C-reactive protein levels and prevalence of chronic infections in subjects with hypoalphalipoproteinemia

Mostaza, José María; Camino, Nuria; Gerique, JA Gómez; Peña, Rocı́o; Baquero, Margarita; Lahoz, Carlos

doi:10.1016/j.metabol.2004.07.009

Cited by 13 publications

(9 citation statements)

References 31 publications

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“…For example, low HDL-C levels have been described in patients with acute infections and rheumatologic diseases, and cholesterol efflux to HDL particles is impaired in animal models of sepsis [25–27]. As with HIV infection, HDL changes in the context of other infections are, to some extend, a non-specific consequence of inflammation [28]. Consistent with this, we describe increases in HDL measures that were greatest for those with the most inflammation at baseline (reflected in hsCRP and IL-6 levels).…”

Section: Discussionmentioning

confidence: 99%

Inflammation predicts changes in high-density lipoprotein particles and apolipoprotein A1 following initiation of antiretroviral therapy

Baker

Neuhaus

Duprez

et al. 2011

Aids

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Background The effects of HIV infection and antiretroviral therapy (ART) on usual lipid levels have been reported. The effects of initiating versus deferring ART on high- and low-density lipoprotein particle concentrations (HDL-P and LDL-P) and apolipoprotein (Apo) levels are not well described. Methods In a subgroup of participants not taking ART at study entry who were randomized in the Strategies for Management of Antiretroviral Therapy (SMART) to immediately initiate ART (‘VS group’) or to defer it (‘DC group’), lipoprotein particle concentrations and ApoA1 and ApoB levels were measured at baseline and at 2 and 6 months following randomization. Results Compared to DC group (n=126), HDL-P and ApoA1 levels increased among VS participants (n=128) after starting ART. At 6 months, VS participants had 13% higher total HDL-P (p < 0.001) and 9% higher ApoA1 (p < 0.001). LDL-P, VLDL-P, and ApoB did not differ significantly between the VS and DC groups. Among VS participants, predictors of HDL-P and ApoA1 increases included baseline levels of hsCRP and IL-6, but not HIV RNA level, CD4 count or traditional CVD risk factors. The effect of starting ART on changes in HDL-P and ApoA1 was greater for those with higher versus lower baseline levels of IL-6 (p=0.001 and 0.08, respectively, for interaction) or hsCRP (p=0.01 and 0.04, respectively, for interaction). Conclusion HDL-P and ApoA1 increase following ART initiation, to a degree that depends on the degree of inflammation present at entry. These findings suggest that activation of inflammatory pathways contribute to HIV-associated changes in HDL.

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Section: Discussionmentioning

confidence: 99%

Inflammation predicts changes in high-density lipoprotein particles and apolipoprotein A1 following initiation of antiretroviral therapy

Baker

Neuhaus

Duprez

et al. 2011

Aids

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show abstract

“…A number of previous studies have demonstrated a significant relation between Helicobacter pylori and metabolic risk factors, atherosclerosis, and cardiovascular diseases [2][3][4][5][6][7][8][9][10] . Although, other studies could not confirm this association [11][12][13][14][15] . Thus, the interrelation between Helicobacter pylori infection and…”

Section: Introductionmentioning

confidence: 97%

Helicobacter Pylori Infection is a Significant Risk for Modified Lipid Profile in Japanese Male Subjects

Satoh

Saijo

Yoshioka

et al. 2010

JAT

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“…Some epidemiologic studies have reported a significant link between H. pylori infection and cardiovascular disease (CVD) risk factors [1–7], suggesting that chronic inflammation caused by H. pylori may promote atherosclerosis and CVD. The results of other studies, however, failed to confirm this connection [8–13]. Thus, the inter‐relation between H. pylori and atherosclerosis/CVD remains controversial.…”

mentioning

confidence: 99%

Helicobacter pylori Infection Significantly Increases Insulin Resistance in the Asymptomatic Japanese Population

et al. 2009

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C-reactive protein levels and prevalence of chronic infections in subjects with hypoalphalipoproteinemia

Cited by 13 publications

References 31 publications

Inflammation predicts changes in high-density lipoprotein particles and apolipoprotein A1 following initiation of antiretroviral therapy

Inflammation predicts changes in high-density lipoprotein particles and apolipoprotein A1 following initiation of antiretroviral therapy

Helicobacter Pylori Infection is a Significant Risk for Modified Lipid Profile in Japanese Male Subjects

Helicobacter pylori Infection Significantly Increases Insulin Resistance in the Asymptomatic Japanese Population

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