C-reactive protein: clinical applications and proposals for a rational use

Aguiar, Francisco J.B.; Ferreira-Júnior, Mario; Sales, Marcelo Augusto Oliveira de; Cruz-Neto, Luiz M.; Fonseca, Luís; Sumita, Nairo Massakazu; Duarte, Nilo José Coelho; Lichtenstein, A.; Duarte, Alberto J. S.

doi:10.1016/s2255-4823(13)70434-x

Cited by 36 publications

(37 citation statements)

References 27 publications

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“…In low-grade inflammation, there is a constant high concentration of pro-inflammatory cytokines, simultaneously with a reduction in anti-inflammatory cytokines (Ohashi, Shibata, Murohara, & Ouchi, 2014). CRP is widely used to identify the inflammatory status (Aguiar et al, 2013), since it is considered an independent marker of the cardiovascular risk of diseases and atherosclerosis (Libby & Ridker, 2004;Libby, Ridker, & Maseri, 2002). CRP is characterized as an acute-phase protein produced by the liver in response to IL-6 (van Gaal et al, 2006) and high CRP tracks from early life to adulthood (Juonala, Viikari, et al, 2006).…”

Section: Arterial Thickness Obesity and Inflammationmentioning

confidence: 99%

Impact of physical exercise/activity on vascular structure and inflammation in pediatric populations: A literature review

Cayres

Agostinete

Antunes

et al. 2016

Specialist Pediatric Nursing

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Section: Arterial Thickness Obesity and Inflammationmentioning

confidence: 99%

Impact of physical exercise/activity on vascular structure and inflammation in pediatric populations: A literature review

Cayres

Agostinete

Antunes

et al. 2016

Specialist Pediatric Nursing

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“…The level of serum protein content is lowered in M. ferrea treated groups compared to normal group. C-reactive protein (CRP) is an acutephase protein and significantly upregulated during infection, tissue damage and inflammatory disorders 30,31 .…”

Section: Disscusionmentioning

confidence: 99%

Untitled

2018

IJPSR

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Mesua ferrea Linn. (M. ferrea) is an endemic medicinal plant used for the treatment of inflammation, rheumatism, bronchitis, fever, headache, asthma and skin diseases. The aim of this study was to investigate the anti-inflammatory activities of 80% ethanol extract from stem bark of Mesua ferrea Linn. using animal models. Female Wistar albino rats weighing (150-200g) were used for the study. Antiinflammatory activity test was done on rats at two different doses (100 and 200mg/kg) by using carrageenan induced paw edema, cotton pellet induced granuloma and formalin induced paw edema. The results showed that the 80% ethanol extract of stem bark (SBE) 200mg/kg and indomethacin (10mg/kg) exhibited significant reduction of edema in carrageenan induced rat paw edema 39.3 (p < 0.05) and 38.8% (p < 0.01) respectively at the end of 4 h. In cotton pellet granuloma test, SBE (200mg/kg) and indomethacin significantly reduced the wet (42.5 and 40.6% (p < 0.01)) and dry (46.7 and 42.8% (p < 0.01)) weight of the cotton pellet respectively, while in formalin induced paw edema significant reduction in persistent edema from 4 th day to 10 th day of the Investigation was observed. SBE 200mg/kg exhibited significant antiinflammatory effect i.e., 40.3% (p < 0.05) when compared to indomethacin 33.3% (p < 0.05). The results obtained in this study indicated that the 80% ethanol extract of Mesua ferrea Linn. possess potent anti-inflammatory activity in both acute and chronic models.

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“…There are many inflammatory markers. One of the inflammatory markers is C-reactive protein (CRP), which is an acute-phase reactant produced by the liver and it is an extremely sensitive marker of systemic inflammation and also powerful predictor of cardiovascular disease [9][10][11]. CRP and acute phase-response were first discovered in 1930, as precipitation was observed with addition of pneumococcal C-polysaccharide to serum of a patient with pneumonia [12].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Inflammatory Status in Type 2 Diabetes Mellitus Patients

Priyadharshini

Vishnupriya

2018

Asian J Pharm Clin Res

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Objective: The metabolic disorder, Type 2 diabetes mellitus (T2DM), is a major health problem which is the risk factor for the development of cardiovascular disease, cerebrovascular accident, renal failure, and other macrovascular diseases. Inflammation is the major pathogenesis of all the above conditions. Therefore, there is a need to assess the inflammatory status using simple and reliable marker which would help to diagnose the disease and assess the prognosis of the disease. Hence, the aim of the current study is to estimate the level of simple inflammatory marker, C-reactive protein (CRP) in Type 2 diabetes individual.Materials and Method: Fifty patients, reporting to Saveetha Dental College and Hospitals, were enrolled in the study which includes 25 patients with T2DM and 25 healthy individuals. 5 ml of venous blood was collected and centrifuged. Then, it is analyzed for fasting blood sugar (FBS), glycated hemoglobin (HbA1c), and CRP using the standard kit method. The data obtained were subjected to statistical analysis using the SPSS software.Results: The mean FBS, HbA1c, and CRP levels were higher in T2DM patients in comparison to healthy individuals. The serum FBS, HbA1c, and CRP levels in the control group and T2DM group were 85.08±8.47, 4.27±0.63, and 6.51±0.83 and 168, 7.38±0.9, and 27.23±19.06, respectively. There was a significant (p=0.000) difference in the mean CRP levels of the above groups.Conclusion: CRP level were consistently higher in T2DM individuals; hence, it could be a simple and reliable marker to assess the inflammatory status of the diabetic individuals.

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C-reactive protein: clinical applications and proposals for a rational use

Cited by 36 publications

References 27 publications

Impact of physical exercise/activity on vascular structure and inflammation in pediatric populations: A literature review

Impact of physical exercise/activity on vascular structure and inflammation in pediatric populations: A literature review

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Assessment of Inflammatory Status in Type 2 Diabetes Mellitus Patients

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