2015
DOI: 10.1016/j.molimm.2015.05.010
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C1q, antibodies and anti-C1q autoantibodies

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Cited by 61 publications
(48 citation statements)
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References 126 publications
(132 reference statements)
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“…Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the generation of autoantibodies (reviewed in (Beurskens et al, 2015)) and IC deposition leading to chronic inflammation and tissue/organ destruction. C1q–deficiency in humans results in development of SLE or an SLE-like syndrome (Manderson et al, 2004; Stegert et al, 2015) consistent with a role for C1q in clearance of IC.…”
Section: Classical Functions: Complement Phagocytosis and Cytokinmentioning
confidence: 99%
“…Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the generation of autoantibodies (reviewed in (Beurskens et al, 2015)) and IC deposition leading to chronic inflammation and tissue/organ destruction. C1q–deficiency in humans results in development of SLE or an SLE-like syndrome (Manderson et al, 2004; Stegert et al, 2015) consistent with a role for C1q in clearance of IC.…”
Section: Classical Functions: Complement Phagocytosis and Cytokinmentioning
confidence: 99%
“…Until now, only TPOAb serve as a predictor of postpartum thyroiditis (PPT), apart from thyroid ultrasound [7]. Complement-activating TPOAb were found to be increased Anti-C1q antibodies in pregnancy V C 2016 British Society for Immunology, Clinical and Experimental Immunology, 186: [10][11][12][13][14][15][16][17] in women with PPT [31,32]. However, only approximately half the TPOAb-positive women developed PPT after delivery, and the mechanisms that might be involved remain unclear.…”
Section: Discussionmentioning
confidence: 99%
“…The patient did have positive anti-C1q IgG antibodies. C1q antibodies are present in 2–8% of the healthy population but are present in 30–48% of SLE patients [17, 19]. C1q antibodies are associated with intense activation of the classical complement pathway resulting in low levels of C1q, C4, and C2 [17, 20].…”
Section: Discussionmentioning
confidence: 99%