2015
DOI: 10.1007/s13277-015-3806-3
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C14ORF166 overexpression is associated with pelvic lymph node metastasis and poor prognosis in uterine cervical cancer

Abstract: C14ORF166 (chromosome 14 open reading frame 166) is a transcriptional repressor related to the regulation of centrosome architecture. However, the role of C14ORF166 in the development and progression of cancer remains largely unknown. The aim of this study was to investigate the expression and clinicopathological significance of C14ORF166 in cervical cancer. C14ORF166 expression was analyzed using quantitative real-time PCR (RT-PCR) and Western blotting in cervical cancer cell lines and eight paired cervical c… Show more

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Cited by 26 publications
(26 citation statements)
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“…Second, we did not consider the genomic data of the biopsy of these patients. In fact, the genomic characteristics of cervical cancer tissues could be helpful for the prediction of lymph node metastases (33,34). Thus, in our future work, we will try to incorporate more genetic information for our prediction model.…”
Section: Discussionmentioning
confidence: 99%
“…Second, we did not consider the genomic data of the biopsy of these patients. In fact, the genomic characteristics of cervical cancer tissues could be helpful for the prediction of lymph node metastases (33,34). Thus, in our future work, we will try to incorporate more genetic information for our prediction model.…”
Section: Discussionmentioning
confidence: 99%
“…Blocking C14orf166 will reduce mRNA translation by 50%, severely impairing cellular activity (12). However, there are also genes associated with oncogenesis and tumor invasion behavior under the regulation of C14orf166, and overexpression of C14orf166 was identified in multiple tumor tissues relative to its adjacent normal tissues (1619). …”
Section: Discussionmentioning
confidence: 99%
“…The dysregulated intracellular JAK2/STAT3 signaling pathway is common in numerous types of carcinoma and is associated with malignancy and poor prognosis, an antagonist of the pathway attenuates tumor bearing and improves drug efficacy (33,34). Zhang et al (19) identified that C14orf166 overexpression was associated with lymph node involvement and shorter OS and DFS in cervical cancer, which was associated with abnormal JAK2/STAT3 pathway activity. Chen et al (35) reported that C14orf166, together with acylglycerol kinase, were identified as JH2-interacting proteins, which consecutively activated the JAK2/STAT3 signaling pathway to promote esophageal squamous cell generation and enhanced the cancer stem cell population.…”
Section: Discussionmentioning
confidence: 99%
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“…1 The incidence of CC is attributed to a wide variety of risk factors including, genetic susceptibility, viral infections and environmental factors, all of which have been correlated with the etiology of CC. 2 CC ranks second regarding cancer-related deaths globally, with statistics estimating there to be as many as 474,000 female-deaths due to the disease by the year of 2030. 3 Furthermore, a clinical statistics report indicated there to be 61,691 cases of CC in China, with 29,526 confirmed deaths, of which both figures represented 10% of cases globally.…”
Section: Introductionmentioning
confidence: 99%