Objective To evaluate the efficacy of percutaneous electrolysis for the treatment of patients with tendinopathies. Data sources A systematic search of publications was conducted in Pubmed, Cinahl, Medline, Scopus and Web of Science. Methods The Oxford 2011 Levels of Evidence and the Jadad scale were used to assess the quality of studies. The mean and standard deviation were obtained for each study group and used to calculate the effect size. The DerSimonian and Laird method was used to develop a random-effects model. Results Of the 14 articles, four applied percutaneous electrolysis to the knee, three to the shoulder, three to the elbow, two to the hip and two to the ankle and foot. A meta-analysis on intensity of pain (evaluated with algometer and the Visual Analogue Scale) was performed on studies comparing percutaneous electrolysis with a control group, indicating that the groups treated with percutaneous electrolysis had better results ( p = 0.01). Although percutaneous electrolysis did not overcome the analgesic effect achieved by corticosteroid injections. Conclusions The percutaneous electrolysis is effective for the treatment of tendinopathies. The combination of this technique with eccentric training has proven to be one of the most effective treatments to date for improving pain. PROSPERO Registration: CRD42021230005.