C-reactive protein isoforms as prognostic markers of COVID-19 severity

Molins, Blanca; Figueras‐Roca, Marc; Valero, Oliver; Llorenç, Víctor; Romero-Vázquez, Sara; Sibila, Oriol; Adán, Alfredo; García-Vidal, Carolina; Soriano, Álex

doi:10.3389/fimmu.2022.1105343

Cited by 19 publications

(14 citation statements)

References 36 publications

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“…In fact, we found increased mCRP levels to be significantly associated with increased pCRP levels. In this line, systemic mCRP has been found significantly increased in acute inflammatory diseases with higher pCRP levels such as acute myocardial infarction ( 17 ) or COVID-19 ( 21 ). Most AMD patients in our cohort, as in general population, were female.…”

Section: Discussionmentioning

confidence: 98%

C-reactive protein-complement factor H axis as a biomarker of activity in early and intermediate age-related macular degeneration

Giralt,

Figueras-Roca,

Eguileor

et al. 2024

Front. Immunol.

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PurposeTo determine and compare the serum levels of complement Factor H (FH), monomeric C-Reactive Protein (mCRP) and pentameric C-Reactive protein (pCRP) in patients with age-related macular degeneration (AMD) and to correlate them with clinical, structural and functional parameters.MethodsCross-sectional observational study. One hundred thirty-nine individuals (88 patients and 51 healthy controls) from two referral centers were included and classified into three groups: early or intermediate AMD (n=33), advanced AMD (n=55), and age and sex matched healthy controls (n=51). Serum levels of FH, mCRP, and pCRP were determined and correlated with clinical and imaging parameters.ResultsPatients with intermediate AMD presented FH levels significantly lower than controls [186.5 (72.1-931.8) µg/mL vs 415.2 (106.1-1962.2) µg/mL; p=0.039] and FH levels <200 µg/mL were associated with the presence of drusen and pigmentary changes in the fundoscopy (p=0.002). While no differences were observed in pCRP and mCRP levels, and mCRP was only detected in less than 15% of the included participants, women had a significantly higher detection rate of mCRP than men (21.0% vs. 3.8%, p=0.045). In addition, the ratio mCRP/FH (log) was significantly lower in the control group compared to intermediate AMD (p=0.031). Visual acuity (p<0.001), macular volume (p<0.001), and foveal thickness (p=0.034) were significantly lower in the advanced AMD group, and choroidal thickness was significantly lower in advanced AMD compared to early/intermediate AMD (p=0.023).ConclusionIntermediate AMD was associated in our cohort with decreased serum FH levels together with increased serum mCRP/FH ratio. All these objective serum biomarkers may suggest an underlying systemic inflammatory process in early/intermediate AMD patients.

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Section: Discussionmentioning

confidence: 98%

C-reactive protein-complement factor H axis as a biomarker of activity in early and intermediate age-related macular degeneration

Giralt,

Figueras-Roca,

Eguileor

et al. 2024

Front. Immunol.

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“…(60%, 15/25) [10]. The reason for the higher mortality rate in patients on ICU admission compared to patients without ICU treatment (14.8%, 21216/149084) [9] may be related to the increased severity of the disease.…”

Section: Discussionmentioning

confidence: 99%

High myoglobin level as an independent risk factor for death in patients with critical COVID-19 infection：A retrospective case-control study

Sun,

Zhang,

Zhang

et al. 2024

Preprint

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Aim This study aimed to discover risk factors for death in patients with critical COVID-19 infection in order to identify patients with a higher risk of death at an early stage. Methods We retrospectively analyzed the clinical data of patients with critical COVID-19 infection from April 2022 to June 2022. Data were collected from the electronic medical records. Propensity matching scores were used to reduce the effect of confounding factors, such as patient baseline variables. Independent risk factors affecting patient prognosis were assessed using univariate logistic regression and multivariate logistic regression analysis. Restricted cubic spline curves were used to assess the relationship between independent and dependent variables. Results The data of 137 patients with critical COVID-19 infection were collected. Of the 137 patients, 84 survived and 53 died. Among laboratory indicators, patients who died had higher proportions of abnormalities in RDW SD, procalcitonin, aspartate aminotransferase (AST), creatinine, potassium, cardiac troponin I, and myoglobin. Univariate and multivariate logistic regression analyses suggested that abnormal AST (OR = 3.26, P = 0.044), creatinine (OR = 4.49, P = 0.037), and myoglobin (OR = 9.88, P = 0.025) were independent risk factors for death. After correction for AST and creatinine, a linear relationship between myoglobin and risk of death in patients was found using restricted cubic splines. Conclusion High myoglobin level is an independent risk factor for death and is therefore a prognostic marker in patients with severe COVID-19 infection.

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“…[6] Previous studies have found that neutrophillymphocyte ratio (NLR), interleukins 6, C-reactive protein (CRP) and D-dimer were related to hospitalization rates, rates of severe illness, and mortality rates following COVID-19 infection. [7][8][9][10][11] Cancer patients with COVID-19 have been found to be at higher risk of hospitalization, requiring oxygen support, being admitted to intensive care units, and mortality rate. [12] However, few studies have assessed the role of CRP in cancer patients with COVID-19 infection.…”

Section: Introductionmentioning

confidence: 99%

Association between serum C-reactive protein (CRP) and Omicron variant COVID-19 pneumonia in cancer patients: A multicenter cross-sectional study at the end of 2022 in China

Che,

Zeng,

Hong

et al. 2024

Medicine

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Cancer patients with COVID-19 have a higher infection rate and mortality rate than non-cancer patients. However, there are few studies on the correlation between the serum C-reactive protein (CRP) and cancer patients with COVID-19. This study aims to investigate the association between serum CRP and the incidence of COVID-19 pneumonia in cancer patients at the end of 2022 in China. This cross-sectional study with a retrospective cohort between December 2022 and February 2023 assessed cancer patients complicated with COVID-19 infection in 2 Chinese institutions. Logistic regression analyses were used to compute Odds ratio (OR) and 95%CIs for the association between serum CRP and the incidence of COVID-19 pneumonia in cancer patients. A total of 213 cancer patients with COVID-19 were enrolled. Eighty-six patients (40.4%) developed COVID-19 pneumonia, among which 23 patients (10.8%) progressed to severe cases. Univariate Logistic regression showed that high CRP levels were found to be an unfavorable predictor of COVID-19 outcomes (OR = 17.9, 95%CI: 7.3, 43.6; P < .001). In the multivariate analysis, high CRP levels were associated with a higher incidence rate of COVID-19 pneumonia (OR = 9.8, 95%CI: 2.2, 43.8; P = .003). In the multivariate logistic regression model and smooth curve fitting, we found a correlation between CRP and COVID-19 pneumonia. The serum CRP was associated with the incidence of Omicron variant COVID- 19 pneumonia in cancer patients. Hence, cancer patients with high CRP level maybe need for timely computer tomography examination and more aggressive treatment.

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C-reactive protein isoforms as prognostic markers of COVID-19 severity

Cited by 19 publications

References 36 publications

C-reactive protein-complement factor H axis as a biomarker of activity in early and intermediate age-related macular degeneration

C-reactive protein-complement factor H axis as a biomarker of activity in early and intermediate age-related macular degeneration

High myoglobin level as an independent risk factor for death in patients with critical COVID-19 infection：A retrospective case-control study

Association between serum C-reactive protein (CRP) and Omicron variant COVID-19 pneumonia in cancer patients: A multicenter cross-sectional study at the end of 2022 in China

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