C16 laminin peptide increases angiotropic extravascular migration of human melanoma cells in a shell-less chick chorioallantoic membrane assay

Lugassy, Claire; Kleinman, Hynda K.; Vernon, Stephen E.; Welch, Danny R.; Barnhill, Raymond L.

doi:10.1111/j.1365-2133.2007.08120.x

Cited by 38 publications

(38 citation statements)

References 11 publications

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“…5 Here, we describe for the first time an extraordinary case of malignant melanoma of the brain most likely metastatic, demonstrating florid angiotropism. This specific observation reinforces the hypothesis of melanoma migration along the external surfaces of microvessels in the brain and in other locations.…”

Section: Introductionmentioning

confidence: 85%

Conspicuous Angiotropism of Malignant Melanoma Involving the Brain: Implications for Extravascular Migratory Metastasis

Barnhill¹,

Benson²,

Lugassy³

2009

The American Journal of Dermatopathology

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Angiotropism is the presence of tumor cells closely apposed to the abluminal surfaces of blood and lymphatic vessels without intravasation. Previous studies have strongly suggested that angiotropism in melanoma could be a marker for extravascular migratory metastasis, the migration of tumor cells along the external surfaces of vessels. We describe for the first time a patient with malignant melanoma of the brain most likely metastatic, which was floridly angiotropic as evidenced by extensive spread of melanoma cells along the external surfaces of brain microvessels. The location of this angiotropic melanoma in the brain, together with the analogies between extravascular migratory metastasis and the neoplastic glial invasion of the nervous system, reinforces the hypothesis of extravascular migration of melanoma cells as a means of tumor spread, particularly along the abluminal surfaces of vessels, in the brain and in other organs.

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Section: Introductionmentioning

confidence: 85%

Conspicuous Angiotropism of Malignant Melanoma Involving the Brain: Implications for Extravascular Migratory Metastasis

Barnhill¹,

Benson²,

Lugassy³

2009

The American Journal of Dermatopathology

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“…48,49,51 The presence of the C16 laminin peptide increases the distance of angiotropic migration of melanoma cells in vitro. 52 Furthermore, ex vivo and in vivo studies with time-lapse video microscopy have documented the migration of melanoma cells along the abluminal surface of vascular channels without blood vessel invasion, arguing against angiotropism just representing an early stage in the vascular invasion process. [53][54][55][56][57] It has been hypothesized that the interaction of melanoma cells with the abluminal vascular surface recapitulates embryonic migration of neural crest cells through pericyte mimicry.…”

Section: Extravascular Migratory Metastasis and Angiotropismmentioning

confidence: 99%

Lymphatic invasion and angiotropism in primary cutaneous melanoma

Moy

Duncan

Kraft

2017

Laboratory Investigation

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Access of melanoma cells to the cutaneous vasculature either via lymphatic invasion or angiotropism is a proposed mechanism for metastasis. Lymphatic invasion is believed to be a mechanism by which melanoma cells can disseminate to regional lymph nodes and to distant sites and may be predictive of adverse outcomes. Although it can be detected on hematoxylin-and eosin-stained sections, sensitivity is markedly improved by immunohistochemistry for lymphatic endothelial cells. Multiple studies have reported a significant association between the presence of lymphatic invasion and sentinel lymph node metastasis and survival. More recently, extravascular migratory metastasis has been suggested as another means by which melanoma cells can spread. Angiotropism, the histopathologic correlate of extravascular migratory metastasis, has also been associated with melanoma metastasis and disease recurrence. Although lymphatic invasion and angiotropism are not currently part of routine melanoma reporting, the detection of these attributes using ancillary immunohistochemical stains may be useful in therapeutic planning for patients with melanoma.

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“…Angiotropism has been defined histologically as the presence of melanoma cells disposed along the external surfaces of vessels at the invasive front of the tumor or in nearby tissues without intravasation [5,8]. Furthermore, angiotropism has also been demonstrated as a prognostic factor of metastasis [9,10], as well as a microscopic marker of EVMM [11,12]. Finally, the concepts of angiotropism and EVMM are now recognized by the international scientific community as an important alternative means of melanoma (and other tumor) dissemination and as key subjects of future cancer research [10,[13][14][15].…”

Section: Reviewmentioning

confidence: 99%

Angiotropism and extravascular migratory metastasis in melanoma: from concept to gene expression

Lugassy

Barnhill

2011

Expert Review of Dermatology

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The concepts of angiotropism and extravascular migratory metastasis (EVMM) are now recognized by the international scientific community as a key subject of cancer research. In EVMM, tumor cells migrate along vessels (angiotropic EVMM) or along other anatomical tracks, such as nerves (neurotropic EVMM). Angiotropism has been shown to be a prognostic factor for melanoma metastasis, as well as a microscopic marker of EVMM. For some time, analogies of EVMM with neural crest cell migration and vasculogenesis/angiogenesis have been recognized. Finally, a recent gene microarray ana lysis has led to the detection of genes potentially involved in EVMM. This article will review our current understanding of EVMM, and new perspectives on this promising field of investigation. Keywords: advancing front of the tumor • angiogenesis • angiotropism • epithelial-mesenchymal transition • extravascular migratory metastasis • laminin • neural crest cell migration • neurotropism • Treacle • vasculogenesisAngiotropism and extravascular migratory metastasis in melanoma: from concept to gene expression

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C16 laminin peptide increases angiotropic extravascular migration of human melanoma cells in a shell-less chick chorioallantoic membrane assay

Abstract: The results of this study suggest that the C16 laminin gamma1 chain peptide has angiotropic, extravascular migration-promoting activity on human melanoma cells, and might be a molecular target for preventing melanoma metastasis.

Cited by 38 publications

References 11 publications

Conspicuous Angiotropism of Malignant Melanoma Involving the Brain: Implications for Extravascular Migratory Metastasis

Conspicuous Angiotropism of Malignant Melanoma Involving the Brain: Implications for Extravascular Migratory Metastasis

Lymphatic invasion and angiotropism in primary cutaneous melanoma

Angiotropism and extravascular migratory metastasis in melanoma: from concept to gene expression

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