C-Type Natriuretic Peptide Dampens Fibroblast Growth Factor-23 Expression Through MAPK Signaling Pathway in Human Mesangial Cells

C-type natriuretic peptide stimulates osteoblastic proliferation and collagen-X expression but suppresses fibroblast growth factor-23 expression in vitro

“…However, the proliferative regulation of CNP shows significant diversity among different cell types. Two previous studies from Khambata's and our laboratory revealed that CNP caused a concentrationdependent inhibition of cell proliferation in vascular smooth muscle cells and renal mesangial cells, but led to a concentration-dependent augmentation of cell growth in vascular endothelial cells [8,27]. Although the potential mechanism is still unclear to date, further studies on cell cycle regulation may provide more insight into the different proliferative regulations of CNP on different cells.…”

“…Both of them could result in a significant elevation in intracellular cyclic guanosine monophosphate (cGMP) after selectively binding to the transmembrane natriuretic peptide receptor (NPR)-B [4,5]. Besides little effect on blood pressure and body fluid homeostasis, CNP mainly elicits local vasorelaxation, inhibits organ remodeling, accelerates reendothelialization, and antagonizes the renin-angiotensin-aldosterone system in a paracrine manner [6][7][8]. However, several lines of evidence have disclosed that CNP also plays a pivotal role in longitudinal bone growth.…”

Genome‑wide identification, organization, and expression profiles of the chicken fibroblast growth factor genes in public databases and Vietnamese indigenous Ri chickens against highly pathogenic avian influenza H5N1 virus infection

“…activation of MAPK family proteins, STATs, or NF-κB subunits [3,4,7]. Our analysis demonstrated high interactions among chicken FGF family genes/proteins but limited interaction between FGF genes/proteins with MAPK/NF-κB signaling pathway proteins.…”

“…Our analysis demonstrated high interactions among chicken FGF family genes/proteins but limited interaction between FGF genes/proteins with MAPK/NF-κB signaling pathway proteins. In contrast, the high interaction between human FGF family genes/proteins and MAPK/NF-κB signaling pathway components and the function of FGF genes in humans to control the immune response to pathogens have been investigated [2][3][4]7]. The results indicated that the function of FGF protein inactivation and the association of FGFs with molecular signaling pathway proteins and immune system regulation in chickens should be investigated and evaluated in vitro and in vivo.…”

“…These growth factors are highly conserved and found in several animal species, from nematodes and zebrafish to mice and humans [1]. FGFs play a role in cellular proliferation, migration, and differentiation, mitogenesis, angiogenesis, embryogenesis, and wound healing through the binding to and activation of fibroblast growth factor receptors (FGFRs), the main signaling pathway of which is the RAS/MAP kinase pathway [2][3][4]. Recently, it has been demonstrated that FGFs play an important role in the regeneration of damaged tissues, including skin, bone, blood vessels, muscle, cartilage, adipose tissue, tooth, tendon/ligament, and nerve, by acting on several signaling pathways, such as Wnt/beta-catenin, JAK-STAT, and PI3K/AKT pathways [5][6][7].…”