2008
DOI: 10.1016/j.leukres.2007.12.013
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C3435T polymorphism of the MDR1 gene is not associated with P-glycoprotein function of leukemic blasts and clinical outcome in patients with acute myeloid leukemia

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Cited by 30 publications
(15 citation statements)
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“…For example, van der Holt et al (2006) reported no associations between genotypes involving MDR1 C1236T, G2677T, or C3435T polymorphisms and P-gp expression and function in leukemic blasts, MDR1 expression, CR rates, or survival rates in a study of 150 patients Ն60 years of age with AML who were treated in a phase 3 study. Other studies reported no associations between MDR1 C3435T polymorphisms and P-gp function in leukemic blasts (Jamroziak et al, 2005(Jamroziak et al, , 2006Hur et al, 2008) or responses and long-term outcomes among patients with AML (Jamroziak et al, 2005;Hur et al, 2008). In addition, the C/C genotype of C3435T was not associated with prognoses in a study of 143 Indian patients with AML (Rao et al, 2010).…”
Section: Mdr In Acute Myeloid Leukemia and Other Acutementioning
confidence: 92%
“…For example, van der Holt et al (2006) reported no associations between genotypes involving MDR1 C1236T, G2677T, or C3435T polymorphisms and P-gp expression and function in leukemic blasts, MDR1 expression, CR rates, or survival rates in a study of 150 patients Ն60 years of age with AML who were treated in a phase 3 study. Other studies reported no associations between MDR1 C3435T polymorphisms and P-gp function in leukemic blasts (Jamroziak et al, 2005(Jamroziak et al, , 2006Hur et al, 2008) or responses and long-term outcomes among patients with AML (Jamroziak et al, 2005;Hur et al, 2008). In addition, the C/C genotype of C3435T was not associated with prognoses in a study of 143 Indian patients with AML (Rao et al, 2010).…”
Section: Mdr In Acute Myeloid Leukemia and Other Acutementioning
confidence: 92%
“…The role of ABCB1 variants in patients with other types of leukaemia remains unclear, as well. For acute myeloid leukaemia [131][132][133] and multiple myeloma [134], studies have failed to show meaningful significant effects.…”
Section: Imatinibmentioning
confidence: 99%
“…In a Korean study on acute lymphoblastic leukemia (ALL), however, there was lack of association of clinical endpoints such as complete remission rates, or relapsefree and event-free survival rates to ABCB1 variants (Hur et al, 2008). Only rare ABCB1 haplotypes of 2677G>T/A and 3435C>T differed in a large Hungarian ALL study, but overall, the genotype distribution was not statistically different (Semsei et al, 2008).…”
Section: Leukemiamentioning
confidence: 97%
“…In an Sf9 insect cell expression system, the three different amino acids A893S/T exhibited altered transport properties. 893T had a higher V max (Jeong et al, 2007), c (Hoffmeyer et al, 2000), d (Yang et al, 2008), e (Cascorbi et al, 2001); f (Crouthamel et al, 2006), g (Dulucq et al, 2008), h (Schaefer et al, 2006); i (Tanabe et al, 2001), j (Kim et al, 2001), k (Seedhouse et al, 2007), l (Hitzl et al, 2001), m (Siegmund et al, 2002), n (Kimchi-Sarfaty et al, 2002), o (van der Holt et al, 2006;Hur et al, 2008;Semsei et al, 2008); p (Sakaeda et al, 2001a), q (Kishi et al, 2004), r (Buda et al, 2007), s (Kafka et al, 2003), t Petrova et al, 2008), u (Lotsch et al, 2009), v …”
Section: Abcb1 Genetic Polymorphismsmentioning
confidence: 99%