C-Reactive Protein Expression Is Up-regulated in Apical Lesions of Endodontic Origin in Association with Interleukin-6

Garrido, Mauricio; Dezerega, Andrea; Bordagaray, María José; Reyes, María Isabel Pávez; Vernal, Rolando; Melgar-Rodríguez, Samantha; Ciuchi, P.; Paredes, Rodolfo; García-Sesnich, Jocelyn; Ahumada-Montalva, Pablo; Hernández, Marcela

doi:10.1016/j.joen.2014.12.021

Cited by 30 publications

(29 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…CRP mRNA expression has been identified in healthy periodontal ligament and was overexpressed in apical lesions of endodontic origin from asymptomatic periodontitis patients along with IL‐6, suggesting a local synthesis in apical tissues (Garrido et al . ).…”

Section: Discussionmentioning

confidence: 97%

“…In line with this, high CRP mRNA expression and protein levels were reported in apical lesions of endodontic origin (Garrido et al . ). Based on its potent pro‐inflammatory properties, it might stimulate local periodontal/periapical inflammation.…”

Section: Discussionmentioning

confidence: 97%

“…, Garrido et al . ), compared to previous studies where 10‐100 ng mL −1 of IL‐6 and IL‐6R was used (Hosokawa et al . , Shibata et al .…”

Section: Discussionmentioning

confidence: 98%

“…, Garrido et al . ). Although it has presumably been attributed to originate from the systemic circulation, its source remains unclear.…”

Section: Introductionmentioning

confidence: 97%

See 3 more Smart Citations

Human periodontal ligament fibroblasts synthesize C‐reactive protein and Th‐related cytokines in response to interleukin (IL)‐6 trans‐signalling

et al. 2017

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

See 2 more Smart Citations

Human periodontal ligament fibroblasts synthesize C‐reactive protein and Th‐related cytokines in response to interleukin (IL)‐6 trans‐signalling

et al. 2017

View full text Add to dashboard Cite

show abstract

“…From the results, they concluded that in hypertensive patients with severe periodontitis, nonsurgical periodontal therapy was equally effective. Garrido et al 23 assessed the expression of coiled coil-rich proteins in patients with apical lesions of endodontic origin. They included patients with asymptomatic apical periodontitis and healthy controls and evaluated their IL-6 and CRP levels.…”

Section: Discussionmentioning

confidence: 99%

Assessment of C-reactive Proteins, Cytokines, and Plasma Protein Levels in Hypertensive Patients with Apical Periodontitis

Rashmi¹,

Galhotra

Goel

et al. 2017

The Journal of Contemporary Dental Practice

View full text Add to dashboard Cite

Introduction: Chronic apical periodontitis (CAP) manifests mostly as periapical radiolucency. Various inflammatory mediators play a significant role in the pathogenesis of apical periodontitis. In acute inflammatory conditions, C-reactive proteins (CRP) and fibrinogen show a rise in their concentrations. In chronic diseases with high inflammatory components, an increased prevalence of hypertension has been observed. Hence, we assessed the association of CAP and plasma levels of various inflammatory markers (CRP,, and fibrinogen) in severely hypertensive patients. Materials and methods:This study was conducted in the conservative wing of the institute and included assessment of 250 hypertensive patients with apical periodontitis. With the help of periapical radiographs and clinical examination, the assessment of following parameters was done: Amount of teeth present, visible plaque index, periodontal pocket probing depth, clinical attachment level, bleeding on probing, presence/absence of carious lesions, which included assessment of caries in crown portion, in the root portion, and residual tooth roots (RR), presence of CAP from each patient; 8 mm of venous blood was collected in the morning for the assessment of plasma levels of IL-6, CRP, and fibrinogen levels. Immediate collection and processing of the samples were done in the hospital laboratory.All the results were analyzed by Statistical Package for the Social Sciences software.Results: Out of 250, 155 patients were females. Mean plasma levels of CRP observed in our study were 0.8 mg/dL. Mean plasma levels of IL-6 and fibrinogen were found to be 3.3 and 337.1 mg/dL respectively. A significant correlation was observed while comparing mean body mass index (BMI), RR, and CAP in hypertensive patients. While comparing the mean plasma IL-6 levels, mean BMI, and CAP in the patients, significant results were obtained. Significant correlation was observed while comparing the mean BMI and CAP in hypertensive patients. Conclusion:Systemic levels of CRP, IL-6, and fibrinogen levels are influenced by the presence of CAP in hypertensive patients. Clinical significance:In hypertensive patients, CAP alters the systemic levels of various inflammatory markers.

show abstract

Can apical periodontitis affect serum levels of CRP, IL-2, and IL-6 as well as induce pathological changes in remote organs?

Zhang

Huang

et al. 2015

Clin Oral Invest

View full text Add to dashboard Cite

show abstract

C-Reactive Protein Expression Is Up-regulated in Apical Lesions of Endodontic Origin in Association with Interleukin-6

Cited by 30 publications

References 25 publications

Human periodontal ligament fibroblasts synthesize C‐reactive protein and Th‐related cytokines in response to interleukin (IL)‐6 trans‐signalling

Human periodontal ligament fibroblasts synthesize C‐reactive protein and Th‐related cytokines in response to interleukin (IL)‐6 trans‐signalling

Assessment of C-reactive Proteins, Cytokines, and Plasma Protein Levels in Hypertensive Patients with Apical Periodontitis

Can apical periodontitis affect serum levels of CRP, IL-2, and IL-6 as well as induce pathological changes in remote organs?

Contact Info

Product

Resources

About