C-reactive protein with sequential organ failure assessment score: Valuable parameters in managing acute pancreatitis

Bhatia, Mohit; Nirhale, Daksha S; Athavale, Virender S; Calcuttawala, Murtuza; Kale, Anirudha; Sankhe, Manashree

doi:10.4103/1119-0388.140423

Cited by 2 publications

(4 citation statements)

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“…[22] Bhatia et al found that patients with lower CRP levels at baseline had a milder course of AP and fewer associated complications. [23] Many studies have concluded that the clinical utility of CRP in the early stages of AP is limited and that the use of CRP alone potentially fails to detect severe cases of AP earlier. [24,25] RDW, which is a calculable measure of variability in erythrocyte volume, is an easy, cheap, and routinely used parameter as part of the complete blood count test.…”

Section: Discussionmentioning

confidence: 99%

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A comparison of scoring systems and biomarkers to predict the severity of acute pancreatitis in patients referring to the emergency clinic

Vahapoğlu,

Çalik

2024

Medicine

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To investigate scoring systems and biomarkers for determining the severity and prognosis of acute pancreatitis (AP). Between January and July 2023, 100 patients with AP diagnosed and treated in the emergency department were included. AP was divided into 2 groups according to severity: mild AP and moderately severe AP (MSAP-SAP), according to the revised Atlanta Classification in 2012. Demographic characteristics, severity, intensive care unit (ICU) admission, white blood cell count (WBC), hematocrit, red cell distribution width from whole blood taken at admission and 48 hours later, C-reactive protein (CRP) and biochemistry values, Bedside Index for Severity in Acute Pancreatitis (BISAP), Pancreatitis Activity Scoring System (PASS), and harmless AP score scores were recorded retrospectively. Our variables, which were found to be significant in multiple logistic regression results, were found to increase MSAP-SAP expectation by 4.36-, 7.85-, 6.63 and 5.80 times in the presence of CRP > 47.10, WBC > 13.10, PASS > 0, and necrotizing computed tomography findings, respectively. It was detected that the risk factor which was found significant as a single variable affecting the ICU admission increased the risk of ICU requirement by 28.88 when PASS > 0, by 3.96 when BISAP > 1, and it increased the Atlanta score by 9.93-fold. We found that WBC and CRP values at the time of hospital admission and WBC, CRP, and red cell distribution width values after 48 had the highest accuracy in determining AP disease severity. BISAP, which was found to be significant in determining MSAP-SAP expectations, lost its significance in multiple logistic regression results, and PASS was found to be effective. The PASS is an important score in the clinical evaluation of patients with AP and in determining the need for ICU hospitalization.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A comparison of scoring systems and biomarkers to predict the severity of acute pancreatitis in patients referring to the emergency clinic

Vahapoğlu,

Çalik

2024

Medicine

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“…A CRP value > 15 mg/dL after 48 h was characterized as a prognostic factor in the Santorini consensus conference (1999), World Gastroenterology Congress Guideline (2002), United Kingdom Guideline (2005), and Japanese criteria [23]. In addition, Arvanitakis et al [24] stated that there was a significant correlation between MR imaging performed within the first hours and the CRP level at 48 h. Although some studies have stated that the baseline CRP level has a predictive value for determining the severity of AP [25, 26], its accuracy is rather poor [1, 9]. The study conducted by Bhatia et al [25] demonstrated that AP followed a milder course in patients with low baseline CRP values, with less accompanying complications.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, Arvanitakis et al [24] stated that there was a significant correlation between MR imaging performed within the first hours and the CRP level at 48 h. Although some studies have stated that the baseline CRP level has a predictive value for determining the severity of AP [25, 26], its accuracy is rather poor [1, 9]. The study conducted by Bhatia et al [25] demonstrated that AP followed a milder course in patients with low baseline CRP values, with less accompanying complications. In our study, we found that baseline CRP was not satisfactory for predicting very mild pancreatitis.…”

Section: Discussionmentioning

confidence: 99%

Prediction of Self-Limited Acute Pancreatitis Cases at Admission to Emergency Unit

Kayar

Şentürk

Tozlu

et al. 2018

GE Port J Gastroenterol

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Background: While acute pancreatitis (AP) resolves spontaneously with supportive treatment in most patients, it may be life-threatening. Predicting the disease severity at onset dictates the management strategy. We aimed to define the patients with mild pancreatitis who may be considered for outpatient management with significant cost-savings. Materials and Methods: This prospective observational study included 180 patients with mild AP according to the harmless acute pancreatitis score (HAPS) and Imrie score. The relationships of biochemical parameters with the changes in the Balthazar score and clinical course were examined. Results: The study included 180 patients (111 females, 69 males; mean age: 53.9 ± 17.2 years; range: 17–92 years). The etiology was biliary in 118 (65%) patients and remained undetermined in 38 (21.1%) patients. Computed tomography (CT) performed within the first 12 h revealed mild and moderate AP in 159 (88.3%) and 21 (11.7%) patients, respectively. CT repeated at 72 h revealed mild, moderate, and severe AP in 155 (86.1%), 24 (13.3%), and 1 (0.6%) patients, respectively. Comparisons between stages A + B + C and D + E showed significant differences in the amylase levels on day 1 and 3, and in C-reactive protein on day 3. Also, in stage D and E disease, narcotic analgesic intake, oral intake onset time, and pain were significantly higher. Conclusion: There were no significant changes in the CT findings of patients with mild AP at 12 and 72 h. Most patients (n = 179; 99.4%) recovered uneventfully. Patients with mild pancreatitis according to the HAPS and Imrie scores can be considered for outpatient management. The recovery is longer in stage D and E disease.

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C-reactive protein with sequential organ failure assessment score: Valuable parameters in managing acute pancreatitis

Cited by 2 publications

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A comparison of scoring systems and biomarkers to predict the severity of acute pancreatitis in patients referring to the emergency clinic

A comparison of scoring systems and biomarkers to predict the severity of acute pancreatitis in patients referring to the emergency clinic

Prediction of Self-Limited Acute Pancreatitis Cases at Admission to Emergency Unit

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