C-reactive protein in HIV-infected patients—could it be a marker of immunosuppression?

Maruthamuthu, S.; Cecelia, Anitha J.; Pulimi, Sandeep; Ameedha, Liaquath; Srinivas, Chakravarthy Narasimhachar; Solomon, Sunil S.; Narayan, Ashwin; Balakrishnan, Pachamuthu; Murugavel, Kailapuri G.; Solomon, Suniti; Kumarasamy, Nagalingeswaran

doi:10.1016/j.cca.2006.05.040

Cited by 4 publications

(4 citation statements)

References 14 publications

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“…C-reactive protein (CRP) is a prophylactic acute-phase plasma protein and a non-specific marker of systemic inflammation that is stimulated by cytokines such as IL-6, IL-1, and TNF to be produced in the liver. The levels of CRP were significantly higher in INRs than that in IRs ( 217 ), and were inversely associated with CD4 + T cell counts ( 192 ). For hypersensitive CRP (hsCRP), there was no difference between INRs and IRs ( 26 ).…”

Section: Soluble Mediators and Cytokinesmentioning

confidence: 99%

Cellular and molecular insights into incomplete immune recovery in HIV/AIDS patients

Yan

Xiao

et al. 2023

Front. Immunol.

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Highly active antiretroviral therapy (ART) can effectively inhibit virus replication and restore immune function in most people living with human immunodeficiency virus (HIV). However, an important proportion of patients fail to achieve a satisfactory increase in CD4+ T cell counts. This state is called incomplete immune reconstitution or immunological nonresponse (INR). Patients with INR have an increased risk of clinical progression and higher rates of mortality. Despite widespread attention to INR, the precise mechanisms remain unclear. In this review, we will discuss the alterations in the quantity and quality of CD4+ T as well as multiple immunocytes, changes in soluble molecules and cytokines, and their relationship with INR, aimed to provide cellular and molecular insights into incomplete immune reconstitution.

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Section: Soluble Mediators and Cytokinesmentioning

confidence: 99%

Cellular and molecular insights into incomplete immune recovery in HIV/AIDS patients

Yan

Xiao

et al. 2023

Front. Immunol.

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“…Our study also demonstrates that HIV infection, regardless of pregnancy type does not affect CRP concentration (p = 0.371) with CRP levels being higher in HIV infection than HIV naïve groups. It is controversial that this acute phase protein is elevated in HIV infection compared to HIV naïve patients [42,43]. Previous studies have reported that the high apoptosis, as occurs in HIV infection may promote the production of CRP, a scavenger for chromatin released from apoptotic cells [44,45].…”

Section: -Reactive Proteinmentioning

confidence: 99%

The role of C – reactive protein and Pentraxin 3 in HIV-associated pre-eclampsia

Moodley,

Pillay,

Govender

et al. 2023

Preprint

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Objectives To compare the expression of inflammatory proteins, pentraxin 3 and c-reactive proteins in HIV-associated normotensive and preeclamptic pregnancies. Methods Both HIV status (HIV-positive and HIV-negative) and pregnancy type (normotensive pregnant and preeclampsia) were used to stratify the study population (n = 80). Using a ProcartaPlex™ immunoassay technique, the plasma concentrations of pentraxin 3 and c-reactive protein were measured. Results An up-regulation of c-reactive protein was demonstrated in pre-eclamptic versus normotensive women; HIV-positive versus HIV-negative, and across the study population. albeit non-significant. Pentraxin 3 was significantly higher in preeclamptic versus normotensive women (p < 0.0001), irrespective of HIV status. However, no significance was found in HIV status, regardless of pregnancy type. When compared across all groups pentraxin 3 concentrations was significantly different between normotensive HIV-negative versus pre-eclamptic HIV-negative groups (p = 0.0001); and normotensive HIV-negative versus pre-eclamptic HIV-positive groups (p = 0.0049). Conclusions This novel study demonstrated pentraxin 3 concentrations to be significantly higher in pre-eclampsia compared to normotensive pregnant women, emanating from oxidative stress and inflammation. C-reactive protein was higher in the normotensive pregnant women compared to pre-eclampsia. This difference may stem from hepatic dysfunction, gestational age, disease severity, interleukin-6 production, and/or sample size.

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“…9 We also found an increase in the levels of CRP, CD4þ lymphocyte and albumin after 6 months of antiretroviral therapy that interestingly is in line with our previous study. 10 While this study represents the alterations in acutephase proteins among HIV-1 infected persons with and without HAART for over a 6-month follow-up, our study has certain limitations. The study lacks in defining the clinical course of participants especially in regards to describing opportunistic infections, which could likely influence the acute-phase components and the complement system.…”

mentioning

confidence: 96%

Alterations in acute-phase proteins among HIV-1 infected persons receiving generic HAART in southern India

Maruthamuthu

Srinivas

Shankar

et al. 2009

Journal of Infection

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C-reactive protein in HIV-infected patients—could it be a marker of immunosuppression?

Cited by 4 publications

References 14 publications

Cellular and molecular insights into incomplete immune recovery in HIV/AIDS patients

Cellular and molecular insights into incomplete immune recovery in HIV/AIDS patients

The role of C – reactive protein and Pentraxin 3 in HIV-associated pre-eclampsia

Alterations in acute-phase proteins among HIV-1 infected persons receiving generic HAART in southern India

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