C-reactive protein on postoperative day 3 as a predictor of infectious complications following gastric cancer resection

Abstract

Background Postoperative infectious complications (PICs) after gastric cancer resection remain a clinically relevant problem. Early detection of PICs, before critical illness develops, may be of considerable clinical benefit. The aims of this study were to investigate the predictive factors for PICs and to define the clinical parameters for detecting them early in patients with gastric cancer resection. Methods Clinical data for 417 consecutive patients undergoing elective gastrectomy for primary gastric cancer between 2009 and 2012 were retrospectively analyzed. Conclusions Elevated CRP levels on POD 3 will help physicians predict the postoperative course and facilitate decision-making regarding prompt, comprehensive clinical searches and therapeutic approaches for PICs.

Postoperative decrease of serum albumin predicts short-term complications in patients undergoing gastric cancer resection

“…Nevertheless, increasing evidence shows that postoperative CRP level, as a risk factor for postoperative inflammation, can be used to predict complications after gastrectomy[7,24]. For instance, Kim et al[16] found that the CRP level on POD 4 was one of the most reliable predictors for complications following gastric cancer resection, when compared to many systematic inflammatory markers (white blood cells, neutrophils, platelet counts and CRP on POD 1).…”

Change in serum albumin level predicts short‐term complications in patients with normal preoperative serum albumin after gastrectomy of gastric cancer

“…Post‐operative CRP was considered as a suitable post‐operative predictor for complications of curative (R0) gastrectomy in previous study . In this work, receiver operating characteristic curve was performed to compare the predictive accuracy of CRP on POD 3 and ΔALB for post‐operative complications.…”

“…Classical inflammatory markers such as CRP is demonstrated that is an important predictor for post‐operative complications after gastrectomy . Shishido et al .…”

Identifying Candidates for Early Discharge After Gastrectomy: “It’s Tough to Make Predictions, Especially About the Future”

“…[4][5][6][7][8][9] As a type of acute-phase protein with a short half-life (*19 h), CRP functions as an early defense against infection in innate immunity. Several groups have reported that high CRP levels on postoperative day (POD) 3 or 4 show superior diagnostic accuracy for the prediction of postoperative complications after gastrectomy.…”

“…Several groups have reported that high CRP levels on postoperative day (POD) 3 or 4 show superior diagnostic accuracy for the prediction of postoperative complications after gastrectomy. 4,8 Others have devised a CRP-based nomogram incorporating the CRP level on POD 3, patient comorbidities, Eastern Cooperative Oncology Group (ECOG) performance status, and operative time to predict a patient's risk for a major complication after laparoscopic gastrectomy. 9 What these studies (and many similar studies) share in common is the use of either a single laboratory value or some combination of laboratory and clinical variables designed to predict a complicated postoperative course.…”