C221: The differences in expression of microRNA in urine of bladder cancer patients and healthy controls

Brisuda, A.; Pospı́šilová, Šárka; Soukup, Viktor; Hrbáček, Jan; Čapoun, Otakar; Mareš, Jaroslav; Pazourková, E.; Korabečná, Marie; Hořı́nek, A.; Hanuš, Tomáš; Babjuk, Marek

doi:10.1016/s1569-9056(14)61586-4

Cited by 1 publication

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“…However, Mahdavinezhad et al ( 71 , 72 ) found that 64% of bladder cancer tissues possess high levels of miR-30b compared with normal tissues. A study in the USA showed elevated expression of miR-30b in the urine of patients with high-grade urothelial carcinoma ( 73 ), whereas two other studies from the USA and the Czech Republic showed significantly reduced urine miR-30b levels in patients with bladder cancer ( 70 , 74 ). Therefore, the role of miR-30b in bladder cancer is unclear and should be investigated further.…”

Section: Role Of Mir-30b In Cancermentioning

confidence: 99%

Roles and regulatory mechanisms of miR‑30b in cancer, cardiovascular disease, and metabolic disorders (Review)

et al. 2020

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MicroRNAs (miRNAs) are non-coding RNAs 21-23 nucleotides in length that regulate gene expression, and thereby modulate signaling pathways and protein synthesis in both physiological and pathogenic processes. miR-30b inhibits cell proliferation, migration, invasion and epithelial-mesenchymal transformation in multiple types of cancer. In addition to its role in several types of neoplasias, miR-30b has been shown to exhibit essential roles in cardiovascular and metabolic diseases. In the present review, an overview of the biological functions of miR-30b and its role in the pathogenesis of neoplastic, cardiovascular and metabolic diseases is provided. miR-30b is a potential candidate for clinical development as a diagnostic and prognostic biomarker, therapeutic agent and drug target. However, further research is required to elucidate its role in health and disease and to harness its potential clinical utility.

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Section: Role Of Mir-30b In Cancermentioning

confidence: 99%