C50 for Propofol-Remifentanil Target-Controlled Infusion and Bispectral Index at Loss of Consciousness and Response to Painful Stimulus in Chinese Patients: A Multicenter Clinical Trial

Abstract

The predicted blood and effect-site concentrations of propofol and BIS values at LOC were lower than those in previously published studies of Caucasian populations.

Asleep-awake-asleep regimen for epilepsy surgery: a prospective study of target-controlled infusion versus manually controlled infusion technique

“…There is evidence that the pharmacokinetic set developed in a European population for TCI dose not apply to Chinese patients, and predicted plasma and effect-site concentration of propofol and BIS value at LOC (loss of consciousness) in Chinese patients were lower than those in previously published studies of white population [11]. Actually, no data were provided regarding how much plasma concentration (Cp) of propofol and remifentanil for Chinese patients to induce LOC at this surgery.…”

“…Therefore, the discussion based on the total amount will be misleading. In addition, medication dose has a close relation to the difference of human race, and variability in drug responses could result from both genetic and environmental factors [27]. The impact of racial and genetic differences in the population studied was not accounted for in this study.…”

Geographic differences in the target-controlled infusion estimated concentration of propofol: bispectral index response curves

“…With a gentle tap on the shoulder every ten seconds, patients were asked whether they were still awake until a score of one was reached on the Observer's Assessment of Alertness and Sedation (OAA/S) Scale, i.e., no eyelash reflex and no response to verbal commands, which defined LOC. 5 The patients' lungs were ventilated via a facemask. Digitized BIS values, estimated C p , and predicted C e were collected continuously and stored on a laptop computer for the duration of the study.…”

“…4 There are studies wherein estimated concentrations of propofol have been examined at peak BIS effect using a TCI technique in Chinese populations. 5,6 Other studies using logistic regression sigmoid E max curves individually assessed the propofol estimated effective concentration (EC 50 ) at which 50% of Caucasian 7 or Chinese patients 8 did not respond to skin incision. We are not aware of previous studies directly comparing the performance of the widely used Diprifusor system, which incorporates the commonly used Marsh pharmacokinetic model, 9 between Chinese patients in China and Caucasian patients in Europe.…”

Population pharmacokinetics and pharmacodynamics in anesthesia, intensive care and pain medicine

“…Xu et al [32 ] evaluated the C 50 for propofol-remifentanil TCI and bispectral index (BIS) at loss of consciousness and response to noxious stimulus in Chinese patients and revealed that the predicted blood and effect-site concentrations at loss of consciousness were lower than those in previous publications involving Caucasian populations.…”