C57BL/6 life span study: age-related declines in muscle power production and contractile velocity

Graber, Ted G.; Kim, Jong Hee; Grange, Robert W.; McLoon, Linda K.; Thompson, LaDora V.

doi:10.1007/s11357-015-9773-1

Cited by 62 publications

(70 citation statements)

References 62 publications

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“…This finding is consistent with studies which report that power output is affected with age earlier than other performance outcomes such as static performance (i.e. isometric force) [20][21][22] . Rats at 3 months of age were in a late adolescent state of maturation as confirmed by 5% shorter tibia lengths and 24% lower body weights relative to those of 6 month old rats.…”

Section: Discussionsupporting

confidence: 92%

Age-dependent Muscle Adaptation after Chronic Stretch-shortening Contractions in Rats

Rader¹,

Layner²,

Triscuit³

et al. 2016

Aging and disease

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Age-related differences in contraction-induced adaptation have been well characterized especially for young and old rodent models but much less so at intermediate ages. Therefore, additional research is warranted to determine to what extent alterations in adaptation are due to maturation versus aging per se. The purpose of our study was to evaluate muscles of Fisher 344XBrown Norway rats of various ages following one month of exposure to stretch-shortening contractions (SSCs). With exposure, muscles mass increased by ~10% for 27 and 30 month old rats vs. ~20% for 3 and 6 month old rats (P < 0.05). For 3 month old rats, maximum isometric force and dynamic peak force increased by 22 ± 8% and 27 ± 10%, respectively (P < 0.05). For 6 month old rats, these forces were unaltered by exposure and positive work capacity diminished by 27 ± 2% (P = 0.006). By 30 months of age, age-related deficits in maximum isometric force, peak force, negative work, and positive work were apparent and SSC exposure was ineffective at counteracting such deficits. Recovery from fatigue was also tested and exposure-induced improvements in fatigue recovery were indicated for 6 month old rats and to a lesser extent for 3 month old rats whereas no such effect was observed for older rats. Alterations in fatigue recovery were accompanied by evidence of substantial type IIb to IIx fiber type shifting. These results highlight the exceptional adaptive capacity for strength at a young age, the inclination for adaptation in fatigue recovery at early adulthood, and diminished adaptation for muscle performance in general beginning at late adulthood. Such findings motivate careful investigation to determine appropriate SSC exposures at all stages of life.

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Section: Discussionsupporting

confidence: 92%

Age-dependent Muscle Adaptation after Chronic Stretch-shortening Contractions in Rats

Rader¹,

Layner²,

Triscuit³

et al. 2016

Aging and disease

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“…Conversely, in hamsters, aging decreased diaphragm maximal shortening velocity and peak power [89]. Ongoing studies by our group suggest that diaphragm bundles from mice in advanced stages of aging (30 mo old, <50% survival rate) also show decreases in maximal shortening velocity and peak power [90], which are consistent with those seen in limb muscles [91,92]. Thus, impairments in diaphragm isotonic contractile properties may have a delayed onset and be more relevant in very old age.…”

Section: Intrinsic Diaphragm Muscle Abnormalitiesmentioning

confidence: 62%

Diaphragm abnormalities in heart failure and aging: mechanisms and integration of cardiovascular and respiratory pathophysiology

Kelley

Ferreira

2016

Heart Fail Rev

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Inspiratory function is essential for alveolar ventilation and expulsive behaviors that promote airway clearance (e.g., coughing and sneezing). Current evidence demonstrates that inspiratory dysfunction occurs during healthy aging and is accentuated by chronic heart failure (CHF). This inspiratory dysfunction contributes to key aspects of CHF and aging cardiovascular and pulmonary pathophysiology including: i) impaired airway clearance and predisposition to pneumonia; ii) inability to sustain ventilation during physical activity; iii) shallow breathing pattern that limits alveolar ventilation and gas exchange; and iv) sympathetic activation that causes cardiac arrhythmias and tissue vasoconstriction. The diaphragm is the primary inspiratory muscle, hence, its neuromuscular integrity is a main determinant of the adequacy of inspiratory function. Mechanistic work within animal and cellular models has revealed specific factors that may be responsible for diaphragm neuromuscular abnormalities in CHF and aging. These include phrenic nerve and neuromuscular junction alterations as well as intrinsic myocyte abnormalities, such as changes in the quantity and quality of contractile proteins, accelerated fiber atrophy, and shifts in fiber type distribution. CHF, aging, or CHF in the presence of aging disturbs the dynamics of circulating factors (e.g., cytokines and angiotensin II) and cell signaling involving sphingolipids, reactive oxygen species, and proteolytic pathways, thus leading to the previously listed abnormalities. Exercise-based rehabilitation combined with pharmacological therapies targeting the pathways reviewed herein hold promise to treat diaphragm abnormalities and inspiratory muscle dysfunction in CHF and aging.

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“…This was particularly the case for comparison of myofiber CSA and absolute muscle mass, which suggested minimal differences between the young and aged mice. Other investigators have also observed that C57BL/6 mice show relatively mild changes in muscle at 24 months [ 32 , 33 ]. Interestingly, despite the lack of difference in absolute gastrocnemius muscle mass and findings of similar muscle fiber size, the aged mice demonstrated reduced muscle function on grip and during in situ twitch force testing.…”

Section: Discussionmentioning

confidence: 93%

Electrical impedance myography detects age-related muscle change in mice

Arnold

Taylor

et al. 2017

PLoS ONE

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Loss of muscle mass and strength represents one of the most significant contributors to impaired function in older adults. Convenient and non-invasive biomarkers are needed that can readily identify and track age-related muscle change. Previous data has suggested electrical impedance myography (EIM) has the potential to serve in this capacity. In this study we investigated how changes in EIM compared with other standard measures of muscle structure and function in aged compared with young mice. A total of 19 male mice aged approximately 25 months and 19 male mice aged 3 months underwent surface multifrequency EIM of the right gastrocnemius muscle using standard methods. Fore and hind limb grip strength, sciatic compound muscle action potential amplitude, and in-situ force of the gastrocnemius were also measured; after sacrifice, gastrocnemius myofiber size was assessed using standard histology. Spearman correlation coefficients were calculated to investigate the association between EIM and muscle characteristics. EIM in aged animals demonstrated significantly lower 50 kHz impedance phase (p<0.001) and reactance (p<0.01) values as well as reduced multifrequency parameters. In contrast, absolute gastrocnemius muscle mass was no different between young and aged mice (p = 0.58) but was reduced in aged mice after normalization to body mass (p<0.001). Median myofiber size in the aged mice was not different from that of young mice (p = 0.72). Aged mice showed reduced muscle function on the basis of normalized fore limb (p<0.001) and normalized hind limb (p<0.001) grip strength, as well as normalized gastrocnemius twitch (p<0.001) and normalized maximal isometric force (p<0.001). Sciatic compound muscle action potential amplitude was reduced in aged mice (p<0.05). EIM parameters showed good correlation with reduced standard physiological and electrophysiological measures of muscle health. Our study suggests that EIM is sensitive to aged-related muscle change and may represent a convenient and valuable method of quantifying loss of muscle health.

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C57BL/6 life span study: age-related declines in muscle power production and contractile velocity

Cited by 62 publications

References 62 publications

Age-dependent Muscle Adaptation after Chronic Stretch-shortening Contractions in Rats

Age-dependent Muscle Adaptation after Chronic Stretch-shortening Contractions in Rats

Diaphragm abnormalities in heart failure and aging: mechanisms and integration of cardiovascular and respiratory pathophysiology

Electrical impedance myography detects age-related muscle change in mice

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