C-terminal calcitonin gene-related peptide fragments and vasopressin but not somatostatin-28 induce miosis in monkeys

Almegård, Birgitta; Bill, Anders

doi:10.1016/0014-2999(93)90617-q

Cited by 7 publications

(3 citation statements)

References 15 publications

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“…Previous studies report that the pupil generally constricts after cataract surgery, 22 probably because of the traumatic release of miotic neuropeptides. [23][24][25] In our study, pupil diameter was approximately 0.5 mm smaller immediately after surgery.…”

Section: Discussionmentioning

confidence: 94%

Pupil size before and after phacoemulsification in nondiabetic and diabetic patients

Hayashi

2004

Journal of Cataract and Refractive Surgery

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Section: Discussionmentioning

confidence: 94%

Pupil size before and after phacoemulsification in nondiabetic and diabetic patients

Hayashi

2004

Journal of Cataract and Refractive Surgery

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“…Somatostatin also inhibits forskolinstimulated cAMP production in a preparation of isolated ciliary processes (Bausher and Horio, 1990) or isolated iris and ciliary body (Wax and Barrett, 1993). However, somatostatin-2 8 applied into the anterior chamber caused no change in pupil diameter (Almegard and Bill, 1993).…”

Section: Somatostatinmentioning

confidence: 99%

Innervation of the Uvea by Galanin and Somatostatin Immunoreactive Axons in Macaques and Baboons

Firth

Kaufman

Jean

et al. 2002

Experimental Eye Research

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The neuropeptide galanin has not been localized previously in the primate uvea, and the neuropeptide somatostatin has not been localized in the uvea of any mammal. Here, the distribution of galanin-like and somatostatin-like immunoreactive axons in the iris, ciliary body and choroid of macaques and baboons using double and triple immunofluorescence labeling techniques and confocal microscopy was reported. In the ciliary body, galanin-like immunoreactive axons innervated blood vessels and the ciliary processes, particularly at their bases. In the iris, the majority of these axons was associated with the loose connective tissue in the stroma. Somatostatin-like immunoreactive axons were found in many of the same areas of the uvea supplied by cholinergic nerves. In the ciliary body, there were labelled axons within the ciliary processes and ciliary muscle. They were also found alongside blood vessels in the ciliary stroma. In the iris, somatostatin-like immunoreactive axons were abundant in the sphincter muscle and less so in the dilator muscle. A unilateral sympathectomy had no effect on the distribution of somatostatin-like or galanin-like immunoreactive axons, and these axons did not contain the sympathetic marker tyrosine hydroxylase. They did not contain the parasympathetic marker choline acetyltransferase, either. The galanin-like immunoreactive axons contained other neuropeptides found in sensory nerves, including calcitonin gene-related peptide, substance P and cholecystokinin. Somatostatin-like immunoreactive axons did not contain any of these sensory neuropeptides or galanin-like immunoreactivity, and they were neither labelled with an antibody to 200 kDa neurofilament protein, nor did they bind isolectin-IB 4 . Nevertheless, they are likely to be of sensory origin because somatostatin-like immunoreactive perikarya have previously been localized in the trigeminal ganglion of primates. Taken together, these findings indicate galanin and somatostatin are present in two different subsets of sensory axons in primate uvea.

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“…However, the miotic effect of PGs after surgical trauma in the human eye is controversial (Camras & Miranda 1989). Recently, several neuropeptides such as substance P (Bito et al 1982), cholecystokinin (CCK) (Bill et al 1990;Almegird et al 1992) and calcitonin gene-related peptide (Almegird & Bill 1993) have been found to influence the pupillary response. The iridial concentration of neuropeptides (substance P and calcitonin gene-related peptide) is significantly higher in diabetics than in controls (Marfurt et al 1995).…”

Section: Discussionmentioning

confidence: 99%

Cataract surgery and pupil size in patients with diabetes mellitus

Żaczek

Zetterström

1997

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: Constriction of the pupil during phacoemulsification and intraocular lens (IOL) implantation in patients with diabetes mellitus was studied. Metha%: Before surgery a combination of 0.75% cyclopentolate and 2.5% phenylephrine was applied topically to the eyes of 32 patients with diabetes mellitus and 25 age-matched controls. Epinephrine was mixed with buffered saline solution and used during the surgery. The surgical procedure included capsulorhexis, phacoemulsification in the posterior chamber and implantation into the capsular bag of a heparine surface-modified poly(methy1 metacrylate) IOL with an optic diameter of 5.0 mm. The durations of phacoemulsification and the whole surgical procedure were recorded. Measurements of the horizontal pupillary diameter were taken before surgery, after phacoemulsification and at the end of the surgery.

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C-terminal calcitonin gene-related peptide fragments and vasopressin but not somatostatin-28 induce miosis in monkeys

Cited by 7 publications

References 15 publications

Pupil size before and after phacoemulsification in nondiabetic and diabetic patients

Pupil size before and after phacoemulsification in nondiabetic and diabetic patients

Innervation of the Uvea by Galanin and Somatostatin Immunoreactive Axons in Macaques and Baboons

Cataract surgery and pupil size in patients with diabetes mellitus

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