C-X-C motif receptor 7 in gastrointestinal cancer

Yun, Hwan‐Jung; Ryu, Hyewon; Choi, Yoon Seok; Song, Ik‐Chan; Jo, Deog‐Yeon; Kim, Samyong

doi:10.3892/ol.2015.3407

Cited by 4 publications

(5 citation statements)

References 65 publications

(120 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CXCR7 is usually upregulated in GC tissues with a positivity rate of 63–84.62% by IHC, which correlates with deep invasion, LN metastasis, advanced stages, and bad outcome of patients . Also, CXCR7 is highly expressed in the majority of tumor‐associated vessels and related with tumor neovascularization via regulating the secretion of proangiogenic factors such as interleukin‐8 and VEGF . CXCR7 overexpression may affect disease progression by stimulating proliferation, invasion, migration, adhesion, and angiogenesis of GC through β ‐arrestin‐dependent downstream signalings, including Akt, ERK1/2, p38 MAPK, JAK2/STAT3, and stress‐activated protein kinase (SAPK) pathways .…”

Section: Cross‐talks Of Cxcl12/cxcr4 Axis With Other Chemokines and Cmentioning

confidence: 99%

“…It is demonstrated that inhibition of CXCR7 pathway leads to an antitumor activity in various solid malignancies originated from colon, liver, pancreas, and head and neck . CCX754 as one of CXCR7 antagonists significantly suppresses the growth of lung cancer in both immunodeficient and immunocompetent mouse models, which are engrafted by human A549 and mouse LL/2 Lewis lung carcinoma cell lines, respectively .…”

Section: Cross‐talks Of Cxcl12/cxcr4 Axis With Other Chemokines and Cmentioning

confidence: 99%

“…The maximal effect of CXCL12 on the CXCR7 homodimer conformation is also increased by 40% by AMD3100, which may indicate an AMD3100‐mediated activation of CXCR7 pathways . However, there are still rare reports about the efficacy of specific inhibitors of CXCR7 including CCX754, CCX771, CCX733, and CCX2066 in GC until now .…”

Section: Cross‐talks Of Cxcl12/cxcr4 Axis With Other Chemokines and Cmentioning

confidence: 99%

See 2 more Smart Citations

Inhibition of CXCL12/CXCR4 axis as a potential targeted therapy of advanced gastric carcinoma

et al. 2017

View full text Add to dashboard Cite

The whole outcome for patients with gastric carcinoma (GC) is very poor because most of them remain metastatic disease during survival even at diagnosis or after surgery. Despite many improvements in multiple strategies of chemotherapy, immunotherapy, and targeted therapy, exploration of novel alternative therapeutic targets is still warranted. Chemokine receptor 4 (CXCR4) and its chemokine ligand 12 (CXCL12) have been identified with significantly elevated levels in various malignancies including GC, which correlates with the survival, proliferation, angiogenesis, and metastasis of tumor cells. Increasing experimental evidence suggests an implication of inhibition of CXCL12/CXCR4 axis as a promising targeted therapy, although there are rare trials focused on the therapeutic efficacy of CXCR4 inhibitors in GC until recently. Therefore, it is reasonable to infer that specific antagonists or antibodies targeting CXCL12/CXCR4 axis alone or combined with chemotherapy will be effective and worthy of further translational studies as a potential treatment strategy in advanced GC.

show abstract

Section: Cross‐talks Of Cxcl12/cxcr4 Axis With Other Chemokines and Cmentioning

confidence: 99%

Section: Cross‐talks Of Cxcl12/cxcr4 Axis With Other Chemokines and Cmentioning

confidence: 99%

Section: Cross‐talks Of Cxcl12/cxcr4 Axis With Other Chemokines and Cmentioning

confidence: 99%

See 1 more Smart Citation

Inhibition of CXCL12/CXCR4 axis as a potential targeted therapy of advanced gastric carcinoma

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Another study demonstrated that the IL-8-regulated CXCR7 stimulated EGFR Signaling to promote prostate cancer growth (Singh, 2011). In a study conducted by Yun et al ., it is reported that CXCR7 expression was increased in most of the tumor cells compared with the normal cells and is involved in cell proliferation, migration, survival, invasion and angiogenesis during the initiation and progression of many cancer types including prostate cancer (Yun, 2015). It was also shown in (Lin, 2014) that elevated expression of CXCR7 contributes to HCC growth and invasiveness via activation of MAPK and angiogenesis signaling pathways and they also conclude that targeting CXCR7 may prevent metastasis and provide a potential therapeutic strategy for hepatocellular carcinoma (HCC).…”

Section: Literature Search Of the Top Hub Targetsmentioning

confidence: 99%

Disease mechanism, drug-target and biomarker prediction software: Application on prostate cancer and validation

