C60 Fullerene Effect on the Dynamics of Fatigue Processes in Rat Soleus Muscle After Ischemia-Reperfusion

Nozdrenko, D. M.

doi:10.15407/biotech7.03.043

Cited by 5 publications

(4 citation statements)

References 4 publications

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“…Experiments were performed on 60 male Wistar rats in the age of 3 months, having weight of 170±5 g. Administration of C 60 FAS at a dose of 1 mg/kg [19] was carried out in two ways: intravenously (20 animals per group) and intramuscularly (20 animals per group) 2 hours before the beginning of each experiment. The control group (not received C 60 FAS) also contained 20 animals.…”

Section: Methodsmentioning

confidence: 99%

Impact of C[sub]60[/sub] fullerene on the dynamics of force-speed changes in soleus muscle of rat at ischemia-reperfusion injury

Nozdrenko¹,

Bogutska²,

Prylutskyy³

et al. 2015

Fiziol Zh

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The effect of C 60 fullerene nanoparticles (30-90 nm) on dynamics of force response development to stimulated soleus muscle of rat with ischemic pathology, existing in muscle during the first 5 hours and first 5 days after 2 hours of ischemia and further reperfusion, was investigated using the tensometric method. It was found that intravenous and intramuscular administration of С 60 fullerene with a single dose of 1 mg/kg exert different therapeutic effects dependent on the investigated macroparameters of muscle contraction. The intravenous drug administration was shown to be the most optimal for correction of the velocity macroparameters of contraction due to muscle tissue ischemic damage. In contrast, the intramuscular administration displays protective action with respect to motions associated with generation of maximal force response or continuous contractions elevating the level of muscle fatigue. Hence, С 60 fullerene, being a strong antioxidant, may be considered as a promising agent for effective therapy of pathological states of the muscle system caused by pathological action of free radical processes.

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Section: Methodsmentioning

confidence: 99%

Impact of C[sub]60[/sub] fullerene on the dynamics of force-speed changes in soleus muscle of rat at ischemia-reperfusion injury

Nozdrenko¹,

Bogutska²,

Prylutskyy³

et al. 2015

Fiziol Zh

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“…Nevertheless, the dynamics of this process remains largely unstudied . The onset of the equilibrium stable state of contraction under the effect of biologically active substances may vary within wide margins depending not only on the concentrations of the reagents used [7][8][9], but also on duration of the experiment [10,11]. This fact complicates the interpretation of the obtained experimental data and may result in severe errors in research planning.…”

mentioning

confidence: 99%

Aluminum chloride effect on Ca(2+),Mg(2+)-ATPase activity and dynamic parameters of skeletal muscle contraction

Nozdrenko¹,

Абрамчук²,

Soroca³

et al. 2015

Ukr.Biochem.J.

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We studied enzymatic activity and measured strain-gauge contraction properties of the frog rana temporaria m. tibialis anterior muscle fascicles during the action of aluminum chloride solution. It was shown that Alcl 3 solutions did not affect the dynamic properties of skeletal muscle preparation in concentrations less than 10-4 M. Increasing the concentration of Alcl 3 to 10-2 M induce complete inhibition of muscle contraction. A linear correlation between decrease in ca 2+ ,Mg 2+-ATPase activity of sarcoplasmic reticulum and the investigated concentrations range of aluminum chloride was observed. The reduction in the dynamic contraction performance and the decrease ca 2+ ,Mg 2+-ATPase activity of the sarcoplasmic reticulum under the effect of the investigated Alcl 3 solution were minimal in pre-tetanus period of contraction. k e y w o r d s: aluminum chloride, muscle contraction, ca 2+ ,Mg 2+-ATPase activity, muscle contractile force, length of muscle fibers.

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“…За нормальних умов її зміни у ди-наміці скорочення muscle soleus виявляються лише після 5-6 год стимуляції [73]. За умов ішемізації вже після 30-40 хв muscle soleus не спроможний відповідати генерацією сили на сигнал стимуляції [74]. Лінійне зниження силової відповіді ішемізованого м'яза прояв-лялось упродовж усього часу експерименту.…”

unclassified

“…Захисна дія препарату (порівняно зі змінами у рівнях генерації сили між початком і кінцем стимуляційних пулів) становила 15% в перші 5 год після ішемізації і зростала до 90% за 5-ту добу експерименту. У цьому разі його внутрішньовенне введення було найбільш оптимальним -92%-й захисний ефект при 63%-му за внутрішньом'язового введення [74].…”

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Prospects of C60 Fullerene Application as a Mean of Prevention and Correction of Ischemic-Reperfusion Injury in the Skeletal Muscle Tissue

Zay¹,

Zavodovskyi²,

Bogutska³

et al. 2016

Fiziol Zh

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C60 Fullerene Effect on the Dynamics of Fatigue Processes in Rat Soleus Muscle After Ischemia-Reperfusion

Cited by 5 publications

References 4 publications

Impact of C[sub]60[/sub] fullerene on the dynamics of force-speed changes in soleus muscle of rat at ischemia-reperfusion injury

Impact of C[sub]60[/sub] fullerene on the dynamics of force-speed changes in soleus muscle of rat at ischemia-reperfusion injury

Aluminum chloride effect on Ca(2+),Mg(2+)-ATPase activity and dynamic parameters of skeletal muscle contraction

Prospects of C60 Fullerene Application as a Mean of Prevention and Correction of Ischemic-Reperfusion Injury in the Skeletal Muscle Tissue

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