C-reactive protein to albumin ratio, albumin to globulin ratio and platelet to lymphocyte ratio in patients with spondyloarthritis

Abstract

Aim:The C-reactive protein (CRP) to albumin ratio (CAR) has been reported as a novel inflammatory marker to assess inflammation. Serum globulin increases in inflammation. In this study, it was aimed to evaluate relation between CAR, albumin to globülin ratio (AGR), platelet to lymphocyte ratio (PLR) and disease activity in patients with axial spondyloarthritis (AxSpA).Method: Seventy-five patients with axial SpA and seventy-five healthy controls were evaluated retrospectively. CRP, albumin, globulin, leukocyte, lymphocyte, and platelet from the patients and controls were recorded. CAR, AGR and PLR were calculated. Disease activity was evaluated by the BASDAI and ASDAS. Results:The mean age was 38.2±10.39 years in patients with AxSpA and 35.45±8.96 years in controls. The CAR was 0.153±0.2 in AxSpA patients and 0.03±0.02 in controls (p<0.05). The CAR was 0.0972±0.16 in patients who had low disease activity and 0.213±0.275 in patients with high disease activity. The patients with high disease activity had higher CAR than patients with low disease activity (p<0.05). There was a statistically significant positive correlation between CAR and BASDAI and ASDAS respectively (rho 327, p<0.05, rho 0.523, p<0.05). The AGR was lower in AxSpA patients (p<0.05). There was a negative correlation between AGR and BASDAI but it was not significant (rho -0.044, p>0.05). There was significant correlation between PLR and BASDAI and ASDAS (rho 236, p<0.05 and rho 314, p<0.05 respectively). Conclusion:The CAR and PLR are an important markers for evaluating disease activity in patients with AxSpA. AGR may be a promising marker for assessing disease activity in AxSpA. ÖzetAmaç: C-reaktif protein (CRP) albumin oranı (CAO), inflamasyonu değerlendirmek için yeni bir inflamatuar belirteç olarak belirtilmiştir. Serum globulini inflamasyonda artar. Bu çalışmada aksiyal spondiloartritli (AxSpA) hastalarda hastalık aktivitesini ile (CAO), albumin globulin oranı (AGO) ve platelet lenfosit oranı (PLO) arasındaki ilişkiyi incelemek amaçlandı.Yöntem: Yetmiş beş aksiyel SpA'lı hasta ve yetmiş beş sağlıklı kontrol retrospektif olarak değerlendirildi. Hasta ve kontrollerin CRP, albumin, globulin, lökosit, lenfosit, nötrofil ve platelet değerleri kaydedildi. CAO, AGO ve PLO hesaplandı. Hastalık aktivitesi BASDAI ve ASDAS ile değerlendirildi.Bulgular: Ortalama yaş AxSpA hastalarında 38.2±10.39 yıl ve kontrollerde 35.45±8.96 yıl idi. CAO AxSpA hastalarında 0.153±0.2 ve kontrollerde 0.03±0.02 idi (p<0.05). CAO düşük hastalık aktiviteli hastalarda 0.0972±0.16, yüksek hastalık aktiviteli hastalarda 0.213±0.275 idi. Yüksek hastalık aktivitesi olan hastalar, düşük hastalık aktivitesi olan hastalardan daha yüksek CAO'ya sahipti (p<0.05). Sırasıyla CAO ile ve BASDAI ve ASDAS arasında istatistiksel olarak anlamlı pozitif korelasyon vardı (rho 327, p<0.05 ve rho 0.523, p<0.05). AxSpA hastalarında AGO daha düşüktü (p<0.05). AGO ile BASDAI arasında negatif korelasyon vardı ancak anlamlı değildi (rho -0.044, p>0.05). PLO ile BASDAI ve ASDAS arasında anlamlı bir ilişki...