C825T polymorphism of the G-protein β3 subunit gene and atrial fibrillation: Association of the TT genotype with a reduced risk for atrial fibrillation

Schreieck, Jüergen; Dostal, Stefan; Beckerath, Nicolas von; Wacker, A.; Flory, Michelle; Weyerbrock, Sonja; Koch, Werner; Schömig, Albert; Schmitt, Claus

doi:10.1016/j.ahj.2004.03.024

Cited by 61 publications

(34 citation statements)

References 29 publications

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“…O paciente em questão, entretanto, é jovem e não tem história prévia de cardiopatia. Assim, supomos que o aparecimento de insuficiência cardíaca de baixo débito deva ter relação com o tempo sem tratamento (mais de um ano) e com a gravidade do hipertiroidismo (T4 livre de 15 ng/dl), porém não sendo esses os únicos mecanismos responsáveis pelas alterações nas proteínas contráteis e cardiomiopatia, principalmente em função de estudos sugerindo fatores genéticos relacionados ao surgimento de FA e eventualmente disfunção cardíaca (16).…”

Section: Discussionunclassified

Cardiomiopatia dilatada reversível relacionada a hipertireoidismo

Wildemberg

Sousa

Fonseca

et al. 2007

Arq Bras Endocrinol Metab

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RESUMOA insuficiência cardíaca é uma das complicações mais conhecidas do hipertireoidismo, sendo mais comumente de alto débito, mas alguns pacientes evoluem com miocardiopatia dilatada e baixa fração de ejeção. Apresentamos paciente de 35 anos, sexo masculino, com hipertireoidismo, fibrilação atrial (FA) e insuficiência cardíaca grave com disfunção sistólica e fração de ejeção de 43%. Após o tratamento definitivo do hipertireoidismo com radioiodo, houve reversão da insuficiência cardíaca, com melhora clínica e ecocardiográfica, incluindo normalização da fração de ejeção (69%). Vários são os casos descritos de reversão da insuficiência cardíaca com o tratamento do hipertiroidismo, porém na sua maioria de insuficiência cardíaca de alto débito. Os mecanismos pelo qual o hipertireoidismo pode levar à disfunção sistólica, assim como seu tratamento, são discutidos. Concluímos que o tratamento do hipertireoidismo pode recuperar a miocardiopatia tireotóxica, mesmo em casos mais graves com comprometimento da função sistólica. Heart failure is one of the most known complications of hyperthyroidism, more commonly high-output heart failure, but some patients may develop dilated cardiomyopathy with low ejection fraction. We report a 35-year-old man, with hyperthyroidism, atrial fibrillation, and severe heart failure with 43% of ejection fraction. After the definitive treatment of the hyperthyroidism with radioiodine, heart failure was reverted, with symptomatic improvement and echocardiographic normalization including a normal ejection fraction (69%). There are several cases of reversion of heart failure due to hyperthyroidism treatment, but most of them with a high-output heart failure. Mechanisms by which hyperthyroidism can lead to heart failure and its treatment are discussed. We conclude that treatment of hyperthyroidism may reverse this thyroid related heart failure, even in severe cases with systolic dysfunction.

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Section: Discussionunclassified

Cardiomiopatia dilatada reversível relacionada a hipertireoidismo

Wildemberg

Sousa

Fonseca

et al. 2007

Arq Bras Endocrinol Metab

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“…Fatini et al (2006) found that in non-valvular Caucasian AF patients the 38G allele of the minK gene is associated with AF. Schreieck et al (2004) reported that the C825T polymorphism is associated with sporadic AF, while patients with the TT genotype show a higher I K1 current density. This result also suggests that changes in the ion channel inward rectifying function are associated with familiar and sporadic AF (Schreieck et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

“…Schreieck et al (2004) reported that the C825T polymorphism is associated with sporadic AF, while patients with the TT genotype show a higher I K1 current density. This result also suggests that changes in the ion channel inward rectifying function are associated with familiar and sporadic AF (Schreieck et al, 2004). Ackerman et al (2003) found two mutations in the Asian population, namely G38S (112G>A, 16.4% of heterozygote frequency) and D85N (253G>A, 0.7% of heterozygote frequency).…”

Section: Discussionmentioning

confidence: 99%

Correlation analysis between the delayed rectifier potassium channel KCNE1 (G38S) polymorphism and atrial fibrillation among the senior Uygur population in Xinjiang

Wugeti¹,

Yujun²,

Shi³

et al. 2015

Genet. Mol. Res.

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“…40,[46][47][48][49][50][51][52][53][54][55][56][57][58] Candidate gene studies focus on specific genes that are selected based on a priori knowledge of their function, and compare the frequency of the variants between cohorts of individuals with and without disease. 59 To date, a number of candidate-gene association studies have identified common variants that are more prevalent in AF populations compared with control populations.…”

Section: Common Genetic Variants and Atrial Fibrillation In The Genermentioning

confidence: 99%

“…59 To date, a number of candidate-gene association studies have identified common variants that are more prevalent in AF populations compared with control populations. 40,[46][47][48][49][50][51][52][53][54][55][56][57][58] Often, the candidate genes have been selected based on results of studies in familial AF. As summarised in Table 2, a The recent advent of GWAS has led to significant progress in our understanding of the genetic basis of AF.…”

Section: Common Genetic Variants and Atrial Fibrillation In The Genermentioning

confidence: 99%

Genetic Discoveries in Atrial Fibrillation and Implications for Clinical Practice

Mahida

2014

Arrhythmia &Amp; Electrophysiology Review

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Linkage analysis and candidate-gene sequencing have identified multiple mutations in monogenic AF families and isolated AF cases. 2-31Linkage analysis involves performing genotyping of markers distributed AbstractAtrial fibrillation (AF) is an arrhythmia with a genetic basis. Over the past decade, rapid advances in genotyping technology have revolutionised research regarding the genetic basis of AF. While AF genetics research was previously largely restricted to familial forms of AF, recent studies have begun to characterise the genetic architecture underlying the form of AF encountered in everyday clinical practice. These discoveries could have a significant impact on the management of AF. However, much work remains before genetic findings can be translated to clinical practice. This review summarises results of studies in AF genetics to date and discusses the potential implications of these findings in clinical practice. KeywordsAtrial fibrillation, genetics, familial AF, linkage analysis, candidate gene association studies, genome-wide association studies, risk stratification Disclosure: The author has no conflicts of interest to declare.

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C825T polymorphism of the G-protein β3 subunit gene and atrial fibrillation: Association of the TT genotype with a reduced risk for atrial fibrillation

Cited by 61 publications

References 29 publications

Cardiomiopatia dilatada reversível relacionada a hipertireoidismo

Cardiomiopatia dilatada reversível relacionada a hipertireoidismo

Correlation analysis between the delayed rectifier potassium channel KCNE1 (G38S) polymorphism and atrial fibrillation among the senior Uygur population in Xinjiang

Genetic Discoveries in Atrial Fibrillation and Implications for Clinical Practice

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