C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) as inflammation markers in elderly patients with stable chronic obstructive pulmonary disease (COPD)

Corsonello, Andrea; Pedone, Claudio; Battaglia, Salvatore; Paglino, Giuseppe; Bellia, Vincenzo; Incalzi, Raffaele Antonelli

doi:10.1016/j.archger.2010.10.015

Cited by 26 publications

(23 citation statements)

References 39 publications

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“…It was further established that patients presenting with acute exacerbation had higher levels of acute phase proteins like CRP than stable patients [20] . In our study, CRP is inversely correlated with FEV1(r= -0.284, p=0.004) that was statistically significant which is in accordance with study conducted by SJ Wu,PChen et al [21] , Andrea Corsonello et al [22] and Yihua Lin [23] who also found negative correlation of CRP with FEV1. Study by Rakesh Kumar and P Nigam [24] concluded that correlation of CRP with FEV1 was negative in cases presenting as acute exacerbation.…”

Section: Discussionsupporting

confidence: 81%

Study of Prognostic Association of C-Reactive Protein (A Biomarker) with Clinically Important Predictors of Outcome in Stable and Unstable COPD Patients

2016

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Background: COPD is characterized by persistent airflow limitation that is progressive and is associated with enhanced chronic inflammatory response in the airways to noxious particles or gases. It has both systemic and pulmonary effects. Since COPD deaths estimated to increase by 30% in next 10 years, cost of treatment will be a heavy burden on global economy. The costs are proportional to pulmonary and extra pulmonary components of the disease. Methods: In this study, we examined 100 patients of COPD, out of which 80 were stable and 20 were unstable. Results: CRP levels were found to be increased in cases more than in controls (13.55+10.83 vs. 2.07+0.82 mg/lit, p<0.001), the levels being higher in unstable patients than in stable patients (33.78+7.74 vs. 8.50+1.81 mg/lit, p<0.001). We also submitted the patients to MMRC dyspnoea scale and found that CRP is positively correlated with MMRC dyspnoea scale (r=0.638, p<0.001) and was inversely correlated with 6-minute walk distance (r= -0.364, p<0.001). There was a significant positive correlation of CRP with BODE index (r=0.780, p<0.001). Conclusion: The study is valuable in detecting the severity of COPD cases both in stable and unstable conditions and to forecast the future morbidity and mortality outcome of such cases.

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Section: Discussionsupporting

confidence: 81%

Study of Prognostic Association of C-Reactive Protein (A Biomarker) with Clinically Important Predictors of Outcome in Stable and Unstable COPD Patients

2016

AIMDR

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“…ESR decrease was shown with AE‐COPD treatment . Another study reported that ‘ESR might be more useful as a marker of COPD exacerbations’ . The clinical variables that predict mortality in patients with COPD were significantly improved with WBC .…”

Section: Discussionmentioning

confidence: 98%

Alterations of the neutrophil–lymphocyte ratio during the period of stable and acute exacerbation of chronic obstructive pulmonary disease patients

Taylan

Demir

Kaya

et al. 2015

Clinical Respiratory J

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“…But Kurashima et al6 reported CPFE had better survival compared with IPF. ESR and CRP might show as systemic inflammatory marker in chronic obstructive pulmonary disease18. CRP increases as FEV 1 % worsens19.…”

Section: Discussionmentioning

confidence: 99%

Annual Change in Pulmonary Function and Clinical Characteristics of Combined Pulmonary Fibrosis and Emphysema and Idiopathic Pulmonary Fibrosis: Over a 3-Year Follow-up

et al. 2014

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BackgroundCombined pulmonary fibrosis and emphysema (CPFE) have different pulmonary function tests (PFTs) and outcomes than idiopathic pulmonary fibrosis (IPF). The intention of this study was to identify unknown differences between CPFE and IPF by a retrospective comparison of clinical data including baseline and annual changes in pulmonary function, comorbidities, laboratory findings, clinical characteristics and cause of hospitalization.MethodsThis study retrospectively enrolled patients with CPFE and IPF who had undergone PFTs once or several times per year during a follow-up period of three years. Baseline clinical characteristics and the annual changes in the pulmonary function during the follow-up period were compared between 26 with CPFE and 42 patients with IPF.ResultsThe baseline ratio of forced expiratory volume in one second to forced vital capacity (FEV1/FVC%) in patients with CPFE was lower than that in patients with IPF (78.6±1.7 vs. 82.9±1.1, p=0.041). The annual decrease in FEV1/FVC in the CPFE was significantly higher than in the IPF. The annual decreases in diffusion capacity of carbon monoxide and FVC showed no significant differences between the two groups. The symptom durations of cough and sputum were in the CPFE significantly lower than in the IPF. The serum erythrocyte sedimentation rate level at the acute stage was significantly higher than in the IPF. There were no significant differences in the hospitalization rate and pneumonia was the most common cause of hospitalization in both study groups.ConclusionThe annual decrease of FEV1/FVC was in patients with CPFE significantly higher than in the patients with IPF.

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C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) as inflammation markers in elderly patients with stable chronic obstructive pulmonary disease (COPD)

Cited by 26 publications

References 39 publications

Study of Prognostic Association of C-Reactive Protein (A Biomarker) with Clinically Important Predictors of Outcome in Stable and Unstable COPD Patients

Study of Prognostic Association of C-Reactive Protein (A Biomarker) with Clinically Important Predictors of Outcome in Stable and Unstable COPD Patients

Alterations of the neutrophil–lymphocyte ratio during the period of stable and acute exacerbation of chronic obstructive pulmonary disease patients

Annual Change in Pulmonary Function and Clinical Characteristics of Combined Pulmonary Fibrosis and Emphysema and Idiopathic Pulmonary Fibrosis: Over a 3-Year Follow-up

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