C-reactive protein predicts complications in community-associated S. aureus bacteraemia: a cohort study

Botheras, Carly L; Bowe, Steven J.; Cowan, Raquel; Athan, Eugene

doi:10.1186/s12879-021-05962-7

Cited by 5 publications

(3 citation statements)

References 62 publications

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“…The longer time until diagnosis in community compared to nosocomial infection and the delay in the start of treatment might allow for hematogenous seeding. As in our study, several studies have reported the association between elevated CRP levels and complicated SAB, deep-seated infections and even higher mortality 9 – 12 . Higher CRP values may indicate a more aggressive and extensive infection.…”

Section: Discussionsupporting

confidence: 84%

Predictors of infectious foci on FDG PET/CT in Staphylococcus aureus bacteremia

Ghanem-Zoubi,

Abu-Elhija,

Kagna

et al. 2023

Sci Rep

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We looked for predicting factors for the detection of infectious foci on 18F-fluorodeoxyglucose-positron emission tomography in combination with computed tomography (FDG PET/CT) among patients with Staphylococcus aureus bacteremia (SAB) who participated in an interventional study that was conducted at Rambam Health Care Campus, between July 1, 2015 and February 1, 2019. The primary outcome was an infectious focus detected by FDG PET/CT. Independent predictors for detection of focal infection were identified using univariate followed by a logistic regression multivariate analysis. We included 149 patients with 151 separate episodes of SAB who underwent FDG-PET/CT. Focal infections were detected in 107 patients (70.8%). Independent predictors for focal infection detection were community acquisition of bacteremia with odds ratio (OR) 3.03 [95% confidence interval (CI) 1.04–8.77], p-0.042 and C reactive protein (CRP) with OR 1.09 [95% CI 1.04–1.14], p < 0.001. Primary bacteremia was inversely associated with focal infection detection with OR 0.27 [0.10–0.69], p = 0.007, as were the pre-scan blood glucose levels OR 0.9 [0.98–0.99], p-0.004. The latter stayed significant in the subgroup of patients with diabetes mellitus. To conclude, patients with community-acquired bacteremia or high CRP levels should be carefully investigated for focal infection. Patients who present with primary bacteremia seem to be at low risk for focal infection.

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Section: Discussionsupporting

confidence: 84%

Predictors of infectious foci on FDG PET/CT in Staphylococcus aureus bacteremia

Ghanem-Zoubi,

Abu-Elhija,

Kagna

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

“…The longer time until diagnosis in community compared to nosocomial infection and the delay in the start of treatment might allow for hematogenous seeding. As in our study, several studies have reported the association between elevated CRP levels and complicated SAB, deep-seated infections and even higher mortality [9][10][11][12]. Higher CRP values may indicate a more aggressive and extensive infection.…”

Section: Discussionsupporting

confidence: 77%

Predictors of infectious foci on FDG PET/CT in Staphylococcus aureus bacteremia

Ghanem-Zoubi

Abu-Elhija

Kagna

et al. 2022

Preprint

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Purpose: To identify risk factors for detection of infectious foci on 18F-fluorodeoxyglucose-positron emission tomography in combination with computed tomography(FDG PET/CT) among patients with Staphylococcus aureus bacteremia (SAB). Methods: Cohort study of patients with SAB who underwent FDG PET/CT as part of an interventional study that was conducted at Rambam Health Care Campus, between July 1, 2015 to February 1, 2019. The primary outcome was an infectious focus detected by FDG PET/CT. Independent risk factors for detection of focal infection were identified using univariate followed by a logistic regression multivariate analysis. Results: We included 149 patients with 151 separate episodes of SAB who underwent FDG-PET/CT. Focal infections were detected in 107 patients (70.8%). Independent risk factors for focal infection detection were community acquisition of bacteremia with odds ratio (OR) 3.03 [95% confidence interval (CI) 1.04-8.77], p-0.042 and C reactive protein (CRP) with OR 1.09 [ 95% CI 1.04-1.14], p<0.001. Primary bacteremia was inversely associated with focal infection detection with OR 0.27 [0.10-0.69], p=0.007, as were the pre-scan blood glucose levels OR 0.9 [0.98-0.99], p-0.004. The latter stayed significant in the subgroup of patients with diabetes mellitus. Conclusion: Patients with community-acquired bacteremia or high CRP levels should be carefully investigated for focal infection. Patients who present with primary bacteremia seems to be at low risk for focal infection. Further studies should evaluate whether high glucose levels may result in false-negative infectious findings on FDG PET/CT.

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“…A similar result was also described by Lesen et al [28], showing that sustained bacteremia was significantly related to metastatic infection, while the CRP level of the patients was usually higher than 100 mg/L. From the cohort study, Botheras et al concluded that a CRP concentration of more than 161 mg/L on the day of admission was significantly associated with complications in community-associated S. aureus bacteremia [29]. The analytical results of our study revealed that a CRP level over 130 mg/L was significantly related with coexisting infections of infectious spondylitis and septic arthritis.…”

Section: Discussionsupporting

confidence: 72%

Risk Factors of Coexisting Septic Spondylitis and Arthritis: A Case-Control Study in a Tertiary Referral Hospital

Wang

Lai

Liu

et al. 2021

JCM

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Introduction: In patients under immunosuppression or severe sepsis, it is sometimes manifested as coexisting septic arthritis and spondylitis. The aim of this study is to evaluate and investigate the risk factors of infectious spondylitis associated with septic arthritis. Methods: The study retrospectively reviewed the patients diagnosed with infectious spondylitis between January 2010 and September 2018 for risk factors of coexisting major joint septic arthritis. Results: A total of 10 patients with infectious spondylitis and coexisting septic arthritis comprised the study group. Fifty matched patients with solely infectious spondylitis were selected as the control group. Major risk factors include preoperative C-reactive protein (p = 0.001), hypoalbuminemia (p = 0.011), history of total joint replacement (p < 0.001), duration of preoperative antibiotics treatment (p = 0.038) and psoas muscle abscess (p < 0.001). Conclusion: Infectious spondylitis and septic arthritis are thought of as medical emergencies due to their high mortality and morbidity. Our study evaluated 5 risk factors as significant major findings: hypoalbuminemia (<3.4 g/dL), higher preoperative CRP (>130 mg/L), psoas muscle abscess, longer preoperative antibiotics treatment (>8 days) and history of total joint replacement. Clinicians should pay attention to the patients with those five factors to detect the coexisting infections as early as possible.

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C-reactive protein predicts complications in community-associated S. aureus bacteraemia: a cohort study

Cited by 5 publications

References 62 publications

Predictors of infectious foci on FDG PET/CT in Staphylococcus aureus bacteremia

Predictors of infectious foci on FDG PET/CT in Staphylococcus aureus bacteremia

Predictors of infectious foci on FDG PET/CT in Staphylococcus aureus bacteremia

Risk Factors of Coexisting Septic Spondylitis and Arthritis: A Case-Control Study in a Tertiary Referral Hospital

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