasma glycoprotein containing an A-chain of 282 amino acids and a B-chain of 27 amino acid residues linked by a single inter-disulfide bond. It is predominantly expressed in embryonic cells and adult hepatocytes, and to a lesser extent in adipocytes and monocytes. Fetuin-A binds with a plethora of receptors and exhibits multifaceted physiological and pathological functions. It is involved in the regulation of calcium metabolism, osteogenesis, and the insulin signaling pathway. It also acts as an ectopic calcification inhibitor, protease inhibitor, inflammatory mediator, anti-inflammatory partner, atherogenic factor, and adipogenic factor, among other several moonlighting functions. Fetuin-A has also been demonstrated to play a crucial role in the pathogenesis of several disorders. This review mainly focuses on the structure, synthesis, and biological roles of fetuin-A. Information was gathered manually from various journals via electronic searches using PubMed, Google Scholar, HINARI, and Cochrane Library from inception to 2022. Studies written in English and cohort, case-control, cross-sectional, or experimental studies were considered in the review, otherwise excluded.

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“…The PASI scores were determined by two dermatological physicians, and their mean value was calculated. Psoriasis severity was evaluated as mild-to-moderate (PASI 10) and severe (PASI ≥ 10) [11].…”

Section: ) Laboratory Datamentioning

confidence: 99%

Association of Monocyte to High-Density Lipoprotein Ratio with FRS and as a Predictor of Cardiovascular Risk in Individuals with Psoriasis

Gu,

Shen,

Jiang

et al. 2023

Preprint

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Background Monocyte to high-density lipoprotein cholesterol Ratio (MHR) has been found to be a new inflammatory biomarker related to cardiovascular diseases (CVDs). The current retrospective study focused on exploring the relationship between MHR and Framingham risk score (FRS) and the prognostic significance of this relationship in mid to high risk CVDs in individuals with psoriasis vulgaris. Methods In the present study, 128 patients with psoriasis vulgaris and 120 normal controls were involved. In addition, neutrophil to high-density lipoprotein cholesterol ratio (NHR), MHR, and neutrophil to lymphocyte ratio (NLR) values of the two groups were retrospectively evaluated. Correlations between MHR and FRS were analyzed. Results NHR, MHR, and NLR values of the patients in psoriasis group with moderate to severe cardiovascular risk noticeably increased relative to the controls (p = 0.018, p = 0.002, p༜0.001, respectively). Furthermore, FRS was positively correlated to MHR, NHR, and NLR among the patients with psoriasis (p = 0.002, p = 0.017, and p < 0.001, respectively). Logistic regression identified age, sex, and MHR as the influencing factors for FRS (p < 0.05). On the basis of the ROC curve, the greatest Youden’s index (0.316) could be obtained at MHR of 0.24, with the relevant sensitivity, specificity, and area under ROC curve of 0.729, 0.413, and 0.662 (95% CI of 0.565, 0.758), respectively. Conclusions MHR was related to FRS, which could be adopted for predicting medium to high risk of CVDs in patients suffering from psoriasis.

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C-Reactive Protein, Chemerin, Fetuin-A and Osteopontin as Predictors of Cardiovascular Risks in Persons With Psoriasis Vulgaris

Cited by 9 publications

References 45 publications

Role of Fetuin-A in the Pathogenesis of Psoriasis and Its Potential Clinical Applications

Role of Fetuin-A in the Pathogenesis of Psoriasis and Its Potential Clinical Applications

The structure, biosynthesis, and biological roles of fetuin-A: A review

Association of Monocyte to High-Density Lipoprotein Ratio with FRS and as a Predictor of Cardiovascular Risk in Individuals with Psoriasis

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