C-type lectin receptors in anti-fungal immunity

Shiokawa, M.; Yamasaki, Sho; Saijo, Shinobu

doi:10.1016/j.mib.2017.11.004

Cited by 46 publications

(17 citation statements)

References 65 publications

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“…We identified sialic acid as a critical epitope at the surface of tumor cells responsible for their interaction with MR and dectin-1, highlighting the glycan specificity of the cooperation between dectin-1 and MR for sialic acid. These data support that heterodimeric complex formation among different CLRs diversifies host PRR repertoire and hence expand the ligand spectrum (29,30).…”

Section: Discussionsupporting

confidence: 67%

IL13-Mediated Dectin-1 and Mannose Receptor Overexpression Promotes Macrophage Antitumor Activities through Recognition of Sialylated Tumor Cells

Alaeddine

Prat

Poinsot

et al. 2019

Cancer Immunology Research

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Macrophage-mediated cytotoxicity is controlled by surface receptor expression and activation. Despite the numerous studies documenting the role of macrophage C-type lectin receptors (CLR) in pathogen elimination, little is known about their contribution to antitumor responses. Here, we report that IL13 inhibits T-cell lymphoma and ovarian adenocarcinoma development in tumor-bearing mice through the conversion of tumor-supporting macrophages to cytotoxic effectors, characterized by a CLR signature composed of dectin-1 and mannose receptor (MR). We show that dectin-1 and MR are critical for the recognition of tumor cells through sialic acid-specific glycan structure on their surface and for the subsequent activation of macrophage tumoricidal response. Finally, we validated that IL13 antitumor effect mediated by dectin-1 and MR overexpression on macrophages can extend to various types of human tumors. Therefore, these results identify these CLRs as potential targets to promote macrophage antitumor response and represent an attractive approach to elicit tumor-associated macrophage tumoricidal properties.

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Section: Discussionsupporting

confidence: 67%

IL13-Mediated Dectin-1 and Mannose Receptor Overexpression Promotes Macrophage Antitumor Activities through Recognition of Sialylated Tumor Cells

Alaeddine

Prat

Poinsot

et al. 2019

Cancer Immunology Research

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“…PRR from different classes have been shown to be expressed and functional in platelets, including those from C-type lectin receptors (CLR) and toll-like receptors (TLRs) families ( 2 , 8 , 9 ). CLR are a large family of surface proteins containing at least one carbohydrate-binding domain which are specialized in the recognition of bacterial, fungi, or viral glycans ( 10 – 12 ). Some viruses can exploit certain CLR for viral attachment and entry in host cells, including in platelets ( 13 , 14 ).…”

Section: Introductionmentioning

confidence: 99%

Platelets in Immune Response to Virus and Immunopathology of Viral Infections

2018

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Platelets are essential effector cells in hemostasis. Aside from their role in coagulation, platelets are now recognized as major inflammatory cells with key roles in the innate and adaptive arms of the immune system. Activated platelets have key thromboinflammatory functions linking coagulation to immune responses in various infections, including in response to virus. Recent studies have revealed that platelets exhibit several pattern recognition receptors (PRR) including those from the toll-like receptor, NOD-like receptor, and C-type lectin receptor family and are first-line sentinels in detecting and responding to pathogens in the vasculature. Here, we review the main mechanisms of platelets interaction with viruses, including their ability to sustain viral infection and replication, their expression of specialized PRR, and activation of thromboinflammatory responses against viruses. Finally, we discuss the role of platelet-derived mediators and platelet interaction with vascular and immune cells in protective and pathophysiologic responses to dengue, influenza, and human immunodeficiency virus 1 infections.

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“…These differences have important consequences for the specific contributions of CLRs to antimicrobial immunity, since they strongly affect ligand specificity and the induced immune responses, which can either support host defense or allow immune escape. The role of CLRs in host defense against fungal, viral and mycobacterial infections has recently been reviewed by others (Liu et al, 2017 ; Shiokawa et al, 2017 ; Bermejo-Jambrina et al, 2018 ). Instead, our review focuses on recent findings on the importance of CLRs in recognition of and responses to bacterial pathogens by APCs.…”

Section: Introductionmentioning

confidence: 99%

C-Type Lectin Receptors in Host Defense Against Bacterial Pathogens

Mnich

Dalen

Sorge

2020

Front. Cell. Infect. Microbiol.

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Antigen-presenting cells (APCs) are present throughout the human body-in tissues, at barrier sites and in the circulation. They are critical for processing external signals to instruct both local and systemic responses toward immune tolerance or immune defense. APCs express an extensive repertoire of pattern-recognition receptors (PRRs) to detect and transduce these signals. C-type lectin receptors (CLRs) comprise a subfamily of PRRs dedicated to sensing glycans, including those expressed by commensal and pathogenic bacteria. This review summarizes recent findings on the recognition of and responses to bacteria by membrane-expressed CLRs on different APC subsets, which are discussed according to the primary site of infection. Many CLR-bacterial interactions promote bacterial clearance, whereas other interactions are exploited by bacteria to enhance their pathogenic potential. The discrimination between protective and virulence-enhancing interactions is essential to understand which interactions to target with new prophylactic or treatment strategies. CLRs are also densely concentrated at APC dendrites that sample the environment across intact barrier sites. This suggests an-as yet-underappreciated role for CLR-mediated recognition of microbiota-produced glycans in maintaining tolerance at barrier sites. In addition to providing a concise overview of identified CLR-bacteria interactions, we discuss the main challenges and potential solutions for the identification of new CLR-bacterial interactions, including those with commensal bacteria, and for in-depth structure-function studies on CLR-bacterial glycan interactions. Finally, we highlight the necessity for more relevant tissue-specific in vitro, in vivo and ex vivo models to develop therapeutic applications in this area.

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C-type lectin receptors in anti-fungal immunity

Cited by 46 publications

References 65 publications

IL13-Mediated Dectin-1 and Mannose Receptor Overexpression Promotes Macrophage Antitumor Activities through Recognition of Sialylated Tumor Cells

IL13-Mediated Dectin-1 and Mannose Receptor Overexpression Promotes Macrophage Antitumor Activities through Recognition of Sialylated Tumor Cells

Platelets in Immune Response to Virus and Immunopathology of Viral Infections

C-Type Lectin Receptors in Host Defense Against Bacterial Pathogens

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