C‐reactive protein concentration in dogs with primary immune‐mediated hemolytic anemia

Griebsch, Christine; Arndt, Gisela; Raila, Jens; Schweigert, Florian J.; Kohn, Barbara

doi:10.1111/j.1939-165x.2009.00146.x

Cited by 54 publications

(69 citation statements)

References 16 publications

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“…26 Despite the significant association between serum CRP concentrations and odds of death in the present study, results of ROC curve analysis indicated that the discriminative ability of CRP concentration alone in predicting outcome was only moderately accurate. This is in accordance with findings of several oth-er clinical studies 27,[38][39][40] that indicated circulating CRP concentration alone does not correspond to outcome.…”

Section: Discussionsupporting

confidence: 79%

Evaluation of the use of serum C-reactive protein concentration to predict outcome in puppies infected with canine parvovirus

McClure¹,

Schoor²,

Thompson³

et al. 2013

javma

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Objective—To evaluate associations of serum C-reactive protein (CRP) concentration with duration of hospitalization and with outcome in puppies with canine parvoviral enteritis. Design—Prospective observational study. Animals—79 client-owned puppies with naturally acquired canine parvovirus infection. Procedures—All puppies received supportive care. Serum CRP concentration was measured at the time of admission, approximately every 10 to 12 hours for the first 48 hours, and then every 24 hours until discharge from the hospital or death. Associations between outcome and CRP concentration at various time points or changes in CRP concentration over time were assessed via multiple logistic regression. Associations of CRP concentration with survival time and duration of hospitalization among survivors were estimated with Cox proportional hazards regression. Use of CRP concentration to predict outcome was evaluated by means of receiver operating characteristic curve analysis. Results—Serum CRP concentrations at admission and 12 and 24 hours later were positively associated with odds of death, and CRP concentrations at 12 and 24 hours after admission were negatively associated with survival time for puppies. Among survivors, duration of hospitalization was positively associated with CRP concentrations at 12, 24, and 36 hours after admission. Sensitivity and specificity of CRP concentration to differentiate between survivors and nonsurvivors at 24 hours after admission were 86.7% and 78.7%, respectively (considered moderately accurate). Conclusions and Clinical Relevance—Although serum CRP concentration was associated with outcome in puppies with canine parvovirus enteritis, it did not prove to be a good predictor of outcome when used alone.

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Section: Discussionsupporting

confidence: 79%

Evaluation of the use of serum C-reactive protein concentration to predict outcome in puppies infected with canine parvovirus

McClure¹,

Schoor²,

Thompson³

et al. 2013

javma

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show abstract

“…C‐reactive protein is a positive type II acute phase protein expressed in the liver69 in response to infection, inflammation, or cancer,70 and the serum CRP concentration is a nonspecific marker of inflammation 71, 72, 73, 74, 75, 76, 77, 78, 79, 80. Quantification of canine CRP in serum can be done using several assay formats,81, 82, 83, 84, 85, 86, 87, 88 all of which have a reference interval of approximately 0–8 mg/L.…”

Section: Biomarkers In Chronic Inflammatory Enteropathies Of Dogsmentioning

confidence: 99%

Clinical utility of currently available biomarkers in inflammatory enteropathies of dogs

Heilmann

Steiner

2018

Veterinary Internal Medicne

108

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Chronic inflammatory enteropathies (CIE) in dogs are a group of disorders that are characterized by chronic persistent or recurrent signs of gastrointestinal disease and histologic evidence of mucosal inflammation. These CIEs are classified as either food‐responsive, antibiotic‐responsive, or immunosuppressant‐responsive enteropathy. Patients not clinically responding to immunomodulatory treatment are grouped as nonresponsive enteropathy and dogs with intestinal protein loss as protein‐losing enteropathy. Disease‐independent clinical scoring systems were established in dogs for assessment of clinical disease severity and patient monitoring during treatment. Histopathologic and routine clinicopathologic findings are usually not able to distinguish the subgroups of CIE. Treatment trials are often lengthy and further diagnostic tests are usually at least minimally invasive. Biomarkers that can aid in defining the presence of disease, site of origin, severity of the disease process, response to treatment, or a combination of these would be clinically useful in dogs with CIE. This article summarizes the following biomarkers that have been evaluated in dogs with CIE during the last decade, and critically evaluates their potential clinical utility in dogs with CIE: functional biomarkers (cobalamin, methylmalonic acid, folate, α1‐proteinase inhibitor, immunoglobulin A), biochemical biomarkers (C‐reactive protein, perinuclear anti‐neutrophilic cytoplasmic antibodies, 3‐bromotyrosine, N‐methylhistamine, calprotectin, S100A12, soluble receptor of advanced glycation end products, cytokines and chemokines, alkaline phosphatase), microbiomic biomarkers (microbiome changes, dysbiosis index), metabolomic biomarkers (serum metabolome), genetic biomarkers (genomic markers, gene expression changes), and cellular biomarkers (regulatory T cells). In addition, important performance criteria of diagnostic tests are briefly reviewed.

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“…Additionally, interaction of P-selectin with its receptor, PSGL-1, stimulates the production of thrombogenic microparticles from leucocytes (mainly monocytes), which together with platelets and endothelial cells play an important role in thrombogenesis (Ramacciotti et al 2009;Wakefield et al 2009). The presence of an inflammatory response in dogs with IMHA is also evidenced by the activity of chemotaxins, such as monocyte chemoattractant protein-1 and granulocyte macrophage colony-stimulating factor, and acutephase proteins (Tecles et al 2005;Griebsch et al 2009;Mitchell et al 2009;Duffy et al 2010;Yuki et al 2010). …”

Section: Mortality and Thromboembolismmentioning

confidence: 99%

“…These diseases are rare, and spherocytosis is generally accepted as pathognomonic for IMHA. Spherocytes are quantified microscopically, usually as counts per high-power field (Weiss 1984;Griebsch et al 2009Griebsch et al , 2010. Potential disadvantages of this method are a high interobserver variability and the fact that the number of spherocytes per high-power field depends on the haematocrit.…”

Section: Diagnostic Testingmentioning

confidence: 99%

Canine idiopathic immune-mediated haemolytic anaemia: a review with recommendations for future research

Piek

2011

Veterinary Quarterly

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C‐reactive protein concentration in dogs with primary immune‐mediated hemolytic anemia

Abstract: Serum CRP concentration was markedly increased in dogs with primary IMHA. CRP concentration did not differ based on patient survival, but might be a marker for long-term monitoring of these patients.

Cited by 54 publications

References 16 publications

Evaluation of the use of serum C-reactive protein concentration to predict outcome in puppies infected with canine parvovirus

Evaluation of the use of serum C-reactive protein concentration to predict outcome in puppies infected with canine parvovirus

Clinical utility of currently available biomarkers in inflammatory enteropathies of dogs

Canine idiopathic immune-mediated haemolytic anaemia: a review with recommendations for future research

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