C-Reactive Protein versus Erythrocyte Sedimentation Rate: Implications Among Patients with No Known Inflammatory Conditions

Alende-Castro, Vanesa; Alonso-Sampedro, Manuela; Fernández-Merino, Carmen; Sánchez-Castro, Juan; Sopeña, B.; Gudé, Francisco; González‐Quintela, Arturo

doi:10.3122/jabfm.2021.05.210072

Cited by 15 publications

(11 citation statements)

References 47 publications

(86 reference statements)

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“…Some studies have suggested a relationship between abnormalities of the circadian BP profile and ESR, although further evidence is needed. [ 22 , 41 , 45 ].…”

Section: Discussionmentioning

confidence: 99%

“…Beta-2-microglobulin levels were measured by nephelometry employing a Dimension Vista® system (Siemens Healthcare Diagnostics Inc., Tarrytown, NY, USA) and concentrations were expressed in mg/dL. The gamma band mainly includes the immunoglobulins whose quantitative and qualitative evaluation allows the characterization of the immuno-inflammatory response [ 21 , 22 , 23 , 24 ].…”

Section: Methodsmentioning

confidence: 99%

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Implications of Inflammatory and Oxidative Stress Markers in the Attenuation of Nocturnal Blood Pressure Dipping

Hermida‐Ameijeiras

Vazquez-Agra

Cruces-Sande

et al. 2023

JCM

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To date, no model has jointly encompassed clinical, inflammatory, and redox markers with the risk of a non-dipper blood pressure (BP) profile. We aimed to evaluate the correlation between these features and the main twenty-four-hour ambulatory blood pressure monitoring (24-h ABPM) indices, as well as to establish a multivariate model including inflammatory, redox, and clinical markers for the prediction of a non-dipper BP profile. This was an observational study that included hypertensive patients older than 18 years. We enrolled 247 hypertensive patients (56% women) with a median age of 56 years. The results showed that higher levels of fibrinogen, tissue polypeptide-specific antigen, beta-2-microglobulin, thiobarbituric acid reactive substances, and copper/zinc ratio were associated with a higher risk of a non-dipper BP profile. Nocturnal systolic BP dipping showed a negative correlation with beta-globulin, beta-2-microglobulin, and gamma-globulin levels, whereas nocturnal diastolic BP dipping was positively correlated with alpha-2-globulin levels, and negatively correlated with gamma-globulin and copper levels. We found a correlation between nocturnal pulse pressure and beta-2-microglobulin and vitamin E levels, whereas the day-to-night pulse pressure gradient was correlated with zinc levels. Twenty-four-hour ABPM indices could exhibit singular inflammatory and redox patterns with implications that are still poorly understood. Some inflammatory and redox markers could be associated with the risk of a non-dipper BP profile.

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“…Some studies have suggested a relationship between abnormalities of the circadian BP profile and ESR, although further evidence is needed. [ 22 , 41 , 45 ].…”

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Implications of Inflammatory and Oxidative Stress Markers in the Attenuation of Nocturnal Blood Pressure Dipping

Hermida‐Ameijeiras

Vazquez-Agra

Cruces-Sande

et al. 2023

JCM

Self Cite

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“…A study in Spain examined ESR and CRP values in participants in a volunteer group of the general adult population without known inflammatory disease; 74.9% were found to have normal values, and the incompatibility between these two values was examined. While the incompatible model with high ESR and normal CRP was associated with older age, the model with high CRP and normal ESR was associated with higher body mass index [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Contribution of Erythrocyte Sedimentation Rate to Predict Disease Severity and Outcome in COVID-19 Patients

