C-reactive protein levels in the early stage of COVID-19

Wang, L

doi:10.1016/j.medmal.2020.03.007

Cited by 596 publications

(586 citation statements)

References 18 publications

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“…Finally, the results show that elevated CRP of above 8 mg/dl, is associated with an increase in COVID-19 mortality rate. Hence, and in parallel with previous studies, elevated CRP, as an in ammatory biomarker, could indicate lung damage and therefore represents the severity of the respiratory tract involvement in patients with COVID-19 [31].…”

Section: Crpsupporting

confidence: 75%

Value of laboratory tests in COVID-19 hospitalized patients for clinical decision-makers: a predictive model, using data mining approach

Mousavi

Rezaei

Salamzadeh

et al. 2020

Preprint

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Purpose: Because of the rapid increase in confirmed cases of COVID-19, in particular those with severe or critical status, overwhelming of health systems is a worldwide concern. Therefore, identifying high-risk COVID-19 patients, can help service providers for priority setting and hospital resource allocation. Methods: 4542 adult patients with confirmed COVID-19 admitted in 15 hospitals in Tehran, Iran, from Feb 20 to April 18, 2020 were included in this retrospective cohort study with final outcomes of survived and died patients. Demographic features including age and sex, and laboratory data measured at admission were extracted and compared between recovered and died patients. Data analysis was performed applying SPSS modeler software using a logistic regression method.Results: Of 4542 hospitalized adult patients, 822 patients (18.09%) died during hospitalization, and 3720 (81.90%) recovered and discharged. Based on logistic regression model, older age, 40-49 (RR= 1.80, CI: 1.13-2.87), 50-59 (RR=2.63, CI: 1.71-4.02), 60-69 (RR= 4.40, CI: 2.92-6.63), 70-79 (RR=7.49, CI: 5.01-11.19), Above 80 (RR=13.85, CI: 9.23-2.77), ALT ≥ 55 IU/ (RR=2.20, CI: 1.69-2.86), AST ≥ 100 IU/L (RR=5.93, CI: 4.75-7.39), ALP ≥ 200 IU/L (RR=2.46, CI: 1.80-3.37), sodium < 135 mEq/l (RR=1.69, CI: 1.35-2.11) or more than 145 mEq/l (RR=7.24, CI: 5.07-10.33), potassium > 5.50 mEq/l (RR=7.53, CI: 4.15-13.64), and calcium < 8.50 mEq/l (RR=3.39, CI: 2.81-4.09), CPK between 307-600 IU/L (RR=2.73, CI: 2.12-3.53) and above 600 IU/L (RR=4.41, CI: 3.40-5.71) in men, and 192-400 IU/L (RR=2.73, CI: 2.12-3.53), and above 400 (RR=4.41, CI: 3.40-5.71) in women, CRP > 3 mg/l (RR=3.22, CI: 1.99-5.20), and creatinine > 1.5 mg/l (RR=6.37, CI: 5.30-7.66) were significantly associated with COVID-19 mortality. Conclusion: Our findings suggested less than one in five hospitalized patients with COVID-19 die mostly due to electrolyte disbalance, liver, and renal dysfunctions. Better supportive care is needed to improve outcomes for patients with COVID-19.

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Section: Crpsupporting

confidence: 75%

Value of laboratory tests in COVID-19 hospitalized patients for clinical decision-makers: a predictive model, using data mining approach

Mousavi

Rezaei

Salamzadeh

et al. 2020

Preprint

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“…Researcher from China assessed the usefulness of CRP levels in the early stage of COVID-19 and found that it positively correlated with lung lesions and could re ect disease severity [12]. Meta-analysis of reports from China have also detailed C-reactive along with D-dimers, coagulation times, and lactate dehydrogenase; with lower platelet and lymphocyte counts a common nding in " Cytokine Storm Syndrome " in hospitalized patients with COVID-19 [13].…”

Section: Discussionmentioning

confidence: 99%

Utility of routine haematological parameters and infectious biomarkers to assess the disease severity in COVID-19 positive patients, analysis and early trend from India

