C-Reactive Protein: More than a Biomarker

Herwald, Heiko; Egesten, Arne

doi:10.1159/000519091

Cited by 13 publications

(10 citation statements)

References 11 publications

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“…Subcutaneous adipose tissue THADA-AS expression was positively correlated with insulin resistance, abdominal fat accumulation, serum triglyceride levels, but with higher levels of plasma Interleukin-1 receptor antagonist (IL-1Ra) and C-reactive protein (CRP). While IL-1Ra plays a protective role in inflammation 27 , CRP has been used as a biomarker of increased inflammation in acute injuries and chronic disease 28 . Expression of GIN1 was correlated with higher plasma adiponectin and lower plasma insulin levels.…”

Section: Resultsmentioning

confidence: 99%

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Predicting mechanisms of action at genetic loci associated with discordant effects on type 2 diabetes and abdominal fat accumulation

Aberra

Björkegren

et al. 2022

Preprint

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Obesity is a major risk factor for cardiovascular disease, stroke and type 2 diabetes (T2D). One risk factor that couples the adipose tissue accumulation characteristic of obesity to increased T2D risk is abdominal fat accumulation, measured by calculating the ratio of waist-to-hip circumference adjusted for the body-mass index (WHRadjBMI). Body fat distribution is estimated to have 40-80% heritability, which suggests a strong genetic component. Genetic loci associated with WHRadjBMI identified in genome-wide association studies (GWAS) are predicted to act through adipose tissues, but the molecular mechanisms regulating the accumulation of adipose tissue in various fat depots and their consequences for T2D risk are poorly understood. By integrating multi-omic data with colocalization analysis and Tissue of Action score analysis, we predicted colocalization of 79 genetic loci associated with both T2D adjusted for BMI (T2DadjBMI) and WHRadjBMI. Six of these loci were significantly associated with discordant effects on T2DadjBMI and WHRadjBMI, meaning that the alleles of the lead genetic variants in these loci that were protective for T2D were associated with increased abdominal obesity. Genes in these loci could explain the metabolically healthy obesity and lean insulin resistance (MHO/LIR) phenotype; therefore, we predicted functional genes and tissues of action at the discordant loci, and investigated how expression of these genes was linked to metabolic phenotypes. Through this rigorous consensus analysis, we provide evidence for the hypothesis that the genes encoding Thyroid Adenoma Associated Protein Antisense RNA (THADA-AS), Gypsy Retrotransposon Integrase 1 (GIN1), and Peptidylglycine Alpha-Amidating Monooxygenase (PAM) are involved in molecular mechanisms that uncouple abdominal fat accumulation from risk for T2D.

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Section: Resultsmentioning

confidence: 99%

“…While IL-1Ra plays a protective role in inflammation 27 , CRP has been used as a biomarker of increased inflammation in acute injuries and chronic disease 28 . Expression of GIN1 was correlated with higher plasma adiponectin and lower plasma insulin levels.…”

Section: Correlation Analysis Of Genetic Expression Reveals Physiolog...mentioning

confidence: 99%

Predicting mechanisms of action at genetic loci associated with discordant effects on type 2 diabetes and abdominal fat accumulation

Aberra

Björkegren

et al. 2022

Preprint

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“…CRP is a common serum marker of in ammatory status [9] , and the PHA may also re ect the in ammatory status of the body [10] . The results of this study showed that in the ESRD population, HD patients had the highest CRP and the lowest PHA, suggesting a severe in ammatory state in HD patients.…”

Section: Discussionmentioning

confidence: 99%

Comparison of body composition in different dialysis states of end-stage renal disease and analysis of influencing factors

Sun

et al. 2023

Preprint

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Objective:To compare the differences in body composition in end-stage renal disease patients. Methods:General data, biochemical data, and body composition indexes were collected to compare the differences in body composition indexes in ND, PD, and HD states. Spearman’s correlation and multiple linear stepwise regression analyses were performed to investigate the factors influencing the dependent variables. Results: (1) Skeletal muscle index and phase angle were higher in the PD group than in the HD group (p < 0.05); total body water was lower in the PD and HD groups than in the CKD5-ND group (p < 0.05). (2) In the CKD5-ND and PD groups, the influencing factors of PHA were age, albumin, and prealbumin. Conclusion: The patients with this central abdominal dialysis were better than those with HD in terms of nutrition and inflammation. PHA may be used to evaluate the nutritional status of patients with CKD5-ND and PD.

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“…CRP increased by 30% in infants with IDA, which we could not explain. CRP is an acute-phase protein used to assess inflammation from different etiologies 24 . ID impairs immune function and increases the risk of infections, especially in infants with IDA, exacerbating the inflammatory process and possibly explaining the association found in the study 25 .…”

Section: Discussionmentioning

confidence: 99%

Iron deficiency anemia in infants in Sousa (PB), Brazil: an association with nutritional status

Araújo

Faria

Sarni

2022

Rev. Assoc. Med. Bras.

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OBJECTIVE:The aim of this study was to describe the prevalence of anemia and iron deficiency anemia (IDA) in infants and verify the association of iron deficiency with nutritional status. METHODS: This cross-sectional and observational study included 104 infants aged between 7 and 9 months, assisted from August to September 2021 by the Family Health Strategy program in Sousa municipality (Paraíba, Brazil). Clinical and anthropometric data were collected, and a 24-h food recall questionnaire was applied using the DietPro software (version 5.0) in order to verify food consumption and assess iron intake. Variables associated with iron deficiency (p<0.05) were analyzed using multiple logistic regression. RESULTS: Anemia and IDA were observed in 40.4% and 19.2% of infants, respectively. Only one infant was taking prophylactic supplementation (ferrous sulfate). Infants with IDA presented reduced hemoglobin (p<0.001) and ferritin (p<0.001) and increased Z-scores of body mass index-forage (Z-BMI) (p=0.027), weight-for-height (p=0.007), and weight-for-age (p=0.032). All Z-scores were inversely correlated with ferritin (Z-BMI [rho: -0.37; p<0.001], weight-for-height [rho: -0.37; p<0.001], and weight-for-age [rho: -0.29; p=0.002]). Ferritin was also directly correlated with daily iron intake (rho: 0.22; p=0.018). Finally, multiple logistic regression showed a significant and direct association of iron deficiency with weight-forheight Z-score (odds ratio: 2.86; 95% confidence interval: 1.38-5.64; p=0.004). CONCLUSION: About 60% of infants presented anemia or IDA. Iron deficiency was associated with the weight-for-height Z-score, showing the vulnerability of infants during the introduction of complementary feeding.

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C-Reactive Protein: More than a Biomarker

Cited by 13 publications

References 11 publications

Predicting mechanisms of action at genetic loci associated with discordant effects on type 2 diabetes and abdominal fat accumulation

Predicting mechanisms of action at genetic loci associated with discordant effects on type 2 diabetes and abdominal fat accumulation

Comparison of body composition in different dialysis states of end-stage renal disease and analysis of influencing factors

Iron deficiency anemia in infants in Sousa (PB), Brazil: an association with nutritional status

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