C‐Reactive protein: Current status and future perspectives

Abstract

This review encompasses all aspects of re-Reactive protein analysis relative to simplicity cent C-Reactive protein studies. Emphasis has and sensitivity. The responses of C-Reactive been in the areas of (1) the physical, chemical, protein in various diseases and its future prosand potential functions of C-Reactive protein; pects are also discussed in this review. and (2) the pass and recent procedures of C-

Levels of C-reactive protein in serum samples from healthy children and adults in São Paulo, Brazil

“…According to Hokama and Nakamura (33), serum CRP levels appear to progressively increase with age. We did not find a progressive increase in CRP levels in sera of children aged 1 to 14 years, but the data obtained revealed that the CRP concentration in the sera from blood donors that represent selectively healthy adults was significantly higher than that observed in healthy schoolchildren.…”

Assessment of Inflammatory Markers and Lipid Profile Levels in Normotensive, Primary Hypertensive and Secondary Hypertensive Male Obese Individuals

“…According to Hokama and Nakamura, serum CRP levels increase progressively with age. 18 Increasing age, smoking, symptoms of chronic bronchitis, Helicobacter pylori and chlamydia infection and basal metabolic index were all associated with raised levels of CRP, so we excluded smokers and disordered persons. Alcohol consumption is associated with a decreased probability of elevated CRP supporting an anti-inflammatory mechanism, by which a moderate alcohol use might protect against cardiovascular death.…”

The Uniqueness of Achatina fulica in its Evolutionary Success

“…It belongs to a protein family called pentraxin (from the Greek words "penta" five and "ragos," berries) that constitutes a phylogenetically ancient family of proteins exhibiting a remarkable conservation of structure and binding reactivities. The presence of CRP has been reported from a wide range of different animals such as monkey, dog, goat, rabbit, rat, mice, domestic fowl, fish, shark and lumpsucker among vertebrates and horseshoe crab [56] and A. fulica [57] among the invertebrates. The finding that CRP is a major blood constituent of primitive animals, for example, horseshoe crab, L. polyphemus and dogfish argues strongly for an important role of this protein.…”

“…Besides assessing different toxicological parameters, anti-bacterial property of the innate immune molecule, namely C-reactive protein (CRP) isolated from A. fulica, was also determined. CRP is a prototypic acute phase reactant, which is a phylogenetically conserved protein expressed in invertebrates such as arthropods [56], molluscs [58] and also in all vertebrates [64]. In Limulus, an arthropod, CRP acts as a main front-line innate immune molecule [59] which may be the key to a powerful defense mechanism of these animals against microbial infections that are potentially lethal in other organisms.…”