Kurt

Yıldırım

2022

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Aim. The use of erythrocyte sedimentation rate (ESR) in coronavirus disease 2019 (COVID-19) to determine disease severity and prognosis is limited. This study aimed to interrogate the diagnostic and prognostic role of ESR compared to other acute-phase reactants. Method. This retrospective cross-sectional study included 493 confirmed and hospitalized adult COVID-19 patients. Pneumonia, radiological severity, oxygen, intensive care requirements, mortality, ESR, and other acute-phase reactant values were recorded. Logistic regression and ROC analysis identified the effect of ESR on mortality and the sensitivity and specificity of the optimal cutoff values of ESR for the prediction of pneumonia, intensive care needs, and mortality and compared these with values for CRP. Results. Of patients, 346 (70.2%) had pneumonia, 98 (19.9%) required intensive care, 183 (37.1%) required oxygen support, and 62 (12.6%) died. ESR data were obtained for 278 patients. Among patients, 80.2% had ESR above 20 mm/h, with a median value of 53 (interquartile range: 49). ESR was higher among those with pneumonia ( p < 0.001 ), requiring oxygen ( p < 0.001 ), and requiring intensive care ( p = 0.003 ) compared to those without these, and in exitus patients ( p = 0.043 ) compared to survivors. Logistic regression analysis identified that ESR did not impact mortality. ROC analysis found the AUC, cutoff, sensitivity, and specificity results of ESR for pneumonia were 0.827, 37 mm/h, 77%, and 78%; for intensive care were 0.625, 50 mm/h, 74%, and 52; and for mortality were 0.606, 51 mm/h, 71%, and 49%, respectively. However, ROC analysis values for CRP were superior to ESR for all these categories. Conclusion. ESR increased in COVID-19 patients in the presence of pneumonia and severe disease; however, it was not prognostic. Sensitivity and specificity values for pneumonia, intensive care requirements, and mortality were lower than those for CRP.

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“…C-reactive protein (CRP) is an inflammatory protein found in the liver 1) . CRP levels rise swiftly in reaction to trauma, inflammation, and infection and fall quickly when the condition is resolved 2) .…”

Section: Introductionmentioning

confidence: 99%

Impact of Olive Oil Constituents on C-reactive Protein: <i>In silico</i> Evidence

et al. 2022

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or inhibitory effects, which aid in developing new and efficient therapeutics as lead molecules. VS exposes vast libraries of commercially available drug-like compounds that have been computationally tested against known structural targets and those projected to bind properly in experiments 7,8) .At numerous stages of drug development, pharmaceutical companies have made significant advancements in computer-aided drug design, including identifying new hits, enhancing molecule binding affinity in hit-to-lead, and lead optimization 9) . In addition, in silico approaches are frequently used in current drug design to assist in the knowledge of drug-receptor interactions. By exposing the mechanism of drug-receptor interactions, computational methodologies have been devised in the literature to Abstract: Pain is a sensation a humans sense as a protective mechanism against physical injury. This sensation is closely related to inflammation. It ranges from mild to highly obnoxious. It is well-known that the levels of the inflammatory biomarker, C-reactive protein (CRP), increase manifold in acute inflammation and pain. Olive oil, known to have many phytochemicals, has been traditionally used to alleviate pain. Amongst major phenolic compounds in olive oil are oleuropein (OLE), hydroxytyrosol (HT), tyrosol, and oleocanthal. Whether the analgesic and anti-inflammatory properties in olive oil are due to any specific interections is not known. Therefore, this study aimed to elucidate the possible anti-inflammatory and anti-nociceptive properties in those major phenolic compounds by using molecular docking software MOE 2015, comparing the energy value and binding site of phenolic compounds to that of well-known synthetic non-steroidal anti-inflammatory drugs (NSAIDs) and phosphocholine. The docking experiment showed that all compounds could directly interact with CRP. Oleuropein had the most potent interaction with CRP (-7.7580), followed by indomethacin (-6.0775), oleocanthal (-5.5734), ibuprofen (-5.3857), phosphocholine (-4.3876), HT (-4.2782), and tyrosol (-4.2329). Interestingly, the present study found other phytochemicals in olive oil that can be exploited as potential, safe, and cost-effective lead compound(s) for analgesic and anti-inflammatory activity, as supported by its molecular docking data.

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C-Reactive Protein versus Erythrocyte Sedimentation Rate: Implications Among Patients with No Known Inflammatory Conditions

Cited by 15 publications

References 47 publications

Implications of Inflammatory and Oxidative Stress Markers in the Attenuation of Nocturnal Blood Pressure Dipping

Implications of Inflammatory and Oxidative Stress Markers in the Attenuation of Nocturnal Blood Pressure Dipping

Contribution of Erythrocyte Sedimentation Rate to Predict Disease Severity and Outcome in COVID-19 Patients

Impact of Olive Oil Constituents on C-reactive Protein: <i>In silico</i> Evidence

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