C910 chemical compound inhibits the traffiking of several bacterial AB toxins with cross-protection against influenza virus

Wu, Yu; Mahtal, Nassim; Paillares, Elea; Swistak, Léa; Sagadiev, Sara; Acharya, Mridu; Demeret, Caroline; Werf, Sylvie van der; Guivel‐Benhassine, Florence; Petracchini, Serena; Mettouchi, Amel; Caramelle, Lucie; Couvineau, Pierre; Thaï, Robert; Barbe, Peggy; Keck, Mathilde; Brodin, Priscille; Machelart, Arnaud; Sencio, Valentin; Trottein, François; Sachse, Martin; Chicanne, Gaëtan; Payrastre, Bernard; Ville, Florian; Kreis, Victor; Popoff, Michel‐Robert; Johannes, Ludger; Cintrat, Jean‐Christophe; Barbier, Julien; Gillet, Daniel; Lemichez, Emmanuel

doi:10.1016/j.isci.2022.104537

iScience

2022

DOI: 10.1016/j.isci.2022.104537

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C910 chemical compound inhibits the traffiking of several bacterial AB toxins with cross-protection against influenza virus

Yu Wu

Nassim Mahtal

Elea Paillares

et al.

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Endolysosomal channel TMEM175 mediates antitoxin activity of DABMA

Wu,

Huang,

Zhang

et al. 2024

The FEBS Journal

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DABMA is a chemical molecule optimized from the parent compound ABMA and exhibits broad‐spectrum antipathogenic activity by modulating the host's endolysosomal and autophagic pathways. Both DABMA and ABMA inhibit severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in a cellular assay, which further expands their anti‐pathogen spectrum in vitro. However, their precise mechanism of action has not yet been resolved. TMEM175 is a newly characterized endolysosomal channel which plays an essential role in the homeostasis of endosomes and lysosomes as well as organelle fusion. Here, we show that DABMA increases the endosomal TMEM175 current through organelle patch clamping with an EC50 of 17.9 μm. Depletion of TMEM175 protein significantly decreases the antitoxin activity of DABMA and affects its action on acidic‐ and Rab7‐positive endosomes as well as on endolysosomal trafficking. Thus, TMEM175 is necessary for DABMA's activity and may represent a druggable target for the development of anti‐infective drugs. Moreover, DABMA, as an activator of the TMEM175 channel, may be useful for the in‐depth characterization of the physiological and pathological roles of this endolysosomal channel.

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Endolysosomal channel TMEM175 mediates antitoxin activity of DABMA

Wu,

Huang,

Zhang

et al. 2024

The FEBS Journal

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show abstract

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C910 chemical compound inhibits the traffiking of several bacterial AB toxins with cross-protection against influenza virus

Cited by 1 publication

References 90 publications

Endolysosomal channel TMEM175 mediates antitoxin activity of DABMA

Endolysosomal channel TMEM175 mediates antitoxin activity of DABMA

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