Solitary bone plasmacytoma (SBP) is defined as a single lytic lesion due to monoclonal plasma cell (PC) infiltration, with or without soft-tissue extension [1]. It represents 2-5% of PC malignancies [2]. Bone marrow aspiration and biopsy are required to evaluate PC morphology and infiltration. Additionally to computed tomography (CT), magnetic resonance image (MRI) or fluorodeoxyglucose positron emission tomography (FDG-PET) are needed to exclude additional lesions [1, 3].SBP of the craniocervical junction is a rare tumour. When there is vertebral instability, surgical intervention is recommended, followed by radiation therapy [4].