C-Type Lectins and Their Roles in Disease and Immune Homeostasis

Ebbecke, Tim; Diersing, Christina; Lindenwald, Dimitri; Stegmann, Felix; Lepenies, Bernd

doi:10.1016/b978-0-12-819475-1.00063-8

Cited by 2 publications

(1 citation statement)

References 449 publications

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“…CARD9 is an adaptor protein, which is involved in the Syk-dependent signaling cascade of CLRs bearing a hemITAM or being linked to an ITAM such as Dectin-1, Dectin-2 and Mincle [42]. These CLRs are most prominently involved in the recognition of fungal and bacterial pathogens, whereas their contribution to viral recognition is largely unknown [43]. Hence, to investigate the contribution of CARD9-dependent signaling of activating hemITAM-bearing or ITAM-coupled CLRs to virus control and neuropathology, CARD9 −/− mice were utilized in a murine TMEV infection model.…”

Section: Discussionmentioning

confidence: 99%

CARD9 Deficiency Increases Hippocampal Injury Following Acute Neurotropic Picornavirus Infection but Does Not Affect Pathogen Elimination

Pavasutthipaisit

Stoff²,

Ebbecke

et al. 2021

IJMS

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Neurotropic viruses target the brain and contribute to neurologic diseases. Caspase recruitment domain containing family member 9 (CARD9) controls protective immunity in a variety of infectious disorders. To investigate the effect of CARD9 in neurotropic virus infection, CARD9−/− and corresponding C57BL/6 wild-type control mice were infected with Theiler’s murine encephalomyelitis virus (TMEV). Brain tissue was analyzed by histology, immunohistochemistry and molecular analyses, and spleens by flow cytometry. To determine the impact of CARD9 deficiency on T cell responses in vitro, antigen presentation assays were utilized. Genetic ablation of CARD9 enhanced early pro-inflammatory cytokine responses and accelerated infiltration of T and B cells in the brain, together with a transient increase in TMEV-infected cells in the hippocampus. CARD9−/− mice showed an increased loss of neuronal nuclear protein+ mature neurons and doublecortin+ neuronal precursor cells and an increase in β-amyloid precursor protein+ damaged axons in the hippocampus. No effect of CARD9 deficiency was found on the initiation of CD8+ T cell responses by flow cytometry and co-culture experiments using virus-exposed dendritic cells or microglia-enriched glial cell mixtures, respectively. The present study indicates that CARD9 is dispensable for the initiation of early antiviral responses and TMEV elimination but may contribute to the modulation of neuroinflammation, thereby reducing hippocampal injury following neurotropic virus infection.

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Section: Discussionmentioning

confidence: 99%

CARD9 Deficiency Increases Hippocampal Injury Following Acute Neurotropic Picornavirus Infection but Does Not Affect Pathogen Elimination

Pavasutthipaisit

Stoff²,

Ebbecke

et al. 2021

IJMS

Self Cite

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Association Between Diabetes Mellitus–Tuberculosis and the Generation of Drug Resistance

Cornejo-Báez,

Zenteno-Cuevas,

Luna-Herrera

2024

Microorganisms

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Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains one of the leading infectious causes of death globally, with drug resistance presenting a significant challenge to control efforts. The interplay between type 2 diabetes mellitus (T2DM) and TB introduces additional complexity, as T2DM triples the risk of active TB and exacerbates drug resistance development. This review explores how T2DM-induced metabolic and immune dysregulation fosters the survival of Mtb, promoting persistence and the emergence of multidrug-resistant strains. Mechanisms such as efflux pump activation and the subtherapeutic levels of isoniazid and rifampicin in T2DM patients are highlighted as key contributors to resistance. We discuss the dual syndemics of T2DM–TB, emphasizing the role of glycemic control and innovative therapeutic strategies, including efflux pump inhibitors and host-directed therapies like metformin. This review underscores the need for integrated diagnostic, treatment, and management approaches to address the global impact of T2DM–TB comorbidity and drug resistance.

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C-Type Lectins and Their Roles in Disease and Immune Homeostasis

Cited by 2 publications

References 449 publications

CARD9 Deficiency Increases Hippocampal Injury Following Acute Neurotropic Picornavirus Infection but Does Not Affect Pathogen Elimination

CARD9 Deficiency Increases Hippocampal Injury Following Acute Neurotropic Picornavirus Infection but Does Not Affect Pathogen Elimination

Association Between Diabetes Mellitus–Tuberculosis and the Generation of Drug Resistance

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