C-Type Natriuretic Peptide (CNP) and Postnatal Linear Growth

Prickett, Timothy C. R.; Espiner, Eric A.

doi:10.1007/978-1-4419-1795-9_166

Cited by 7 publications

(2 citation statements)

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“…Plasma concentrations of CNP forms (i.e. CNP‐22 and NTproCNP) in adults appear to be relatively stable, but the effect of age, gender and anthropometric measures – and changing organ function – in adult subjects has not been studied. Establishing any such relation is clearly important when interpreting values that are now being reported with increasing frequency in a variety of clinical settings .…”

Section: Introductionmentioning

confidence: 99%

Impact of age, phenotype and cardio‐renal function on plasma C‐type and B‐type natriuretic peptide forms in an adult population

Prickett

Olney

Cameron

et al. 2013

Clinical Endocrinology

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Section: Introductionmentioning

confidence: 99%

Impact of age, phenotype and cardio‐renal function on plasma C‐type and B‐type natriuretic peptide forms in an adult population

Prickett

Olney

Cameron

et al. 2013

Clinical Endocrinology

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“…The family shares a ring structure consisting of 17 amino acid residues, flanked by two cysteine residues forming a disulfide bond critical to biological activity (Pandey, 2005 ; Potter et al, 2006 ). Three forms of the peptide occur: expression of the Nppc (Natriuretic Peptide Precursor-C) gene elicits the initial 126 residue preproCNP (Tawaragi et al, 1990 ) resulting in the 103 residue proCNP, which is cleaved intracellularly to produce CNP-53 and a biologically inactive amino terminal fragment, NTproCNP, both of which are secreted extracellularly in equimolar amounts (Wu et al, 2003 ; Prickett and Espiner, 2012 ). Further extracellular processing results in CNP-22, thought to be the fully active form of the peptide, with CNP-53 proposed as a storage form (Barr et al, 1996 ).…”

Section: Introductionmentioning

confidence: 99%

Environmental Enrichment Elicits a Transient Rise of Bioactive C-Type Natriuretic Peptide in Young but Not Aged Rats

Rapley

Prickett

Dalrymple‐Alford

et al. 2018

Front. Behav. Neurosci.

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Beneficial molecular and neuroplastic changes have been demonstrated in response to environmental enrichment (EE) in laboratory animals across the lifespan. Here, we investigated whether these effects extend to C-type Natriuretic Peptide (CNP), a widely expressed neuropeptide with putative involvement in neuroprotection, neuroplasticity, anxiety, and learning and memory. We determined the CNP response in 36 young (8–9 months) and 36 aged (22–23 months) male PVGc hooded rats that were rehoused with new cage mates in either standard laboratory cages or EE for periods of 14 or 28 days. Tissues were rapidly excised from four brain regions associated with memory formation (dorsal hippocampus, retrosplenial cortex, medial prefrontal cortex, and mammillary bodies) plus the occipital cortex and hypothalamus, and immediately frozen. Radioimmunoassay was used to measure bioactive CNP and the amino-terminal fragment of proCNP, NTproCNP. Because CNP but not NTproCNP is rapidly degraded at source, NTproCNP reflects CNP production whereas the ratio NTproCNP:CNP is a biomarker of CNP's local degradation rate. EE increased CNP at 14 days in all brain regions in young, but not old rats; this effect in young rats was lost at 28 days in all regions of interest. NTproCNP:CNP ratio, but not NTproCNP, was reduced in all regions by EE at 14 days in young rats, but not in old rats, which suggests a period of reduced degradation or receptor mediated clearance, rather than increased production of CNP in these young EE rats. Aged rats tended to show reduced NTproCNP:CNP ratios but this did not occur in dorsal hippocampus or mammillary bodies. This is the first study demonstrating modulation of CNP protein concentrations, and the effect of age, in response to environmental stimulation. Furthermore, it is the first to show that changes in degradation rate in vivo may be an important component in determining CNP bioactivity in neural tissues.

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C-Type Natriuretic Peptide and Its Receptors

Mark

Goetze

2021

Encyclopedia of Molecular Pharmacology

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C-Type Natriuretic Peptide (CNP) and Postnatal Linear Growth

Cited by 7 publications

References 50 publications

Impact of age, phenotype and cardio‐renal function on plasma C‐type and B‐type natriuretic peptide forms in an adult population

Impact of age, phenotype and cardio‐renal function on plasma C‐type and B‐type natriuretic peptide forms in an adult population

Environmental Enrichment Elicits a Transient Rise of Bioactive C-Type Natriuretic Peptide in Young but Not Aged Rats

C-Type Natriuretic Peptide and Its Receptors

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