Altay

Nurmemmedov

Kesari

et al. 2017

Preprint

View full text Add to dashboard Cite

We introduce an R software package for condition-specific gene regulatory network analysis based on DC3NET algorithm. We also present an application of it on a real prostate dataset and demonstrate the benefit of the software. We performed genome-wide differential gene network analysis with the software on the LnCap androgen stimulated and deprived prostate cancer gene expression datasets (GSE18684) and inferred the androgen stimulated prostate cancer specific differential network. As an outstanding result, CXCR7 along with CXCR4 appeared to have the most important role in the androgen stimulated prostate specific genome-wide differential network. This blind estimation is strongly supported from the literature. The critical roles for CXCR4, a receptor over-expressed in many cancers, and CXCR7 on mediating tumor metastasis, along with their contributions as biomarkers of tumor behavior as well as potential therapeutic target were studied in several other types of cancers. In fact, a pharmaceutical company had already developed a therapy by inhibiting CXCR4 to block non-cancerous immuno-suppressive and pro-angiogenic cells from populating the tumor for disrupting the cancer environment and restoring normal immune surveillance functions. Considering this strong confirmation, our inferred regulatory network might reveal the driving mechanism of LnCap androgen stimulated prostate cancer. Because, CXCR4 appeared to be in the center of the largest subnetwork of our inferred differential network. Moreover, enrichment analyses for the largest subnetwork of it appeared to be significantly enriched in terms of axon guidance, fc gamma R-mediated phagocytosis and endocytosis. This also conforms with the recent literature in the field of prostate cancer.We demonstrate how to derive condition-specific gene targets from expression datasets on genome-wide level using differential gene network analysis. Our results showed that differential gene network analysis worked well in a prostate cancer dataset, which suggest the use of this approach as essential part of current expression data processing.Availability: The introduced R software package available in CRAN at https://cran.r-project.org/web/packages/dc3net and also at https://github.com/altayg/dc3net . CC-BY-NC 4.0 International license not peer-reviewed) is the author/funder. It is made available under a The copyright holder for this preprint (which was . http://dx.doi.org/10.1101/129742 doi: bioRxiv preprint first posted online Apr. 24, 2017; 2 BackgroundProstate cancer is the second most common cancer in the male population, with an estimated 417,000 new cases diagnosed each year in Europe (Ferlay, 2013). The activation of androgen receptor (AR) through androgens plays a crucial role in the development and progression of prostate cancer (Kaur, 2016; Anantharaman, 2015; Choudhary, 2011;Massie, 2011). For early detection of prostate cancer, prostate specific antigen (PSA) screening method has been used widely as a diagnostic tool (Karatas, 2015). However, PSA fails...

show abstract

“…Chemokines are a group of small chemotactic cytokines that interact with seven-transmembrane G-protein-coupled receptors, and this interaction is involved in organ development, host immune responses and other physiological processes that direct cells to specific sites in the body (12,13). Approximately 50 human genes encode chemokine ligands, and >20 chemokine receptor (CCR) genes have been identified since the term 'chemokine' was originally introduced in 1992 as an abbreviated form of chemotactic cytokine (1,14).…”

Section: Introductionmentioning

confidence: 99%

C‑C motif chemokine receptors in gastric cancer (Review)

et al. 2017

Self Cite

View full text Add to dashboard Cite

Abstract. Gastric cancer is the fifth most common cancer and the third leading cause of cancer-associated mortality worldwide. Despite recent advances in molecular and clinical research, patients with gastric cancer at an advanced stage have a dismal prognosis and poor survival rates, and systemic treatment relies predominantly on traditional cytotoxic chemotherapy. To improve patients' quality of life and survival, an improved understanding of the complex molecular mechanisms involved in gastric cancer progression and treatment resistance, and of its clinical application in the development of novel targeted therapies, is urgently required. Chemokines are a group of small chemotactic cytokines that interact with seven-transmembrane G-protein-coupled receptors, and this interaction serves a crucial role in various physiological processes, including organ development and the host immune response, to recruit cells to specific sites in the body. There is also accumulating evidence that chemokines and chemokine receptors (CCRs) contribute to tumor development and progression, as well as metastasis. However, research regarding the functional roles of chemokines and their receptors in cancer is dynamic and context-dependent, and much remains to be elucidated, although various aspects have been explored extensively. In gastric cancer, C-C motif CCRs are involved in the biological behavior of tumor cells, including the processes of growth, invasion and survival, as well as the epithelial-mesenchymal transition. In the present review, attention is given to the clinical relevance of C-C motif CCRs in the development, progression, and metastasis of gastric cancer, particularly CCR7 and CCR5, which have been investigated extensively, as well as their potential therapeutic implications.

show abstract

C-X-C motif receptor 7 in gastrointestinal cancer

Cited by 4 publications

References 65 publications

Inhibition of CXCL12/CXCR4 axis as a potential targeted therapy of advanced gastric carcinoma

Inhibition of CXCL12/CXCR4 axis as a potential targeted therapy of advanced gastric carcinoma

Disease mechanism, drug-target and biomarker prediction software: Application on prostate cancer and validation

C‑C motif chemokine receptors in gastric cancer (Review)

Contact Info

Product

Resources

About