C-Reactive Protein in Semen and Serum of Men with Chronic Prostatitis

Girgis, S. M.; Ekladios, E. M.; Iskandar, Ranu; El-Haggar, Sahar Mohamed; Moemen, N.; Elkassem, Samer

doi:10.1111/j.1439-0272.1983.tb00129.x

Cited by 8 publications

(4 citation statements)

References 6 publications

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“…Chronic inflammation may play a role in the occurrence of residual urgency in BPH patients (St Sauver et al., ). With CRP ≥3.0 mg/L, the urinary symptoms in prostatitis patients are more intense, in particular, urgency becomes apparent (Girgis et al., ). In the present research, there were increased levels of TNF‐α and CRP in plasma in T 2 plus aluminium hydroxide adjuvant group.…”

Section: Discussionmentioning

confidence: 99%

Establishment of experimental autoimmune prostatitis model by T₂peptide in aluminium hydroxide adjuvant

et al. 2017

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A mouse model was developed to simulate the clinical features of chronic prostatitis/chronic pelvic pain syndrome using peptide (T ). Forty C57BL/6 mice were divided into four groups of 10 mice each, averagely and randomly. T plus aluminium hydroxide adjuvant group was given subcutaneous injection with the emulsion mixture of T and aluminium hydroxide adjuvant, the T group with T , the aluminium hydroxide adjuvant group with aluminium hydroxide adjuvant and the normal control group with 0.9/% NaCl solution. Haematoxylin andeosin staining was used to observe the inflammation of the prostate. Plasma levels of TNF-α and CRP were detected by ELISA kit. The expression of IL-1βin the prostate was investigated by immunohistochemistry. The statistical differences between the groups were compared by t test. Histopathological analyses demonstrated that prostate lesions were most severe in the group immunised with T plus aluminium hydroxide adjuvant. Plasma levels of TNF-α and CRP were statistically elevated compared with control groups. The expression levels of IL-1β in the prostate were more obvious than control groups. T in aluminium hydroxide adjuvant subcutaneous injection could successfully set up experimental autoimmune prostatitis in C57BL/6 mice. This murine model would be greatly beneficial to further comprehend the aetiology, pathogenesis and explicit treatment of CP/CPPS.

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Section: Discussionmentioning

confidence: 99%

Establishment of experimental autoimmune prostatitis model by T₂peptide in aluminium hydroxide adjuvant

et al. 2017

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“…55 Interestingly, it is highly abundant in ram seminal plasma 2 and was one of the most abundant proteins we identified in lysates of ejaculated ram spermatozoa; however, increased levels of seminal plasma BDH2 have previously been linked to below average sperm motility (<80%). 56 C Reactive Protein (CRP) has previously been identified in the semen of men with chronic prostatitis 57 but was not present in sperm lysates from healthy donors. 20,37,38 CRP is a blood serum protein produced by hepatocytes and has pleiotropic effects on the immune system, with contextual pro and anti-inflammatory activity, 58 which could indicate an immune based role when present on ejaculated spermatozoa.…”

Section: Conserved and Species Specific Sperm Proteinsmentioning

confidence: 99%

Proteomic Investigation of Ram Spermatozoa and the Proteins Conferred by Seminal Plasma

et al. 2016

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Sperm proteomes have emerged for several species; however, the extent of species similarity is unknown. Sheep are an important agricultural species for which a comprehensive sperm proteome has not been produced. In addition, potential proteomic factors from seminal plasma that may contribute to improved fertility after cervical insemination are yet to be explored. Here we use liquid chromatography-tandem mass spectrometry to investigate the proteome of ejaculated ram spermatozoa, with quantitative comparison to epididymal spermatozoa. We also present a comparison to published proteomes of five other species. We identified 685 proteins in ejaculated ram spermatozoa, with the most abundant proteins involved in metabolic pathways. Only 5% of ram sperm proteins were not detected in other species, which suggest highly conserved structures and pathways. Of the proteins present in both epididymal and ejaculated ram spermatozoa, 7% were more abundant in ejaculated spermatozoa. Only two membrane-bound proteins were detected solely in ejaculated sperm lysates: liver enriched gene 1 (LEG1/C6orf58) and epidermal growth factor-like repeats and discoidin I-like domains 3 (EDIL3). This is the first evidence that despite its relatively complex proteomic composition, seminal plasma exposure leads to few novel proteins binding tightly to the ram sperm plasma membrane.

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“…CRP levels have been demonstrated to be elevated in the seminal plasma of patients with infection and chronic prostatitis. [23] The local inflammatory response is a physiological answer to an infection or injury that stimulates the immune system to produce an increased amount of in-flammatory markers. During the acute phase, circulating concentrations of SAA and CRP could increase as much as 1000-fold.…”

Section: Discussionmentioning

confidence: 99%

High lipid diet and the expression of proinflammatory markers in testis

Pencheva¹,

Koeva²,

Dimitrov³

et al. 2022

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Introduction: Obesity is defined as chronic low-grade inflammation which is manifestation of the cellular response to a variety of stressful situations leading to organ and tissue damage. А high lipid diet could be assumed to be the trigger mechanism for the development of inflammatory processes leading to a disorder in the immune tolerance in the testis. Aim: The present study aimed at demonstrating the expression of inflammatory markers in the testis by a model of a high lipid diet and the possible effect on spermatogenesis. Materials and methods: Male Wistar rats were used in the study divided into two groups: a control group fed standard rodent food and an experimental group receiving high lipid food for 14 weeks. Routine histological techniques, immunohistochemical reactions for proinflammatory markers and morphometric analysis were performed to examine the testis preparations. Results: The high lipid diet caused a low-grade inflammation in the testis in the experimental group, which was confirmed by the increase of proinflammatory markers: the C-reactive protein, serum amyloid A, and interleukin-4, and by the elevated levels of angiotensin-converting enzyme in the experimental versus control groups in a rat experimental model. Conclusions: Our results suggest that a high lipid diet might be a possible cause for the idiopathic infertility in men.

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C-Reactive Protein in Semen and Serum of Men with Chronic Prostatitis

Cited by 8 publications

References 6 publications

Establishment of experimental autoimmune prostatitis model by T₂peptide in aluminium hydroxide adjuvant

Establishment of experimental autoimmune prostatitis model by T₂peptide in aluminium hydroxide adjuvant

Proteomic Investigation of Ram Spermatozoa and the Proteins Conferred by Seminal Plasma

High lipid diet and the expression of proinflammatory markers in testis

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C-Reactive Protein in Semen and Serum of Men with Chronic Prostatitis

Cited by 8 publications

References 6 publications

Establishment of experimental autoimmune prostatitis model by T2peptide in aluminium hydroxide adjuvant

Establishment of experimental autoimmune prostatitis model by T2peptide in aluminium hydroxide adjuvant

Proteomic Investigation of Ram Spermatozoa and the Proteins Conferred by Seminal Plasma

High lipid diet and the expression of proinflammatory markers in testis

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Establishment of experimental autoimmune prostatitis model by T₂peptide in aluminium hydroxide adjuvant

Establishment of experimental autoimmune prostatitis model by T₂peptide in aluminium hydroxide adjuvant