Singh¹,

Singh²,

Kelkar³

2020

Preprint

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Abstract Background and Objective- India has emerged as fifth worst hit nation by novel Corona virus pandemics in terms of total number of cases. Our literature on clinicopathological, hematopathological characterstics and trend is still miniscule. The study was conducted to assess utility of haematological parameters and infection biomarkers in identifying disease severity. Method- The test results for complete blood counts, Coagulation screen and inflammatory markers of covid 19 positive patients were recorded and analysed based on their admission to Intensive care units, High Dependency Units or Ward. Those parameters with significant differences between the groups werewere assessed by receiver operating curve and the best screening cut-off was selected. Results- 100 adults were analysed, area under the curve for total leukocyte count, Absolute neutrophil count, Neutrophil-to-Lymphocyte ratio was found >0.800, with p<0.05.The best cut off value obtained for TLC was 8100/cmm, with sensitivity and specificity of 91% and 62.5%; ANC – 6739/cmm, with 91.7% and 75% respectively; NLR - 6.9 with sensitivity and specificity 91.7% and 87.5% respectively. Haematological parameters of 33 paediatric patients studied separately and were well within normal physiological limits. Interpretation and conclusion- study suggests that in adults, using TLC, ANC and NLR, obtained from the basic preliminary workup may segregate patients requiring intensive care at the time of admission enabling risk stratification and guide intervention.

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“…It has been used as a diagnostic tool [15], but also as a marker of severity since chest CT score has been correlated with mortality [16]. To our knowledge, except one study that correlated CRP levels and the diameter of the largest lung lesion [17], relation between CRP and lung involvement severity on chest CT scan has not been previously reported. As we found that CRP values were signi cantly associated with the CT score and clinical severity, CRP measurements could be used as an alternative tool to chest CT for evaluating the severity of the pulmonary disease, particularly if chest CT is not feasible.…”

Section: Discussionmentioning

confidence: 99%

Level of CRP predicts need for respiratory support in hospitalized COVID-19 patients

Markowicz¹,

Donat²,

Glaude³

et al. 2020

Preprint

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PurposePredictors of disease severity in COVID-19 are essential to identify patients requiring hospitalization. Our aim was to determine the relationship of C-reactive protein (CRP) with the need for respiratory support.MethodsThis was a retrospective monocentric study of all patients hospitalized for confirmed COVID-19 pneumonia. CRP was measured on admission in the serum. Patients were classified using the Pneumonia Severity Index (PSI) and a 3-stage internal severity score (ISS) based upon respiratory parameters. Chest CT scans performed on admission were analysed following guidelines. Correlations of CRP levels with disease severity, radiological score, oxygen or mechanical ventilation requirement, and death were studied.Results61 patients were included from March 13th to April 8th, 2020. CRP levels were better related to the ISS compared to the PSI, being 18 (5-54), 130 (50-147) and 169 (97-241) mg/L respectively for the low, intermediate and high severity groups (p = 0.004 and p = 0.017). Analysis of the 51 available CT scans found a smaller correlation between CRP levels and radiological score (p < 0.05). The CRP levels were related to oxygen requirement (n = 50, p = 0.001), mechanical ventilation (n = 20, p = 0.004) and death (n = 10, p= 0.001).ConclusionCRP level on admission was a good marker of clinical and radiological severity in COVID-19 pneumonia, and could be used to identify patients needing hospitalization and intensive care.

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C-reactive protein levels in the early stage of COVID-19

Cited by 596 publications

References 18 publications

Value of laboratory tests in COVID-19 hospitalized patients for clinical decision-makers: a predictive model, using data mining approach

Value of laboratory tests in COVID-19 hospitalized patients for clinical decision-makers: a predictive model, using data mining approach

Utility of routine haematological parameters and infectious biomarkers to assess the disease severity in COVID-19 positive patients, analysis and early trend from India

Level of CRP predicts need for respiratory support in hospitalized COVID-19 patients

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