C-reactive protein: Ligands, receptors and role in inflammation

Marnell, Lorraine L.; Mold, Carolyn; Clos, Terry W. Du

doi:10.1016/j.clim.2005.08.004

Cited by 570 publications

(453 citation statements)

References 74 publications

Supporting

Mentioning

421

Contrasting

Unclassified

Order By: Relevance

“…C-reactive protein (CRP), an acute phase protein, is produced mainly by hepatocytes as a response to inflammation [12]. Thus, the measurement of circulating serum CRP is an important monitor of inflammatory disease in clinical routine [13].…”

Section: Introductionmentioning

confidence: 99%

Pre-operative serum C-reactive protein as independent prognostic factor for survival but not infection in patients with high-grade osteosarcoma

Funovics

Edelhauser

Funovics

et al. 2011

International Orthopaedics (SICOT)

View full text Add to dashboard Cite

Purpose The purpose of this study was to investigate (a) whether pre-operative serum CRP is a predictor of survival in patients with high-grade osteosarcoma, (b) whether postoperative infection is a predictor of survival in these patients and (c) whether CRP is a predictor of postoperative infection, and especially deep prosthetic infection. Methods In this retrospective single-centre study, preoperative serum CRP levels in 79 patients (37 females, 42 males; average age, 18 years; mean follow-up, 46 months) undergoing resection of an osteosarcoma were correlated with clinical data and survival. Results The mean pre-operative serum CRP level of all 79 patients was 0.53 mg/dl (SD, 1.27 mg/dl). Patients dying of their underlying disease had significantly higher CRP levels compared to patients surviving throughout the follow-up period (1.09 mg/dl ± 2.02 mg/dl versus 0.32 mg/dl ± 0.75 mg/dl, respectively; p=0.015). CRP levels were significantly correlated with survival (Pearson's correlation coefficient= −0.25; p =0.026) and histological subtype (Pearson's correlation coefficient=−0.42; p<0.001), but not with sex, age, histological response, tumour size or metastatic disease. In uni-and multivariate survival analysis, age, response to chemotherapy and serum CRP were associated with disease-specific survival. Patients with a CRP level over 1 mg/dl had a significantly lower diseasespecific five-year survival of 36.7% compared to 73.8% in patients with normal CRP values (p=0.020). Infection was not correlated with disease-specific survival. Pre-operative serum CRP levels were not correlated with post-operative infection or deep prosthetic infection. Conclusions Pre-operative serum CRP seems to be an independent predictor of survival in patients with highgrade osteosarcoma. Further studies are needed to confirm these results on a large-scale basis.

show abstract

Section: Introductionmentioning

confidence: 99%

Pre-operative serum C-reactive protein as independent prognostic factor for survival but not infection in patients with high-grade osteosarcoma

Funovics

Edelhauser

Funovics

et al. 2011

International Orthopaedics (SICOT)

View full text Add to dashboard Cite

show abstract

“…serum amyloid P component | CD89 | acute phase protein C -reactive protein (CRP), a member of the pentraxin family, is a major acute-phase protein in humans and is a clinical marker of infection (1). Interest in the biological activities of CRP has increased dramatically in recent years because of its association with inflammatory diseases such as atherosclerosis and autoimmune diseases such as systemic lupus erythematosus.…”

mentioning

confidence: 99%

“…Although the role of CRP in pathogen clearance through complement activation has been established (2), the participation of pentraxins in activating cellular immune functions is poorly understood because of a lack of knowledge of their cellular receptors. CRP and SAP have been shown to bind and activate Fcγ receptors (FcγR) on monocytes and macrophages (1,(3)(4)(5)(6). In addition, CRP suppressed immune complex-mediated nephrotoxic nephritis in a mouse model (7).…”

mentioning

confidence: 99%

Recognition and functional activation of the human IgA receptor (FcαRI) by C-reactive protein

Marjon

Marnell

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

View full text Add to dashboard Cite

C-reactive protein (CRP) is an important biomarker for inflammatory diseases. However, its role in inflammation beyond complement-mediated pathogen clearance remains poorly defined. We identified the major IgA receptor, FcαRI, as a ligand for pentraxins. CRP recognized FcαRI both in solution and on cells, and the pentraxin binding site on the receptor appears distinct from that recognized by IgA. Further competitive binding and mutational analysis showed that FcαRI bound to the effector face of CRP in a region overlapping with complement C1q and Fcγ receptor (FcγR) binding sites. CRP cross-linking of FcαRI resulted in extracellular signal-regulated kinase (ERK) phosphorylation, cytokine production, and degranulation in FcαRI-transfected RBL cells. In neutrophils, CRP induced FcαRI surface expression, phagocytosis, and TNF-α secretion. The ability of CRP to activate FcαRI defines a function for pentraxins in inflammatory responses involving neutrophils and macrophages. It also highlights the innate aspect of otherwise humoral immunity-associated antibody receptors.

show abstract

“…It was recently reported that a similar proportion of ET patients with monoclonal XCIPs patterns could be found in JAK2 mutated and non-mutated patients. 5,6 However, in those studies, only HUMARA assay was performed to assess clonality, a methylation-based test that is not completely reliable for patients' samples analysis because of possible abnormal DNA methylation in malignancies. 7 We studied a series of female ET patients in whom XCIPs had previously been analyzed by our group using both gene methylation and expression assays in all hematopoietic cell lineages 1,2 for the presence of mutant JAK2 and tested if the mutation correlated with monoclonal phenotype that would be expected if JAK2 mutation plays a role in disease development.…”

mentioning

confidence: 99%

Autoimmune hemolytic anemias and IgG antierythrocyte autoantibodies in Waldenström's macroglobulinemia: association with FcγRIIa polymorphism

et al. 2006

View full text Add to dashboard Cite

C-reactive protein: Ligands, receptors and role in inflammation

Cited by 570 publications

References 74 publications

Pre-operative serum C-reactive protein as independent prognostic factor for survival but not infection in patients with high-grade osteosarcoma

Pre-operative serum C-reactive protein as independent prognostic factor for survival but not infection in patients with high-grade osteosarcoma

Recognition and functional activation of the human IgA receptor (FcαRI) by C-reactive protein

Autoimmune hemolytic anemias and IgG antierythrocyte autoantibodies in Waldenström's macroglobulinemia: association with FcγRIIa polymorphism

Contact Info

Product

Resources

About