2020
DOI: 10.3390/ijms21145122
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C-Type Lectins in Veterinary Species: Recent Advancements and Applications

Abstract: C-type lectins (CTLs), a superfamily of glycan-binding receptors, play a pivotal role in the host defense against pathogens and the maintenance of immune homeostasis of higher animals and humans. CTLs in innate immunity serve as pattern recognition receptors and often bind to glycan structures in damage- and pathogen-associated molecular patterns. While CTLs are found throughout the whole animal kingdom, their ligand specificities and downstream signaling have mainly been studied in humans and in model organis… Show more

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Cited by 18 publications
(8 citation statements)
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References 145 publications
(163 reference statements)
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“…CD248 shares the typical C-type lectin domain of the immunoglobulin superfamily, potentiating a role for CD248 in regulating innate and adaptive immunity. 21 Although initially identified on tumor blood vessels and defined as an abnormally expressed marker of tumor endothelial cells, 22 CD248 has been recently shown to be expressed in non-endothelial 23 immunocompetent cells, including CD8+ T cells, 24,25 supporting its potential link to T cell-involved immune reaction. Vascular inflammatory reactions seem to play a pivotal role in the development and progression of aortic aneurysms.…”
Section: Discussionmentioning
confidence: 99%
“…CD248 shares the typical C-type lectin domain of the immunoglobulin superfamily, potentiating a role for CD248 in regulating innate and adaptive immunity. 21 Although initially identified on tumor blood vessels and defined as an abnormally expressed marker of tumor endothelial cells, 22 CD248 has been recently shown to be expressed in non-endothelial 23 immunocompetent cells, including CD8+ T cells, 24,25 supporting its potential link to T cell-involved immune reaction. Vascular inflammatory reactions seem to play a pivotal role in the development and progression of aortic aneurysms.…”
Section: Discussionmentioning
confidence: 99%
“…Mincle is activated by several PAMPs including the Mycobacterium tuberculosis cell wall glycolipid trehalose dimycolate (TDM) [ 41 ] and its C22 synthetic counterpart, trehalose dibehenate (TDB, Fig 1 ) [ 42 ], as well as α-mannosyl residues found on Malassezia fungi [ 43 ]. To date, there have only been limited studies examining the potential of Mincle adjuvants to augment immune responses for veterinary vaccine antigens [ 44 ], with studies into the use of TDB and amide-derivatives of TDB being the first to demonstrate the potential of these ligands in in vivo veterinary models [ 39 , 45 , 46 ].…”
Section: Introductionmentioning
confidence: 99%
“…In addition to interactions with microbial cells, we also demonstrated the potential for AsCTL-42 to interact with mammalian cells. As myeloid CLRs can sense microbes such as Gram-negative bacteria, fungi, Mycobacterium spp., trematodes, and viruses [46,47], their modulation has implications for intestinal microbial communities. We found that AsCTL-42 interacts with selected human and murine myeloid CLRs (Figure 5).…”
Section: Discussionmentioning
confidence: 99%