C‐reactive protein trajectories and the risk of all cancer types: A prospective cohort study

Abstract

A single CRP measurement is insufficient to examine the association of long-term patterns of CRP concentration with cancer risk. We prospectively examined the relationship between CRP trajectory patterns and new-onset cancers among 52 276 participants. Latent mixture modeling was used to identify CRP trajectories. Cox proportional hazards regression models were used to evaluate the association between CRP trajectory patterns and the risk of overall and specific-site cancer. Four CRP trajectories patterns were identified: low-stable pattern (n = 43 258), moderateincreasing pattern (n = 2591), increasing-decreasing pattern (n = 2068) and elevated-decreasing pattern (n = 4359). Relative to the low-stable pattern, the moderate-increasing trajectory pattern was associated with an elevated risk of overall, lung, breast, leukemia, bladder, stomach, colorectal, liver, gallbladder or extrahepatic bile duct cancer and leukemia. Participants in the increasing-decreasing trajectory pattern were associated with an elevated risk of overall, lung, breast, bladder, pancreatic and liver cancer. The increasing-decreasing trajectory pattern was also associated with decreased risk of colorectal cancer in the multivariate analyses. Elevated-decreasing trajectory pattern was associated with increased risk of leukemia and decreased risk of esophageal and colorectal cancer. CRP trajectories play an important role in the occurrence of cancers, especially in the lung, breast, bladder, stomach, colorectal, liver, gallbladder and extrahepatic bile duct cancer and leukemia.

Insulin resistance and inflammation mediate the association of abdominal obesity with colorectal cancer risk

“…As previously stated ( 17 ), this study was based on the Kailuan Study, a community-based ongoing cohort study performed in Tangshan city. The current study investigated the risk factors for chronic diseases such as cancer.…”

“…The fasting triglyceride-glucose (TyG) index is a simple and cost-effective way to detect IR ( 14 ) compared to the gold standard hyperinsulinemic-euglycemic glucose clamp approach ( 15 ). High-sensitivity C-reactive protein (hs-CRP), also known as CRP assessed by high-sensitivity assays, is a typical protein produced in response to inflammation, infection, and tissue damage that has been linked to chronic disorders such as cardiovascular disease (CVD) and cancer ( 16 , 17 ). Based on the evidence above, we assume that the close association of abdominal obesity rather than general obesity with CRC risk might be mediated by IR and inflammation, which, to our knowledge, has never been systematically explored in large-scale prospective studies.…”

Higher circulating vitamin B12 is associated with lower levels of inflammatory markers in individuals at high cardiovascular risk and in naturally aged mice

“…Two meta‐analyses have confirmed that CRP is linked to a higher risk of incident cardiovascular events and can also predict future cardiovascular and all‐cause mortality in individuals with type‐2 diabetes 52,53 . CRP is also a potential biomarker for overall cancer because it plays a role in the occurrence of various types of cancer 54,55 …”

Immune Cell and Biochemical Biomarkers in Advanced Laryngeal Cancer

“…There have been numerous studies implicating CRP as a possible prognostic factor in solid tumors. 12,[34][35][36][37][38] CRP is a non-specific marker of acute phase inflammatory response. It is synthesized primarily in liver hepatocytes and stimulated by pro-inflammatory cytokines (IL-6, IL-1, and tumor necrosis alpha).…”